ID:MACC1_HUMAN DESCRIPTION: RecName: Full=Metastasis-associated in colon cancer protein 1; AltName: Full=SH3 domain-containing protein 7a5; FUNCTION: Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo. SUBUNIT: Interacts with FASLG. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Mainly found in the cytoplasm in non-metastasizing tumors. TISSUE SPECIFICITY: Preferentially expressed in metastasizing tumors. SIMILARITY: Contains 1 SH3 domain. SEQUENCE CAUTION: Sequence=BAC87646.1; Type=Erroneous initiation; Sequence=EAW93719.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 47986 - DEATH domain 50044 - SH3-domain
ModBase Predicted Comparative 3D Structure on Q6ZN28
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0008083 growth factor activity
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0010469 regulation of receptor activity GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0051781 positive regulation of cell division
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
