Human Gene KRTAP3-1 (ENST00000391588.3_6) from GENCODE V47lift37 |
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 Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: KRA31_HUMAN
DESCRIPTION: RecName: Full=Keratin-associated protein 3-1; AltName: Full=High sulfur keratin-associated protein 3.1; AltName: Full=Keratin-associated protein 3.1;
FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.
SUBUNIT: Interacts with hair keratins.
SIMILARITY: Belongs to the KRTAP type 3 family.
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Primer design for this transcript
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Comparative Toxicogenomics Database (CTD)
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The following chemicals interact with this gene
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 Common Gene Haplotype Alleles
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Press "+" in the title bar above to open this section.
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure
IPR007659 - Keratin_matx
Pfam Domains:
PF04579 - Keratin, high-sulphur matrix protein
ModBase Predicted Comparative 3D Structure on Q9BYR8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Descriptions from all associated GenBank mRNAs
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AJ406931 - Homo sapiens mRNA for keratin associated protein 3.1 (KRTAP3.1 gene).
JD092621 - Sequence 73645 from Patent EP1572962.
JD341464 - Sequence 322488 from Patent EP1572962.
JD121198 - Sequence 102222 from Patent EP1572962.
BC113078 - Homo sapiens keratin associated protein 3-1, mRNA (cDNA clone MGC:134860 IMAGE:40069150), complete cds.
BC113077 - Homo sapiens keratin associated protein 3-1, mRNA (cDNA clone MGC:134859 IMAGE:40069149), complete cds.
JD532333 - Sequence 513357 from Patent EP1572962.
KJ894910 - Synthetic construct Homo sapiens clone ccsbBroadEn_04304 KRTAP3-1 gene, encodes complete protein.
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Biochemical and Signaling Pathways
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Other Names for This Gene
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Alternate Gene Symbols: ENST00000391588.1, ENST00000391588.2, KAP3.1, KRA31_HUMAN, KRTAP3.1, NM_031958, Q14DM4, Q9BYR8, uc318ums.1, uc318ums.2
UCSC ID: ENST00000391588.3_6
RefSeq Accession: NM_031958.2
Protein: Q9BYR8
(aka KRA31_HUMAN or KR31_HUMAN)
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Gene Model Information
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for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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Click here
for details on how this gene model was made and data restrictions if any.
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US Server
