ID:LZTS2_HUMAN DESCRIPTION: RecName: Full=Leucine zipper putative tumor suppressor 2; Short=hLZTS2; AltName: Full=Protein LAPSER1; FUNCTION: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. SUBUNIT: Interacts with KATNB1. Also interacts with CTNNB1, gamma- tubulin and KIF23. SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Note=Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis. TISSUE SPECIFICITY: Highly expressed in prostate and testis, and at slightly lower levels in spleen, thymus, uterus, small intestine and colon. INDUCTION: By inhibition of NF-kappa-B signaling. SIMILARITY: Belongs to the LZTS2 family. SEQUENCE CAUTION: Sequence=BAB47442.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BRK4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
