Human Gene LIN37 (ENST00000301159.14_4) from GENCODE V47lift37
  Description: lin-37 DREAM MuvB core complex component, transcript variant 3 (from RefSeq NR_163146.1)
Gencode Transcript: ENST00000301159.14_4
Gencode Gene: ENSG00000267796.8_8
Transcript (Including UTRs)
   Position: hg19 chr19:36,239,477-36,245,420 Size: 5,944 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr19:36,239,626-36,245,375 Size: 5,750 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:36,239,477-36,245,420)mRNA (may differ from genome)Protein (246 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: LIN37_HUMAN
DESCRIPTION: RecName: Full=Protein lin-37 homolog; AltName: Full=Antolefinin;
SUBUNIT: Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.
INTERACTION: Q8IYF3:TEX11; NbExp=2; IntAct=EBI-748884, EBI-742397;
SEQUENCE CAUTION: Sequence=AAB81199.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.59 RPKM in Brain - Cerebellum
Total median expression: 95.16 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -49.10149-0.330 Picture PostScript Text
3' UTR -3.1045-0.069 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF15306 - LIN37

SCOP Domains:
47095 - HMG-box

ModBase Predicted Comparative 3D Structure on Q96GY3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0007049 cell cycle
GO:0051726 regulation of cell cycle

Cellular Component:
GO:0005654 nucleoplasm
GO:0017053 transcriptional repressor complex


-  Descriptions from all associated GenBank mRNAs
  BC008939 - Homo sapiens lin-37 homolog (C. elegans), mRNA (cDNA clone IMAGE:2989481).
AK301992 - Homo sapiens cDNA FLJ56586 complete cds, highly similar to Antolefinin.
AK293116 - Homo sapiens cDNA FLJ76594 complete cds, highly similar to Homo sapiens protein F25965, mRNA.
BC009071 - Homo sapiens lin-37 homolog (C. elegans), mRNA (cDNA clone MGC:9505 IMAGE:3872616), complete cds.
AB527782 - Synthetic construct DNA, clone: pF1KB5849, Homo sapiens LIN37 gene for lin-37 homolog, without stop codon, in Flexi system.
CU679243 - Synthetic construct Homo sapiens gateway clone IMAGE:100016877 5' read LIN37 mRNA.
HQ447111 - Synthetic construct Homo sapiens clone IMAGE:100070397; CCSB002864_01 lin-37 homolog (C. elegans) (LIN37) gene, encodes complete protein.
KJ894291 - Synthetic construct Homo sapiens clone ccsbBroadEn_03685 LIN37 gene, encodes complete protein.
KJ902897 - Synthetic construct Homo sapiens clone ccsbBroadEn_12291 hypothetical protein, encodes complete protein.
AF162447 - Homo sapiens MSTP064 mRNA, complete cds.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q96GY3 (Reactome details) participates in the following event(s):

R-HSA-1362270 Phosphorylation of LIN52 component of MuvB by DYRK1A
R-HSA-4088306 FOXM1 binds PLK1 promoter
R-HSA-4088307 FOXM1 binds CCNB1 promoter
R-HSA-4088309 FOXM1 binds CCNB2 promoter
R-HSA-1362261 p130 (RBL2) associates with MuvB to form DREAM complex
R-HSA-8964465 DREAM complex binds the PCNA gene promoter
R-HSA-8964471 DREAM complex binds the CDC25A gene promoter
R-HSA-8964475 DREAM complex binds the TOP2A gene promoter
R-HSA-8964482 DREAM complex binds the E2F1 gene promoter
R-HSA-8964492 DREAM complex binds the RBL1 gene promoter
R-HSA-8964498 DREAM complex binds the CDC6 gene promoter
R-HSA-1538133 G0 and Early G1
R-HSA-156711 Polo-like kinase mediated events
R-HSA-453279 Mitotic G1-G1/S phases
R-HSA-69275 G2/M Transition
R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-1640170 Cell Cycle

-  Other Names for This Gene
  Alternate Gene Symbols: A8KAQ1, ENST00000301159.1, ENST00000301159.10, ENST00000301159.11, ENST00000301159.12, ENST00000301159.13, ENST00000301159.2, ENST00000301159.3, ENST00000301159.4, ENST00000301159.5, ENST00000301159.6, ENST00000301159.7, ENST00000301159.8, ENST00000301159.9, LIN37_HUMAN, MSTP064, NR_163146, O14557, Q7Z2T9, Q96GY3, uc317msz.1, uc317msz.2
UCSC ID: ENST00000301159.14_4
RefSeq Accession: NM_019104.3
Protein: Q96GY3 (aka LIN37_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.