ID:NKG2A_HUMAN DESCRIPTION: RecName: Full=NKG2-A/NKG2-B type II integral membrane protein; AltName: Full=CD159 antigen-like family member A; AltName: Full=NK cell receptor A; AltName: Full=NKG2-A/B-activating NK receptor; AltName: CD_antigen=CD159a; FUNCTION: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. SUBUNIT: Can form disulfide-bonded heterodimer with CD94. SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein. TISSUE SPECIFICITY: Natural killer cells. SIMILARITY: Contains 1 C-type lectin domain. WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; Note=NKG-2A; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_245";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P26715
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004888 transmembrane signaling receptor activity GO:0005515 protein binding GO:0023024 MHC class I protein complex binding GO:0030246 carbohydrate binding GO:1990405 protein antigen binding
AK310992 - Homo sapiens cDNA, FLJ18034. X54867 - Human mRNA for NKG2-A gene. X54868 - Human mRNA for NKG2-B gene. AF461812 - Homo sapiens NKG2A mRNA, complete cds. BC053840 - Homo sapiens killer cell lectin-like receptor subfamily C, member 1, mRNA (cDNA clone MGC:59791 IMAGE:5484921), complete cds. BC012550 - Homo sapiens killer cell lectin-like receptor subfamily C, member 1, mRNA (cDNA clone MGC:13374 IMAGE:4042168), complete cds. JD145807 - Sequence 126831 from Patent EP1572962. JD310624 - Sequence 291648 from Patent EP1572962. DQ892740 - Synthetic construct clone IMAGE:100005370; FLH189265.01X; RZPDo839D0474D killer cell lectin-like receptor subfamily C, member 1 (KLRC1) gene, encodes complete protein. CU680356 - Synthetic construct Homo sapiens gateway clone IMAGE:100023354 5' read KLRC1 mRNA. KJ891516 - Synthetic construct Homo sapiens clone ccsbBroadEn_00910 KLRC1 gene, encodes complete protein. KJ897100 - Synthetic construct Homo sapiens clone ccsbBroadEn_06494 KLRC1 gene, encodes complete protein. DQ895986 - Synthetic construct Homo sapiens clone IMAGE:100010446; FLH189261.01L; RZPDo839D0464D killer cell lectin-like receptor subfamily C, member 1 (KLRC1) gene, encodes complete protein. DQ896730 - Synthetic construct Homo sapiens clone IMAGE:100011190; FLH263672.01L; RZPDo839D0981D killer cell lectin-like receptor subfamily C, member 1 (KLRC1) gene, encodes complete protein. AB529160 - Synthetic construct DNA, clone: pF1KB6948, Homo sapiens KLRC1 gene for killer cell lectin-like receptor subfamily C, member 1, without stop codon, in Flexi system. CU691034 - Synthetic construct Homo sapiens gateway clone IMAGE:100022388 5' read KLRC1 mRNA. JD107000 - Sequence 88024 from Patent EP1572962. JD433519 - Sequence 414543 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_nkcellsPathway - Ras-Independent pathway in NK cell-mediated cytotoxicity
Reactome (by CSHL, EBI, and GO)
Protein P26715 (Reactome details) participates in the following event(s):
R-HSA-199062 KLRC1:KLRD1 heterodimer interacts with HLA-E R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-1280218 Adaptive Immune System R-HSA-168256 Immune System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
