Human Gene LZTS3 (ENST00000329152.7_7) from GENCODE V47lift37

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Description: leucine zipper tumor suppressor family member 3, transcript variant 6 (from RefSeq NM_001388191.1)
Gencode Transcript: ENST00000329152.7_7
Gencode Gene: ENSG00000088899.16_11
Transcript (Including UTRs)
Position: hg19 chr20:3,143,263-3,149,207 Size: 5,945 Total Exon Count: 3 Strand: -
Coding Region
Position: hg19 chr20:3,145,100-3,147,809 Size: 2,710 Coding Exon Count: 3

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr20:3,143,263-3,149,207)			mRNA (may differ from genome)		Protein (673 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	ExonPrimer	GeneCards	MGI
PubMed	UniProtKB	Wikipedia

Comments and Description Text from UniProtKB


	ID: PRIP1_HUMAN DESCRIPTION: RecName: Full=ProSAP-interacting protein 1; Short=ProSAPiP1; SUBUNIT: Interacts (via C-terminus) with SHANK3 (via PDZ domain). Interacts (via coiled coil) with SIPA1L1. Can form homooligomers (By similarity). SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Detected at synapses, postsynaptic density, synaptic spines and dendrites (By similarity). SIMILARITY: Belongs to the PROSAPIP1 family. SEQUENCE CAUTION: Sequence=BAA25478.2; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen D000643 Ammonium Chloride D002794 Choline D003042 Cocaine D005492 Folic Acid D008715 Methionine D018817 N-Methyl-3,4-methylenedioxyamphetamine D013749 Tetrachlorodibenzodioxin

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 127.58 RPKM in Brain - Cerebellum Total median expression: 893.11 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-659.00	1398	-0.471	Picture	PostScript	Text
3' UTR	-712.60	1837	-0.388	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR009638 - Fez1

Pfam Domains:
PF06818 - Fez1

ModBase Predicted Comparative 3D Structure on O60299


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Biological Process: GO:0061001 regulation of dendritic spine morphogenesis Cellular Component: GO:0005737 cytoplasm GO:0005856 cytoskeleton GO:0005886 plasma membrane GO:0014069 postsynaptic density GO:0016020 membrane GO:0030054 cell junction GO:0045202 synapse GO:0045211 postsynaptic membrane

Descriptions from all associated GenBank mRNAs


	LF205905 - JP 2014500723-A/13408: Polycomb-Associated Non-Coding RNAs. AB011124 - Homo sapiens mRNA for KIAA0552 protein, partial cds. BC038860 - Homo sapiens ProSAPiP1 protein, mRNA (cDNA clone MGC:33747 IMAGE:5260571), complete cds. DQ895655 - Synthetic construct Homo sapiens clone IMAGE:100010115; FLH186373.01L; RZPDo839D1161D ProSAPiP1 protein (ProSAPiP1) gene, encodes complete protein. AB383905 - Synthetic construct DNA, clone: pF1KSDA0552, Homo sapiens KIAA0552 gene for KIAA0552 protein, complete cds, without stop codon, in Flexi system. MA441482 - JP 2018138019-A/13408: Polycomb-Associated Non-Coding RNAs. LF349526 - JP 2014500723-A/157029: Polycomb-Associated Non-Coding RNAs. JD475148 - Sequence 456172 from Patent EP1572962. JD425700 - Sequence 406724 from Patent EP1572962. JD157437 - Sequence 138461 from Patent EP1572962. JD368132 - Sequence 349156 from Patent EP1572962. JD157436 - Sequence 138460 from Patent EP1572962. JD401185 - Sequence 382209 from Patent EP1572962. JD541542 - Sequence 522566 from Patent EP1572962. JD335929 - Sequence 316953 from Patent EP1572962. JD096005 - Sequence 77029 from Patent EP1572962. JD165558 - Sequence 146582 from Patent EP1572962. JD067752 - Sequence 48776 from Patent EP1572962. JD134300 - Sequence 115324 from Patent EP1572962. JD392552 - Sequence 373576 from Patent EP1572962. JD085039 - Sequence 66063 from Patent EP1572962. JD111204 - Sequence 92228 from Patent EP1572962. JD067587 - Sequence 48611 from Patent EP1572962. JD123703 - Sequence 104727 from Patent EP1572962. JD387620 - Sequence 368644 from Patent EP1572962. JD554921 - Sequence 535945 from Patent EP1572962. JD367100 - Sequence 348124 from Patent EP1572962. DQ599014 - Homo sapiens piRNA piR-37080, complete sequence. JD199110 - Sequence 180134 from Patent EP1572962. JD193614 - Sequence 174638 from Patent EP1572962. JD370000 - Sequence 351024 from Patent EP1572962. JD424851 - Sequence 405875 from Patent EP1572962. JD233475 - Sequence 214499 from Patent EP1572962. JD233450 - Sequence 214474 from Patent EP1572962. JD560033 - Sequence 541057 from Patent EP1572962. JD261963 - Sequence 242987 from Patent EP1572962. JD240141 - Sequence 221165 from Patent EP1572962. JD561059 - Sequence 542083 from Patent EP1572962. JD130269 - Sequence 111293 from Patent EP1572962. JD520964 - Sequence 501988 from Patent EP1572962. JD259260 - Sequence 240284 from Patent EP1572962. JD393769 - Sequence 374793 from Patent EP1572962. LF349528 - JP 2014500723-A/157031: Polycomb-Associated Non-Coding RNAs. JD158154 - Sequence 139178 from Patent EP1572962. JD230383 - Sequence 211407 from Patent EP1572962. JD103385 - Sequence 84409 from Patent EP1572962. JD332996 - Sequence 314020 from Patent EP1572962. JD205291 - Sequence 186315 from Patent EP1572962. JD394356 - Sequence 375380 from Patent EP1572962. JD038929 - Sequence 19953 from Patent EP1572962. JD302324 - Sequence 283348 from Patent EP1572962. JD149150 - Sequence 130174 from Patent EP1572962. JD507180 - Sequence 488204 from Patent EP1572962. JD390540 - Sequence 371564 from Patent EP1572962. JD251531 - Sequence 232555 from Patent EP1572962. JD226528 - Sequence 207552 from Patent EP1572962. JD232490 - Sequence 213514 from Patent EP1572962. JD109283 - Sequence 90307 from Patent EP1572962. JD044854 - Sequence 25878 from Patent EP1572962. MA585103 - JP 2018138019-A/157029: Polycomb-Associated Non-Coding RNAs. MA585105 - JP 2018138019-A/157031: Polycomb-Associated Non-Coding RNAs. LF349529 - JP 2014500723-A/157032: Polycomb-Associated Non-Coding RNAs. LF349530 - JP 2014500723-A/157033: Polycomb-Associated Non-Coding RNAs. JD321401 - Sequence 302425 from Patent EP1572962. JD536335 - Sequence 517359 from Patent EP1572962. JD113955 - Sequence 94979 from Patent EP1572962. JD274158 - Sequence 255182 from Patent EP1572962. JD560346 - Sequence 541370 from Patent EP1572962. JD389232 - Sequence 370256 from Patent EP1572962. JD318079 - Sequence 299103 from Patent EP1572962. JD199347 - Sequence 180371 from Patent EP1572962. JD081701 - Sequence 62725 from Patent EP1572962. JD169470 - Sequence 150494 from Patent EP1572962. JD350338 - Sequence 331362 from Patent EP1572962. JD120233 - Sequence 101257 from Patent EP1572962. JD525501 - Sequence 506525 from Patent EP1572962. JD515485 - Sequence 496509 from Patent EP1572962. JD259258 - Sequence 240282 from Patent EP1572962. JD485720 - Sequence 466744 from Patent EP1572962. JD486636 - Sequence 467660 from Patent EP1572962. JD462115 - Sequence 443139 from Patent EP1572962. JD044673 - Sequence 25697 from Patent EP1572962. JD060124 - Sequence 41148 from Patent EP1572962. JD227709 - Sequence 208733 from Patent EP1572962. JD142259 - Sequence 123283 from Patent EP1572962. JD433857 - Sequence 414881 from Patent EP1572962. JD076317 - Sequence 57341 from Patent EP1572962. JD411506 - Sequence 392530 from Patent EP1572962. JD232601 - Sequence 213625 from Patent EP1572962. JD107312 - Sequence 88336 from Patent EP1572962. JD457602 - Sequence 438626 from Patent EP1572962. JD191350 - Sequence 172374 from Patent EP1572962. JD538422 - Sequence 519446 from Patent EP1572962. JD423303 - Sequence 404327 from Patent EP1572962. LF349532 - JP 2014500723-A/157035: Polycomb-Associated Non-Coding RNAs. JD520629 - Sequence 501653 from Patent EP1572962. LF349533 - JP 2014500723-A/157036: Polycomb-Associated Non-Coding RNAs. JD561635 - Sequence 542659 from Patent EP1572962. MA585106 - JP 2018138019-A/157032: Polycomb-Associated Non-Coding RNAs. MA585107 - JP 2018138019-A/157033: Polycomb-Associated Non-Coding RNAs. MA585109 - JP 2018138019-A/157035: Polycomb-Associated Non-Coding RNAs. MA585110 - JP 2018138019-A/157036: Polycomb-Associated Non-Coding RNAs.

Other Names for This Gene


	Alternate Gene Symbols: A2A2Q7, D3DVX6, ENST00000329152.1, ENST00000329152.2, ENST00000329152.3, ENST00000329152.4, ENST00000329152.5, ENST00000329152.6, KIAA0552 , LZTS3 , LZTS3_HUMAN, NM_001388191, O60299, PROSAPIP1 , Q8IXX8, uc317src.1, uc317src.2 UCSC ID: ENST00000329152.7_7 RefSeq Accession: NM_001388191.1 Protein: O60299 (aka PRIP1_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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