Human Gene LUZP1 (ENST00000302291.9_10) from GENCODE V47lift37

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Description: Q86V48; P31947: SFN; NbExp=4; IntAct=EBI-350467, EBI-476295; Q86V48; P62258: YWHAE; NbExp=3; IntAct=EBI-350467, EBI-356498; (from UniProt Q86V48)
Gencode Transcript: ENST00000302291.9_10
Gencode Gene: ENSG00000169641.16_14
Transcript (Including UTRs)
Position: hg19 chr1:23,410,523-23,495,349 Size: 84,827 Total Exon Count: 4 Strand: -
Coding Region
Position: hg19 chr1:23,415,388-23,420,754 Size: 5,367 Coding Exon Count: 2

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:23,410,523-23,495,349)			mRNA (may differ from genome)		Protein (1076 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	ExonPrimer	GeneCards	HGNC
Malacards	MGI	PubMed	UniProtKB

Comments and Description Text from UniProtKB


	ID: LUZP1_HUMAN DESCRIPTION: RecName: Full=Leucine zipper protein 1; SUBCELLULAR LOCATION: Nucleus. Note=Also detected in soma and dendrites of neurons (By similarity). SEQUENCE CAUTION: Sequence=AAH33219.1; Type=Erroneous initiation; Sequence=CAI19705.1; Type=Erroneous gene model prediction;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: LUZP1 Diseases sorted by gene-association score: chromosome 1p36 deletion syndrome (6), left ventricular noncompaction (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen D003993 Dibutyl Phthalate D013749 Tetrachlorodibenzodioxin C023514 2,6-dinitrotoluene C009505 4,4'-diaminodiphenylmethane D000643 Ammonium Chloride D001564 Benzo(a)pyrene D002945 Cisplatin D014635 Valproic Acid C044887 beta-methylcholine more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 9.64 RPKM in Testis Total median expression: 247.91 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-112.20	316	-0.355	Picture	PostScript	Text
3' UTR	-1594.80	4865	-0.328	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR026734 - Luzp1

ModBase Predicted Comparative 3D Structure on Q86V48


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Biological Process: GO:0003281 ventricular septum development GO:0021503 neural fold bending GO:0060840 artery development Cellular Component: GO:0005634 nucleus GO:0016020 membrane GO:0070062 extracellular exosome

Descriptions from all associated GenBank mRNAs


	BC051733 - Homo sapiens leucine zipper protein 1, mRNA (cDNA clone MGC:51018 IMAGE:4838475), complete cds. BC016175 - Homo sapiens leucine zipper protein 1, mRNA (cDNA clone IMAGE:3922035), partial cds. AK093016 - Homo sapiens cDNA FLJ35697 fis, clone SPLEN2019793, highly similar to Rattus norvegicus putative transcription factor LUZP (Luzp) mRNA. AX747858 - Sequence 1383 from Patent EP1308459. BC002428 - Homo sapiens, Similar to KIAA1275 protein, clone IMAGE:3346688, mRNA. AL831896 - Homo sapiens mRNA; cDNA DKFZp547N028 (from clone DKFZp547N028). AK025345 - Homo sapiens cDNA: FLJ21692 fis, clone COL09588. AK000297 - Homo sapiens cDNA FLJ20290 fis, clone HEP04540. JD313717 - Sequence 294741 from Patent EP1572962. JD444485 - Sequence 425509 from Patent EP1572962. JD560187 - Sequence 541211 from Patent EP1572962. JD384126 - Sequence 365150 from Patent EP1572962. JD180710 - Sequence 161734 from Patent EP1572962. JD137313 - Sequence 118337 from Patent EP1572962. JD418159 - Sequence 399183 from Patent EP1572962. JD152837 - Sequence 133861 from Patent EP1572962. JD099356 - Sequence 80380 from Patent EP1572962. JD474793 - Sequence 455817 from Patent EP1572962. JD508333 - Sequence 489357 from Patent EP1572962. JD328580 - Sequence 309604 from Patent EP1572962. JD333717 - Sequence 314741 from Patent EP1572962. JD554603 - Sequence 535627 from Patent EP1572962. JD255348 - Sequence 236372 from Patent EP1572962. JD210747 - Sequence 191771 from Patent EP1572962. JD210746 - Sequence 191770 from Patent EP1572962. JD078167 - Sequence 59191 from Patent EP1572962. JD068784 - Sequence 49808 from Patent EP1572962. JD215839 - Sequence 196863 from Patent EP1572962. JD038833 - Sequence 19857 from Patent EP1572962. JD077500 - Sequence 58524 from Patent EP1572962. JD289313 - Sequence 270337 from Patent EP1572962. JD492798 - Sequence 473822 from Patent EP1572962. JD216218 - Sequence 197242 from Patent EP1572962. JD484543 - Sequence 465567 from Patent EP1572962. JD039130 - Sequence 20154 from Patent EP1572962. JD199781 - Sequence 180805 from Patent EP1572962. JD465676 - Sequence 446700 from Patent EP1572962. JD540740 - Sequence 521764 from Patent EP1572962. JD308565 - Sequence 289589 from Patent EP1572962. JD550975 - Sequence 531999 from Patent EP1572962. JD466203 - Sequence 447227 from Patent EP1572962. JD235713 - Sequence 216737 from Patent EP1572962. JD359669 - Sequence 340693 from Patent EP1572962. JD245502 - Sequence 226526 from Patent EP1572962. JD241717 - Sequence 222741 from Patent EP1572962. JD423410 - Sequence 404434 from Patent EP1572962. JD200615 - Sequence 181639 from Patent EP1572962. JD369972 - Sequence 350996 from Patent EP1572962. JD352857 - Sequence 333881 from Patent EP1572962. JD552024 - Sequence 533048 from Patent EP1572962. JD368702 - Sequence 349726 from Patent EP1572962. JD548810 - Sequence 529834 from Patent EP1572962. JD562971 - Sequence 543995 from Patent EP1572962. JD489708 - Sequence 470732 from Patent EP1572962. JD258119 - Sequence 239143 from Patent EP1572962. JD267650 - Sequence 248674 from Patent EP1572962. JD440306 - Sequence 421330 from Patent EP1572962. JD042761 - Sequence 23785 from Patent EP1572962. JD091600 - Sequence 72624 from Patent EP1572962. BC033219 - Homo sapiens leucine zipper protein 1, mRNA (cDNA clone IMAGE:5017908), complete cds. JD553894 - Sequence 534918 from Patent EP1572962. JD380793 - Sequence 361817 from Patent EP1572962. JD151301 - Sequence 132325 from Patent EP1572962. JD325024 - Sequence 306048 from Patent EP1572962. JD378548 - Sequence 359572 from Patent EP1572962. JD420294 - Sequence 401318 from Patent EP1572962. JD133859 - Sequence 114883 from Patent EP1572962. JD477252 - Sequence 458276 from Patent EP1572962. JD424167 - Sequence 405191 from Patent EP1572962. JD148185 - Sequence 129209 from Patent EP1572962. JD084995 - Sequence 66019 from Patent EP1572962. JD083727 - Sequence 64751 from Patent EP1572962. JD441831 - Sequence 422855 from Patent EP1572962. JD185940 - Sequence 166964 from Patent EP1572962. JD557046 - Sequence 538070 from Patent EP1572962. JD054530 - Sequence 35554 from Patent EP1572962. JD509835 - Sequence 490859 from Patent EP1572962. JD483243 - Sequence 464267 from Patent EP1572962. JD130830 - Sequence 111854 from Patent EP1572962. JD329970 - Sequence 310994 from Patent EP1572962. JD133107 - Sequence 114131 from Patent EP1572962. AK074153 - Homo sapiens mRNA for FLJ00226 protein. EU446984 - Synthetic construct Homo sapiens clone IMAGE:100070328; IMAGE:100012193; FLH258403.01L leucine zipper protein 1 (LUZP1) gene, encodes complete protein. JD287114 - Sequence 268138 from Patent EP1572962. JD357503 - Sequence 338527 from Patent EP1572962. JD205067 - Sequence 186091 from Patent EP1572962. JD456607 - Sequence 437631 from Patent EP1572962. JD431302 - Sequence 412326 from Patent EP1572962. JD037783 - Sequence 18807 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000302291.1, ENST00000302291.2, ENST00000302291.3, ENST00000302291.4, ENST00000302291.5, ENST00000302291.6, ENST00000302291.7, ENST00000302291.8, LUZP1_HUMAN, NM_001395462, Q5TH93, Q86V48, Q8N4X3, Q8TEH1, uc317mzw.1, uc317mzw.2 UCSC ID: ENST00000302291.9_10 Representative RNA: NM_001395462 Protein: Q86V48 (aka LUZP1_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.