Human Gene LSR (ENST00000605618.6_6) from GENCODE V47lift37
  Description: lipolysis stimulated lipoprotein receptor, transcript variant 2 (from RefSeq NM_205834.4)
Gencode Transcript: ENST00000605618.6_6
Gencode Gene: ENSG00000105699.17_14
Transcript (Including UTRs)
   Position: hg19 chr19:35,739,905-35,758,867 Size: 18,963 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr19:35,739,926-35,758,762 Size: 18,837 Coding Exon Count: 10 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther Names
GeneReviewsModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:35,739,905-35,758,867)mRNA (may differ from genome)Protein (601 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: LSR
Diseases sorted by gene-association score: deafness, autosomal recessive 42 (3), deafness, autosomal recessive 49 (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D013749 Tetrachlorodibenzodioxin
  • C495626 14-deoxy-11,12-didehydroandrographolide
  • C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
  • C016403 2,4-dinitrotoluene
  • C049584 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
  • C017906 3-dinitrobenzene
  • C009505 4,4'-diaminodiphenylmethane
  • D015127 9,10-Dimethyl-1,2-benzanthracene
  • D000643 Ammonium Chloride
  • D001554 Benzene
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 49.44 RPKM in Colon - Transverse
Total median expression: 589.59 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -7.4021-0.352 Picture PostScript Text
3' UTR -8.60105-0.082 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Descriptions from all associated GenBank mRNAs
  AK126834 - Homo sapiens cDNA FLJ44886 fis, clone BRAMY2040915, moderately similar to Homo sapiens liver-specific bHLH-Zip transcription factor (LISCH7).
BC047376 - Homo sapiens lipolysis stimulated lipoprotein receptor, mRNA (cDNA clone MGC:48312 IMAGE:5272128), complete cds.
AB527667 - Synthetic construct DNA, clone: pF1KB6169, Homo sapiens LSR gene for lipolysis stimulated lipoprotein receptor, without stop codon, in Flexi system.
KJ893946 - Synthetic construct Homo sapiens clone ccsbBroadEn_03340 LSR gene, encodes complete protein.
AF130366 - Homo sapiens LISCH protein mRNA, complete cds.
AK130367 - Homo sapiens cDNA FLJ26857 fis, clone PRS08213.
AK296618 - Homo sapiens cDNA FLJ55699 complete cds, highly similar to Homo sapiens liver-specific bHLH-Zip transcription factor (LISCH7), transcript variant 3, mRNA.
AK075426 - Homo sapiens cDNA PSEC0117 fis, clone PLACE1001904, moderately similar to LISCH protein.
BC004381 - Homo sapiens lipolysis stimulated lipoprotein receptor, mRNA (cDNA clone IMAGE:3641235), partial cds.
BC000015 - Homo sapiens lipolysis stimulated lipoprotein receptor, mRNA (cDNA clone IMAGE:3506628), partial cds.
LF207612 - JP 2014500723-A/15115: Polycomb-Associated Non-Coding RNAs.
LF367433 - JP 2014500723-A/174936: Polycomb-Associated Non-Coding RNAs.
MA603010 - JP 2018138019-A/174936: Polycomb-Associated Non-Coding RNAs.
MA443189 - JP 2018138019-A/15115: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000605618.1, ENST00000605618.2, ENST00000605618.3, ENST00000605618.4, ENST00000605618.5, LSR , NM_205834, S4R3V8, S4R3V8_HUMAN, uc327jeb.1, uc327jeb.2
UCSC ID: ENST00000605618.6_6
RefSeq Accession: NM_205834.4

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene LSR:
chol-liver-ov (Pediatric Genetic Cholestatic Liver Disease Overview)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.