Human Gene MAOA (ENST00000338702.4_4) from GENCODE V47lift37

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Description: monoamine oxidase A, transcript variant 1 (from RefSeq NM_000240.4)
Gencode Transcript: ENST00000338702.4_4
Gencode Gene: ENSG00000189221.11_6
Transcript (Including UTRs)
Position: hg19 chrX:43,515,547-43,606,064 Size: 90,518 Total Exon Count: 15 Strand: +
Coding Region
Position: hg19 chrX:43,515,590-43,603,760 Size: 88,171 Coding Exon Count: 15

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chrX:43,515,547-43,606,064)			mRNA (may differ from genome)		Protein (527 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Human Cortex Gene Expression	Malacards	MGI	OMIM	PubMed
UniProtKB	Wikipedia	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: MAOA Diseases sorted by gene-association score: brunner syndrome* (1121), maoa-related behavior disorders* (100), antisocial personality disorder (35), social phobia (33), conduct disorder (31), endogenous depression (29), personality disorder (20), borderline personality disorder (20), paranoid schizophrenia (17), phobic disorder (17), atypical depressive disorder (17), dysthymic disorder (16), serotonin syndrome (14), anxiety disorder (14), mood disorder (14), norrie disease (13), agoraphobia (13), chronic fatigue syndrome (11), generalized anxiety disorder (11), oppositional defiant disorder (10), hepatic encephalopathy (10), panic disorder (10), postpartum depression (10), phobia, specific (9), avoidant personality disorder (9), pathological gambling (9), dependent personality disorder (8), obsessive-compulsive disorder (8), post-traumatic stress disorder (8), exhibitionism (8), sudden infant death syndrome (8), substance abuse (8), retinitis pigmentosa-50 (8), bulimia nervosa (7), alcohol dependence (7), attention deficit-hyperactivity disorder (7), substance dependence (7), paraphilia disorder (7), mental depression (6), migraine with or without aura 1 (6), dystonia-1, torsion (6), kleptomania (5), early-onset schizophrenia (5), nicotine dependence, protection against (5), mediastinal malignant lymphoma (5), mediastinal gray zone lymphoma (5), pure autonomic failure (3), parkinson disease, late-onset (3), autism spectrum disorder (2), schizophrenia (2), disease of mental health (2) * = Manually curated disease association

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D003010 Clorgyline D012701 Serotonin D004958 Estradiol D009638 Norepinephrine C019132 3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole C019133 3-amino-1-methyl-5H-pyrido(4,3-b)indole D000082 Acetaminophen D001564 Benzo(a)pyrene D003907 Dexamethasone D004006 Dichlorvos more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 111.16 RPKM in Small Intestine - Terminal Ileum Total median expression: 1572.91 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-8.10	43	-0.188	Picture	PostScript	Text
3' UTR	-613.20	2304	-0.266	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR002937 - Amino_oxidase
IPR001613 - Flavin_amine_oxidase

Pfam Domains:
PF00070 - Pyridine nucleotide-disulphide oxidoreductase
PF00890 - FAD binding domain
PF01266 - FAD dependent oxidoreductase
PF01494 - FAD binding domain
PF01593 - Flavin containing amine oxidoreductase
PF13450 - NAD(P)-binding Rossmann-like domain

SCOP Domains:
51735 - NAD(P)-binding Rossmann-fold domains
51905 - FAD/NAD(P)-binding domain
52440 - PreATP-grasp domain
51971 - Nucleotide-binding domain
51984 - MurCD N-terminal domain
54373 - FAD-linked reductases, C-terminal domain

ModBase Predicted Comparative 3D Structure on Q53YE7


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0008131 primary amine oxidase activity GO:0016491 oxidoreductase activity Biological Process: GO:0042420 dopamine catabolic process GO:0055114 oxidation-reduction process Cellular Component: GO:0005739 mitochondrion

Descriptions from all associated GenBank mRNAs


	BC044787 - Homo sapiens monoamine oxidase A, mRNA (cDNA clone MGC:42558 IMAGE:4824582), complete cds. AK223499 - Homo sapiens mRNA for monoamine oxidase A variant, clone: FCC121A07. M68840 - Human monoamine oxidase A (MAOA) mRNA, complete cds. AK293926 - Homo sapiens cDNA FLJ61220 complete cds, highly similar to Amine oxidase (flavin-containing) A (EC 1.4.3.4). AK291769 - Homo sapiens cDNA FLJ76052 complete cds, highly similar to Homo sapiens monoamine oxidase A (MAOA), nuclear gene encoding mitochondrial protein, mRNA. BC008064 - Homo sapiens monoamine oxidase A, mRNA (cDNA clone MGC:2288 IMAGE:2990003), complete cds. M69226 - Human monoamine oxidase (MAOA) mRNA, complete cds. CU675911 - Synthetic construct Homo sapiens gateway clone IMAGE:100020324 5' read MAOA mRNA. KJ897163 - Synthetic construct Homo sapiens clone ccsbBroadEn_06557 MAOA gene, encodes complete protein. DQ890676 - Synthetic construct clone IMAGE:100003306; FLH165001.01X; RZPDo839E07158D monoamine oxidase A (MAOA) gene, encodes complete protein. DQ893857 - Synthetic construct Homo sapiens clone IMAGE:100008317; FLH164997.01L; RZPDo839E07157D monoamine oxidase A (MAOA) gene, encodes complete protein. BT006651 - Homo sapiens monoamine oxidase A mRNA, complete cds. AK123241 - Homo sapiens cDNA FLJ41247 fis, clone BRAMY2032777. X17192 - Human mRNA for placental monoamine oxidase A (MAO A) (EC 1.4.3.4).

Biochemical and Signaling Pathways


	BioCyc Knowledge Library PWY-0 - putrescine degradation III PWY-6313 - serotonin degradation PWY-6342 - noradrenaline and adrenaline degradation PWY-6399 - melatonin degradation II PWY-6402 - superpathway of melatonin degradation PWY66-401 - superpathway of L-tryptophan utilization PWY6666-2 - dopamine degradation

Other Names for This Gene


	Alternate Gene Symbols: ENST00000338702.1, ENST00000338702.2, ENST00000338702.3, hCG_16826 , MAOA , NM_000240, Q53YE7, Q53YE7_HUMAN, uc317vcs.1, uc317vcs.2 UCSC ID: ENST00000338702.4_4 RefSeq Accession: NM_000240.4 Protein: Q53YE7

Gene Model Information


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Methods, Credits, and Use Restrictions


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