ID:LRRC4_HUMAN DESCRIPTION: RecName: Full=Leucine-rich repeat-containing protein 4; AltName: Full=Brain tumor-associated protein BAG; AltName: Full=Nasopharyngeal carcinoma-associated gene 14 protein; AltName: Full=Netrin-G2 ligand; Short=NGL-2; Flags: Precursor; FUNCTION: Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays a important role for auditory synaptic responses. Involved in the suppression of glioma (By similarity). SUBUNIT: Interacts with NTNG2 (By similarity). Interacts with DLG4 (By similarity). Forms a complex with DLG4 and with NMDA receptors. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane (By similarity). Note=LRRC4 and DLG4 are interdependent for synaptic localization (By similarity). TISSUE SPECIFICITY: Specifically expressed in brain. DOMAIN: The last 4 C-terminal residues bind to the first 2 PDZ domains of DLG4 (By similarity). PTM: N-glycosylated (By similarity). SIMILARITY: Contains 1 Ig-like (immunoglobulin-like) domain. SIMILARITY: Contains 9 LRR (leucine-rich) repeats. SIMILARITY: Contains 1 LRRCT domain. SIMILARITY: Contains 1 LRRNT domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9HBW1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
