Human Gene LTB4R2 (ENST00000533293.2_4) from GENCODE V47lift37
  Description: leukotriene B4 receptor 2, transcript variant 1 (from RefSeq NM_019839.5)
Gencode Transcript: ENST00000533293.2_4
Gencode Gene: ENSG00000213906.10_9
Transcript (Including UTRs)
   Position: hg19 chr14:24,779,346-24,781,244 Size: 1,899 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr14:24,779,871-24,780,947 Size: 1,077 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:24,779,346-24,781,244)mRNA (may differ from genome)Protein (358 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: LT4R2_HUMAN
DESCRIPTION: RecName: Full=Leukotriene B4 receptor 2; Short=LTB4-R 2; Short=LTB4-R2; AltName: Full=LTB4 receptor JULF2; AltName: Full=Leukotriene B4 receptor BLT2; AltName: Full=Seven transmembrane receptor BLTR2;
FUNCTION: Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Widely expressed.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CAUTION: It is uncertain whether Met-1 or Met-32 is the initiator.
SEQUENCE CAUTION: Sequence=BAB00610.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -34.00126-0.270 Picture PostScript Text
3' UTR -98.20297-0.331 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR003981 - Leukotriene_B4_rcpt
IPR003982 - Leukotriene_B4_typ-2_rcpt

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q9NPC1
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001632 leukotriene B4 receptor activity
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004974 leukotriene receptor activity
GO:0008528 G-protein coupled peptide receptor activity

Biological Process:
GO:0006935 chemotaxis
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0051546 keratinocyte migration
GO:0061737 leukotriene signaling pathway

Cellular Component:
GO:0005654 nucleoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AF277230 - Homo sapiens seven transmembrane receptor BLTR2 (BLTR2) mRNA, complete cds.
JD148146 - Sequence 129170 from Patent EP1572962.
JD165943 - Sequence 146967 from Patent EP1572962.
JD226665 - Sequence 207689 from Patent EP1572962.
AK304169 - Homo sapiens cDNA FLJ53958 complete cds, highly similar to Leukotriene B4 receptor 2.
JD090353 - Sequence 71377 from Patent EP1572962.
BC038437 - Homo sapiens leukotriene B4 receptor 2, mRNA (cDNA clone IMAGE:4753033).
AB032558 - Homo sapiens KPG_004 mRNA for G-protein coupled receptor, complete cds.
JD424379 - Sequence 405403 from Patent EP1572962.
JD190884 - Sequence 171908 from Patent EP1572962.
BC127643 - Homo sapiens leukotriene B4 receptor 2, mRNA (cDNA clone IMAGE:40116228), partial cds.
BC119674 - Homo sapiens leukotriene B4 receptor 2, mRNA (cDNA clone IMAGE:40116226), partial cds.
BC172240 - Synthetic construct Homo sapiens clone IMAGE:100068934, MGC:198945 leukotriene B4 receptor 2 (LTB4R2) mRNA, encodes complete protein.
BC172548 - Synthetic construct Homo sapiens clone IMAGE:100069242, MGC:199253 leukotriene B4 receptor 2 (LTB4R2) mRNA, encodes complete protein.
AB029892 - Homo sapiens hBLT2 mRNA for Leukotriene B4 receptor BLT2, complete cds.
AB044402 - Homo sapiens mRNA for LTB4 receptor JULF2, complete cds.
AF308571 - Homo sapiens hepatointestinal leukotriene B4 receptor mRNA, complete cds.
D89079 - Homo sapiens mRNA for leukotriene b4 receptor, complete cds.
U41070 - Human P2 purinergic receptor mRNA, complete cds.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9NPC1 (Reactome details) participates in the following event(s):

R-HSA-391941 BLT receptors can bind LTB4
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-391906 Leukotriene receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-391903 Eicosanoid ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-372790 Signaling by GPCR
R-HSA-500792 GPCR ligand binding
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: BLT2R, BLTR2, ENST00000533293.1, LT4R2_HUMAN, NM_019839, Q5KU28, Q9NPC1, Q9NPE5, uc324lhv.1, uc324lhv.2
UCSC ID: ENST00000533293.2_4
RefSeq Accession: NM_019839.5
Protein: Q9NPC1 (aka LT4R2_HUMAN or L4R2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.