ID:LECT1_HUMAN DESCRIPTION: RecName: Full=Leukocyte cell-derived chemotaxin 1; Contains: RecName: Full=Chondrosurfactant protein; Short=CH-SP; Contains: RecName: Full=Chondromodulin-1; AltName: Full=Chondromodulin-I; Short=ChM-I; Flags: Precursor; FUNCTION: Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization. SUBCELLULAR LOCATION: Chondromodulin-1: Secreted. Note=Accumulated in the inter-territorial matrix of cartilage. SUBCELLULAR LOCATION: Chondrosurfactant protein: Endomembrane system; Single-pass membrane protein (Potential). TISSUE SPECIFICITY: Detected in cartilage and cardiac valves (at protein level). Detected in the laminae fibrosa, spongiosa and ventricularis layers of normal cardiac valves (at protein level). Expression is decreased cardiac valves of patients with valvular heart disease (at protein level). Weakly expressed in chondrosarcoma. DEVELOPMENTAL STAGE: Expressed at 9 weeks in developing cartilagenous bone rudiments. PTM: After cleavage, the post-translationally modified ChM-I is secreted as a glycoprotein. SIMILARITY: Belongs to the chondromodulin-1 family. SIMILARITY: Contains 1 BRICHOS domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75829
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Biological Process: GO:0001501 skeletal system development GO:0006029 proteoglycan metabolic process GO:0007275 multicellular organism development GO:0016525 negative regulation of angiogenesis GO:0030154 cell differentiation GO:0051216 cartilage development
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
