Human Gene KRTAP17-1 (ENST00000334202.5_6) from GENCODE V47lift37
  Description: keratin associated protein 17-1 (from RefSeq NM_031964.2)
Gencode Transcript: ENST00000334202.5_6
Gencode Gene: ENSG00000186860.5_8
Transcript (Including UTRs)
   Position: hg19 chr17:39,471,164-39,471,962 Size: 799 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg19 chr17:39,471,585-39,471,902 Size: 318 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:39,471,164-39,471,962)mRNA (may differ from genome)Protein (105 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KR171_HUMAN
DESCRIPTION: RecName: Full=Keratin-associated protein 17-1; AltName: Full=Keratin-associated protein 16.1;
FUNCTION: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.
SUBUNIT: Interacts with hair keratins (By similarity).

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.12 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 0.30 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -23.5060-0.392 Picture PostScript Text
3' UTR -114.30421-0.271 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q9BYP8
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0031424 keratinization

Cellular Component:
GO:0005829 cytosol
GO:0005882 intermediate filament


-  Descriptions from all associated GenBank mRNAs
  BC146276 - Synthetic construct Homo sapiens clone IMAGE:100015204, MGC:180246 keratin associated protein 17-1 (KRTAP17-1) mRNA, encodes complete protein.
AJ406952 - Homo sapiens mRNA for keratin associated protein 16.1 (KRTAP16.1 gene).
BC069078 - Homo sapiens keratin associated protein 17-1, mRNA (cDNA clone IMAGE:7216892), complete cds.
JD417028 - Sequence 398052 from Patent EP1572962.
JD563309 - Sequence 544333 from Patent EP1572962.
JD451917 - Sequence 432941 from Patent EP1572962.
JD290399 - Sequence 271423 from Patent EP1572962.
JD096018 - Sequence 77042 from Patent EP1572962.
BC069297 - Homo sapiens keratin associated protein 17-1, mRNA (cDNA clone IMAGE:7262696), complete cds.
JD297692 - Sequence 278716 from Patent EP1572962.
JD321390 - Sequence 302414 from Patent EP1572962.
BC146560 - Synthetic construct Homo sapiens clone IMAGE:100014844, MGC:180143 keratin associated protein 17-1 (KRTAP17-1) mRNA, encodes complete protein.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9BYP8 (Reactome details) participates in the following event(s):

R-HSA-6805567 Keratinization
R-HSA-1266738 Developmental Biology

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000334202.1, ENST00000334202.2, ENST00000334202.3, ENST00000334202.4, KAP17.1, KR171_HUMAN, KRTAP16.1, NM_031964, Q9BYP8, uc317twn.1, uc317twn.2
UCSC ID: ENST00000334202.5_6
RefSeq Accession: NM_031964.2
Protein: Q9BYP8 (aka KR171_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.