ID:MAP2_HUMAN DESCRIPTION: RecName: Full=Microtubule-associated protein 2; Short=MAP-2; FUNCTION: The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. INTERACTION: Q13951:CBFB; NbExp=2; IntAct=EBI-2682460, EBI-718750; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (Probable). PTM: Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). MAP2A/c is phosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR. Isoform MAP2c is phosphorylated by FYN at Tyr-67. SIMILARITY: Contains 3 Tau/MAP repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00418 - Tau and MAP protein, tubulin-binding repeat PF08377 - MAP2/Tau projection domain
ModBase Predicted Comparative 3D Structure on P11137
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000226 microtubule cytoskeleton organization GO:0001578 microtubule bundle formation GO:0007409 axonogenesis GO:0016358 dendrite development GO:0021954 central nervous system neuron development GO:0030010 establishment of cell polarity GO:0030517 negative regulation of axon extension GO:0031113 regulation of microtubule polymerization GO:0031115 negative regulation of microtubule polymerization GO:0031175 neuron projection development GO:0048813 dendrite morphogenesis GO:0050770 regulation of axonogenesis GO:0071310 cellular response to organic substance GO:1901953 positive regulation of anterograde dense core granule transport GO:1902513 regulation of organelle transport along microtubule GO:1903744 positive regulation of anterograde synaptic vesicle transport GO:1903827 regulation of cellular protein localization GO:1904527 negative regulation of microtubule binding GO:2000575 negative regulation of microtubule motor activity
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
