Human Gene KRT23 (ENST00000209718.8_6) from GENCODE V47lift37
  Description: keratin 23, transcript variant 1 (from RefSeq NM_015515.5)
Gencode Transcript: ENST00000209718.8_6
Gencode Gene: ENSG00000108244.17_15
Transcript (Including UTRs)
   Position: hg19 chr17:39,078,952-39,093,898 Size: 14,947 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr17:39,079,241-39,092,855 Size: 13,615 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:39,078,952-39,093,898)mRNA (may differ from genome)Protein (422 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: K1C23_HUMAN
DESCRIPTION: RecName: Full=Keratin, type I cytoskeletal 23; AltName: Full=Cytokeratin-23; Short=CK-23; AltName: Full=Keratin-23; Short=K23;
SUBUNIT: Heterotetramer of two type I and two type II keratins (By similarity).
MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
SIMILARITY: Belongs to the intermediate filament family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: KRT23
Diseases sorted by gene-association score: colonic benign neoplasm (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 82.89 RPKM in Skin - Sun Exposed (Lower leg)
Total median expression: 270.25 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -222.30651-0.341 Picture PostScript Text
3' UTR -53.30289-0.184 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016044 - F
IPR001664 - IF
IPR018039 - Intermediate_filament_CS
IPR002957 - Keratin_I

Pfam Domains:
PF00038 - Intermediate filament protein

SCOP Domains:
64593 - Intermediate filament protein, coiled coil region

ModBase Predicted Comparative 3D Structure on Q9C075
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005198 structural molecule activity

Biological Process:
GO:0031424 keratinization
GO:0070268 cornification

Cellular Component:
GO:0005829 cytosol
GO:0005882 intermediate filament


-  Descriptions from all associated GenBank mRNAs
  AK289449 - Homo sapiens cDNA FLJ78494 complete cds, highly similar to Homo sapiens keratin 23 (histone deacetylase inducible) (KRT23), transcript variant 1, mRNA.
AF102848 - Homo sapiens keratin 23 (KRT23) mRNA, complete cds.
AK002047 - Homo sapiens cDNA FLJ11185 fis, clone PLACE1007511, weakly similar to KERATIN, TYPE I CYTOSKELETAL 19.
AK225866 - Homo sapiens mRNA for keratin 23 isoform a variant, clone: FCC124G03.
BC028356 - Homo sapiens keratin 23 (histone deacetylase inducible), mRNA (cDNA clone MGC:26158 IMAGE:4838347), complete cds.
AK302109 - Homo sapiens cDNA FLJ50284 complete cds, highly similar to Keratin, type I cytoskeletal 23.
AL117538 - Homo sapiens mRNA; cDNA DKFZp434G032 (from clone DKFZp434G032).
JD258604 - Sequence 239628 from Patent EP1572962.
JD490689 - Sequence 471713 from Patent EP1572962.
DQ891640 - Synthetic construct clone IMAGE:100004270; FLH178890.01X; RZPDo839A05130D keratin 23 (histone deacetylase inducible) (KRT23) gene, encodes complete protein.
AK314604 - Homo sapiens cDNA, FLJ95443, highly similar to Homo sapiens keratin 23 (histone deacetylase inducible) (KRT23), transcript variant 2, mRNA.
KJ898580 - Synthetic construct Homo sapiens clone ccsbBroadEn_07974 KRT23 gene, encodes complete protein.
DQ894829 - Synthetic construct Homo sapiens clone IMAGE:100009289; FLH178886.01L; RZPDo839A05129D keratin 23 (histone deacetylase inducible) (KRT23) gene, encodes complete protein.
AK310880 - Homo sapiens cDNA, FLJ17922.
JD437495 - Sequence 418519 from Patent EP1572962.
JD414213 - Sequence 395237 from Patent EP1572962.
JD172714 - Sequence 153738 from Patent EP1572962.
JD303370 - Sequence 284394 from Patent EP1572962.
JD335846 - Sequence 316870 from Patent EP1572962.
JD211301 - Sequence 192325 from Patent EP1572962.
JD313459 - Sequence 294483 from Patent EP1572962.
JD044696 - Sequence 25720 from Patent EP1572962.
JD272855 - Sequence 253879 from Patent EP1572962.
JD300667 - Sequence 281691 from Patent EP1572962.
JD086505 - Sequence 67529 from Patent EP1572962.
JD047926 - Sequence 28950 from Patent EP1572962.
JD397600 - Sequence 378624 from Patent EP1572962.
JD095487 - Sequence 76511 from Patent EP1572962.
JD097243 - Sequence 78267 from Patent EP1572962.
JD491822 - Sequence 472846 from Patent EP1572962.
JD519524 - Sequence 500548 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9C075 (Reactome details) participates in the following event(s):

R-HSA-6805546 Keratin type I binds keratin type II
R-HSA-6805573 Keratin type I/type II heterodimers form tetramers
R-HSA-6806613 Keratin tetramers bind to form unit length filaments
R-HSA-6805567 Keratinization
R-HSA-1266738 Developmental Biology

-  Other Names for This Gene
  Alternate Gene Symbols: A8K084, B7Z7J2, ENST00000209718.1, ENST00000209718.2, ENST00000209718.3, ENST00000209718.4, ENST00000209718.5, ENST00000209718.6, ENST00000209718.7, I3L3Q6, K1C23_HUMAN, NM_015515, Q9C075, Q9NUR6, uc317ckq.1, uc317ckq.2
UCSC ID: ENST00000209718.8_6
RefSeq Accession: NM_015515.5
Protein: Q9C075 (aka K1C23_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.