ID:RBTN2_HUMAN DESCRIPTION: RecName: Full=Rhombotin-2; AltName: Full=Cysteine-rich protein TTG-2; AltName: Full=LIM domain only protein 2; Short=LMO-2; AltName: Full=T-cell translocation protein 2; FUNCTION: Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state. SUBUNIT: Interacts via its LIM domains with ELF2 and LBD1. Also interacts with basic helix-loop-helix protein TAL1/SCL and can assemble in a complex with LMO2 and TAL1/SCL (By similarity). Interacts with BEX2 and KDM5A. INTERACTION: Q04206:RELA; NbExp=3; IntAct=EBI-739696, EBI-73886; SUBCELLULAR LOCATION: Nucleus (Potential). DOMAIN: The second LIM zinc-binding domain interacts with KDM5A. DISEASE: Note=A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD. SIMILARITY: Contains 2 LIM zinc-binding domains. SEQUENCE CAUTION: Sequence=AAF98804.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAH73973.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=CAA43430.1; Type=Frameshift; Positions=Several; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/RBTN2ID34.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P25791
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001102 RNA polymerase II activating transcription factor binding GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0005515 protein binding GO:0043425 bHLH transcription factor binding GO:0046872 metal ion binding GO:0048037 cofactor binding GO:0070888 E-box binding
Biological Process: GO:0007275 multicellular organism development GO:0042789 mRNA transcription from RNA polymerase II promoter GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0097067 cellular response to thyroid hormone stimulus GO:1902036 regulation of hematopoietic stem cell differentiation
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
