Human Gene LUZP2 (ENST00000336930.11_9) from GENCODE V47lift37
  Description: leucine zipper protein 2, transcript variant 3 (from RefSeq NM_001252010.2)
Gencode Transcript: ENST00000336930.11_9
Gencode Gene: ENSG00000187398.12_14
Transcript (Including UTRs)
   Position: hg19 chr11:24,518,599-25,104,184 Size: 585,586 Total Exon Count: 12 Strand: +
Coding Region
   Position: hg19 chr11:24,518,790-25,100,204 Size: 581,415 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:24,518,599-25,104,184)mRNA (may differ from genome)Protein (346 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: LUZP2_HUMAN
DESCRIPTION: RecName: Full=Leucine zipper protein 2; Flags: Precursor;
SUBCELLULAR LOCATION: Secreted (Potential).
SEQUENCE CAUTION: Sequence=CAD90000.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: LUZP2
Diseases sorted by gene-association score: wagr syndrome (8), aniridia (8)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.02 RPKM in Brain - Hypothalamus
Total median expression: 35.77 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -73.90191-0.387 Picture PostScript Text
3' UTR -927.103980-0.233 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026718 - Luzp2

ModBase Predicted Comparative 3D Structure on Q86TE4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005576 extracellular region


-  Descriptions from all associated GenBank mRNAs
  KJ905079 - Synthetic construct Homo sapiens clone ccsbBroadEn_14473 LUZP2-like gene, encodes complete protein.
AK127695 - Homo sapiens cDNA FLJ45795 fis, clone NT2RI2010795.
AY164460 - Homo sapiens leucine-zipper motif 2-like protein mRNA, complete sequence.
AL832641 - Homo sapiens mRNA; cDNA DKFZp451K1618 (from clone DKFZp451K1618).
AY358386 - Homo sapiens clone DNA108806 KFSP2566 (UNQ2566) mRNA, complete cds.
BC132829 - Homo sapiens leucine zipper protein 2, mRNA (cDNA clone MGC:164460 IMAGE:40146851), complete cds.
BC144177 - Homo sapiens cDNA clone IMAGE:9052697.
AK309077 - Homo sapiens cDNA, FLJ99118.
BC151234 - Homo sapiens cDNA clone IMAGE:8860410, containing frame-shift errors.
HQ258382 - Synthetic construct Homo sapiens clone IMAGE:100072811 leucine zipper protein 2 (LUZP2) gene, encodes complete protein.
AK126974 - Homo sapiens cDNA FLJ45027 fis, clone BRAWH3017980.
JD065178 - Sequence 46202 from Patent EP1572962.
JD248976 - Sequence 230000 from Patent EP1572962.
JD439645 - Sequence 420669 from Patent EP1572962.
JD060382 - Sequence 41406 from Patent EP1572962.
JD506436 - Sequence 487460 from Patent EP1572962.
JD080998 - Sequence 62022 from Patent EP1572962.
X81895 - H.sapiens GENX-5624 mRNA, 3' UTR.
JD260521 - Sequence 241545 from Patent EP1572962.
JD284862 - Sequence 265886 from Patent EP1572962.
JD245675 - Sequence 226699 from Patent EP1572962.
JD434103 - Sequence 415127 from Patent EP1572962.
JD236250 - Sequence 217274 from Patent EP1572962.
JD120207 - Sequence 101231 from Patent EP1572962.
JD237961 - Sequence 218985 from Patent EP1572962.
JD037263 - Sequence 18287 from Patent EP1572962.
JD227324 - Sequence 208348 from Patent EP1572962.
JD137060 - Sequence 118084 from Patent EP1572962.
JD041042 - Sequence 22066 from Patent EP1572962.
JD250603 - Sequence 231627 from Patent EP1572962.
BC042863 - Homo sapiens leucine zipper protein 2, mRNA (cDNA clone IMAGE:5314528).
JD510076 - Sequence 491100 from Patent EP1572962.
JD276546 - Sequence 257570 from Patent EP1572962.
JD293317 - Sequence 274341 from Patent EP1572962.
JD262111 - Sequence 243135 from Patent EP1572962.
JD165266 - Sequence 146290 from Patent EP1572962.
JD560975 - Sequence 541999 from Patent EP1572962.
JD542957 - Sequence 523981 from Patent EP1572962.
JD213197 - Sequence 194221 from Patent EP1572962.
JD463161 - Sequence 444185 from Patent EP1572962.
JD252621 - Sequence 233645 from Patent EP1572962.
JD384798 - Sequence 365822 from Patent EP1572962.
JD520387 - Sequence 501411 from Patent EP1572962.
JD415247 - Sequence 396271 from Patent EP1572962.
JD345683 - Sequence 326707 from Patent EP1572962.
JD225368 - Sequence 206392 from Patent EP1572962.
JD072333 - Sequence 53357 from Patent EP1572962.
JD207675 - Sequence 188699 from Patent EP1572962.
JD429051 - Sequence 410075 from Patent EP1572962.
JD358927 - Sequence 339951 from Patent EP1572962.
JD320242 - Sequence 301266 from Patent EP1572962.
JD360281 - Sequence 341305 from Patent EP1572962.
JD283525 - Sequence 264549 from Patent EP1572962.
JD087320 - Sequence 68344 from Patent EP1572962.
JD348951 - Sequence 329975 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A2RUB8, E9PN53, ENST00000336930.1, ENST00000336930.10, ENST00000336930.2, ENST00000336930.3, ENST00000336930.4, ENST00000336930.5, ENST00000336930.6, ENST00000336930.7, ENST00000336930.8, ENST00000336930.9, LUZP2_HUMAN, NM_001252010, Q6UXE7, Q6ZS65, Q86TE4, uc317uqs.1, uc317uqs.2, UNQ2566/PRO6246
UCSC ID: ENST00000336930.11_9
RefSeq Accession: NM_001009909.4
Protein: Q86TE4 (aka LUZP2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.