Human Gene LHFPL2 (ENST00000380345.7_8) from GENCODE V47lift37

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Description: LHFPL tetraspan subfamily member 2 (from RefSeq NM_005779.3)
Gencode Transcript: ENST00000380345.7_8
Gencode Gene: ENSG00000145685.14_11
Transcript (Including UTRs)
Position: hg19 chr5:77,781,053-77,944,595 Size: 163,543 Total Exon Count: 5 Strand: -
Coding Region
Position: hg19 chr5:77,784,720-77,806,036 Size: 21,317 Coding Exon Count: 2

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr5:77,781,053-77,944,595)			mRNA (may differ from genome)		Protein (228 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: LHPL2_HUMAN DESCRIPTION: RecName: Full=Lipoma HMGIC fusion partner-like 2 protein; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). TISSUE SPECIFICITY: Expressed in all tissues and cell lines examined except brain and peripheral blood leukocytes. SIMILARITY: Belongs to the LHFP family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001564 Benzo(a)pyrene D016572 Cyclosporine D010634 Phenobarbital C009505 4,4'-diaminodiphenylmethane D016604 Aflatoxin B1 D000535 Aluminum D001554 Benzene D002117 Calcitriol D002251 Carbon Tetrachloride D003993 Dibutyl Phthalate more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 8.81 RPKM in Minor Salivary Gland Total median expression: 223.86 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-243.70	623	-0.391	Picture	PostScript	Text
3' UTR	-1026.20	3667	-0.280	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR019372 - Lipome_HGMIC_fus_partner-like

Pfam Domains:
PF10242 - Lipoma HMGIC fusion partner-like protein
PF13903 - PMP-22/EMP/MP20/Claudin tight junction

ModBase Predicted Comparative 3D Structure on Q6ZUX7


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details		Gene Details
Gene Sorter	Gene Sorter		Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003674 molecular_function Biological Process: GO:0002576 platelet degranulation GO:0007338 single fertilization GO:0008150 biological_process GO:0046545 development of primary female sexual characteristics GO:0046546 development of primary male sexual characteristics GO:1905516 positive regulation of fertilization Cellular Component: GO:0005575 cellular_component GO:0005886 plasma membrane GO:0016020 membrane GO:0016021 integral component of membrane GO:0031092 platelet alpha granule membrane

Descriptions from all associated GenBank mRNAs


	AY309920 - Homo sapiens HMGIC fusion partner-like 2 (LHFPL2) mRNA, complete cds. D86961 - Homo sapiens mRNA for KIAA0206 gene, partial cds. CR936660 - Homo sapiens mRNA; cDNA DKFZp781E0375 (from clone DKFZp781E0375). JD330369 - Sequence 311393 from Patent EP1572962. JD166072 - Sequence 147096 from Patent EP1572962. JD450460 - Sequence 431484 from Patent EP1572962. JD354894 - Sequence 335918 from Patent EP1572962. JD118886 - Sequence 99910 from Patent EP1572962. JD082952 - Sequence 63976 from Patent EP1572962. JD049193 - Sequence 30217 from Patent EP1572962. JD491293 - Sequence 472317 from Patent EP1572962. JD509934 - Sequence 490958 from Patent EP1572962. JD226013 - Sequence 207037 from Patent EP1572962. JD479846 - Sequence 460870 from Patent EP1572962. JD553812 - Sequence 534836 from Patent EP1572962. JD037120 - Sequence 18144 from Patent EP1572962. JD169471 - Sequence 150495 from Patent EP1572962. JD061831 - Sequence 42855 from Patent EP1572962. JD534218 - Sequence 515242 from Patent EP1572962. JD302167 - Sequence 283191 from Patent EP1572962. JD315965 - Sequence 296989 from Patent EP1572962. JD322176 - Sequence 303200 from Patent EP1572962. BC136335 - Homo sapiens lipoma HMGIC fusion partner-like 2, mRNA (cDNA clone MGC:167945 IMAGE:9020322), complete cds. BC136336 - Homo sapiens lipoma HMGIC fusion partner-like 2, mRNA (cDNA clone MGC:167946 IMAGE:9020323), complete cds. JD101295 - Sequence 82319 from Patent EP1572962. JD219373 - Sequence 200397 from Patent EP1572962. JD317167 - Sequence 298191 from Patent EP1572962. JD377136 - Sequence 358160 from Patent EP1572962. JD467163 - Sequence 448187 from Patent EP1572962. JD185165 - Sequence 166189 from Patent EP1572962. JD411477 - Sequence 392501 from Patent EP1572962. JD323530 - Sequence 304554 from Patent EP1572962. JD046293 - Sequence 27317 from Patent EP1572962. JD294806 - Sequence 275830 from Patent EP1572962. JD184406 - Sequence 165430 from Patent EP1572962. JD064846 - Sequence 45870 from Patent EP1572962. JD367801 - Sequence 348825 from Patent EP1572962. AK125227 - Homo sapiens cDNA FLJ43237 fis, clone HCHON2005921. JD140312 - Sequence 121336 from Patent EP1572962. JD073433 - Sequence 54457 from Patent EP1572962. JD499175 - Sequence 480199 from Patent EP1572962. JD553141 - Sequence 534165 from Patent EP1572962. JD254146 - Sequence 235170 from Patent EP1572962. JD370450 - Sequence 351474 from Patent EP1572962. JD506878 - Sequence 487902 from Patent EP1572962. JD496801 - Sequence 477825 from Patent EP1572962. JD523938 - Sequence 504962 from Patent EP1572962. JD508720 - Sequence 489744 from Patent EP1572962. JD551974 - Sequence 532998 from Patent EP1572962. JD490476 - Sequence 471500 from Patent EP1572962. JD313240 - Sequence 294264 from Patent EP1572962. JD052786 - Sequence 33810 from Patent EP1572962. JD079329 - Sequence 60353 from Patent EP1572962. KJ892949 - Synthetic construct Homo sapiens clone ccsbBroadEn_02343 LHFPL2 gene, encodes complete protein. DQ590425 - Homo sapiens piRNA piR-57537, complete sequence. JD555868 - Sequence 536892 from Patent EP1572962. JD075344 - Sequence 56368 from Patent EP1572962. JD371188 - Sequence 352212 from Patent EP1572962. JD221789 - Sequence 202813 from Patent EP1572962. JD141601 - Sequence 122625 from Patent EP1572962. JD071615 - Sequence 52639 from Patent EP1572962. AK091868 - Homo sapiens cDNA FLJ34549 fis, clone HLUNG2009253. AX747229 - Sequence 754 from Patent EP1308459. JD290723 - Sequence 271747 from Patent EP1572962. JD281569 - Sequence 262593 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q6ZUX7 (Reactome details) participates in the following event(s): R-HSA-481044 Surface deployment of platelet alpha granule membrane components R-HSA-114608 Platelet degranulation R-HSA-76005 Response to elevated platelet cytosolic Ca2+ R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-109582 Hemostasis

Other Names for This Gene


	Alternate Gene Symbols: B2RMQ6, ENST00000380345.1, ENST00000380345.2, ENST00000380345.3, ENST00000380345.4, ENST00000380345.5, ENST00000380345.6, KIAA0206, LHFPL2 , LHPL2_HUMAN, NM_005779, Q6ZUX7, Q7Z5P0, Q92605, uc318pnr.1, uc318pnr.2 UCSC ID: ENST00000380345.7_8 RefSeq Accession: NM_005779.3 Protein: Q6ZUX7 (aka LHPL2_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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