Human Gene KLK4 (ENST00000324041.6_8) from GENCODE V47lift37
  Description: kallikrein related peptidase 4, transcript variant 1 (from RefSeq NM_004917.5)
Gencode Transcript: ENST00000324041.6_8
Gencode Gene: ENSG00000167749.12_10
Transcript (Including UTRs)
   Position: hg19 chr19:51,409,607-51,414,651 Size: 5,045 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr19:51,410,190-51,413,994 Size: 3,805 Coding Exon Count: 5 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:51,409,607-51,414,651)mRNA (may differ from genome)Protein (254 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: KLK4
Diseases sorted by gene-association score: amelogenesis imperfecta, type iia1* (1000), amelogenesis imperfecta hypomaturation type* (165), amelogenesis imperfecta (15), parotid disease (9), spermatocele (7), malignant essential hypertension (6), periodontosis (5), salivary gland disease (5), male reproductive organ cancer (4), granulomatous hepatitis (4), nodular nonsuppurative panniculitis (4), ovarian cancer, somatic (3), prostate cancer (2), reproductive organ cancer (1), hypertension, essential (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 219.47 RPKM in Prostate
Total median expression: 229.54 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -21.6068-0.318 Picture PostScript Text
3' UTR -138.20583-0.237 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Descriptions from all associated GenBank mRNAs
  KM576752 - Homo sapiens clone KLK4-KRSP1_K3-K4 mRNA sequence.
KM576748 - Homo sapiens clone KLK4-KRSP1_K1-K3 mRNA sequence.
KM576749 - Homo sapiens clone KLK4-KRSP1_K1-K4 mRNA sequence.
KM576750 - Homo sapiens clone KLK4-KRSP1_K5middle2-K4 mRNA sequence.
KM576751 - Homo sapiens clone KLK4-KRSP1_K5middle-K4 mRNA sequence.
AF126401 - Homo sapiens enamel matrix serine proteinase 1 mRNA, partial cds.
AF113140 - Homo sapiens serine protease prostase mRNA, complete cds.
JD398440 - Sequence 379464 from Patent EP1572962.
JD335897 - Sequence 316921 from Patent EP1572962.
JD398446 - Sequence 379470 from Patent EP1572962.
JD041609 - Sequence 22633 from Patent EP1572962.
JD335902 - Sequence 316926 from Patent EP1572962.
JD398441 - Sequence 379465 from Patent EP1572962.
JD414032 - Sequence 395056 from Patent EP1572962.
JD398442 - Sequence 379466 from Patent EP1572962.
JD335900 - Sequence 316924 from Patent EP1572962.
JD398441 - Sequence 379465 from Patent EP1572962.
JD414032 - Sequence 395056 from Patent EP1572962.
JD398442 - Sequence 379466 from Patent EP1572962.
JD335900 - Sequence 316924 from Patent EP1572962.
JD398441 - Sequence 379465 from Patent EP1572962.
JD150389 - Sequence 131413 from Patent EP1572962.
JD457192 - Sequence 438216 from Patent EP1572962.
JD147572 - Sequence 128596 from Patent EP1572962.
AX052877 - Sequence 11 from Patent WO0071711.
AF259964 - Homo sapiens clone L7 ARM1 mRNA, complete cds.
AF259965 - Homo sapiens clone E13 ARM1 mRNA, complete cds.
JD439574 - Sequence 420598 from Patent EP1572962.
BC096175 - Homo sapiens kallikrein-related peptidase 4, mRNA (cDNA clone MGC:116826 IMAGE:40003672), complete cds.
BC096176 - Homo sapiens kallikrein-related peptidase 4, mRNA (cDNA clone IMAGE:40003675), complete cds.
BC096177 - Homo sapiens kallikrein-related peptidase 4, mRNA (cDNA clone MGC:116828 IMAGE:40003676), complete cds.
BC096178 - Homo sapiens kallikrein-related peptidase 4, mRNA (cDNA clone MGC:116829 IMAGE:40003677), complete cds.
BC069403 - Homo sapiens kallikrein-related peptidase 4, mRNA (cDNA clone MGC:96914 IMAGE:7262123), complete cds.
BC069489 - Homo sapiens kallikrein-related peptidase 4, mRNA (cDNA clone MGC:96938 IMAGE:7262147), complete cds.
BC069325 - Homo sapiens kallikrein-related peptidase 4, mRNA (cDNA clone MGC:96902 IMAGE:7262111), complete cds.
BC069429 - Homo sapiens kallikrein-related peptidase 4, mRNA (cDNA clone MGC:96926 IMAGE:7262135), complete cds.
AF259966 - Homo sapiens clone ARM1 ARM1 mRNA, complete cds.
AF259970 - Homo sapiens ARM1 mRNA, alternatively spliced, complete cds.
AF259971 - Homo sapiens ARM1 mRNA, alternatively spliced, complete cds.
AX052874 - Sequence 8 from Patent WO0071711.
AX052875 - Sequence 9 from Patent WO0071711.
AX052876 - Sequence 10 from Patent WO0071711.
AF259969 - Homo sapiens prostase mRNA, complete cds.
AY923170 - Homo sapiens kallikrein 4 (KLK4) mRNA, complete cds, alternatively spliced.
HQ448390 - Synthetic construct Homo sapiens clone IMAGE:100071817; CCSB013815_01 kallikrein-related peptidase 4 (KLK4) gene, encodes complete protein.
KJ898057 - Synthetic construct Homo sapiens clone ccsbBroadEn_07451 KLK4 gene, encodes complete protein.
AX052880 - Sequence 14 from Patent WO0071711.
AK309958 - Homo sapiens cDNA, FLJ99999.
CU686804 - Synthetic construct Homo sapiens gateway clone IMAGE:100022553 5' read KLK4 mRNA.
AF259967 - Homo sapiens clone 5#3 ARM1 mRNA, partial cds.
AX052878 - Sequence 12 from Patent WO0071711.
AX052879 - Sequence 13 from Patent WO0071711.
AF259968 - Homo sapiens clone 5#6 ARM1 mRNA, partial cds.
AF464755 - Homo sapiens kallikrein (KLK4) mRNA, partial cds.
MN037411 - Homo sapiens KLK4-KLKP1 fusion protein (KLK4/KLKP1 fusion) mRNA, complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: A0A0C4DFQ5, A0A0C4DFQ5_HUMAN, ENST00000324041.1, ENST00000324041.2, ENST00000324041.3, ENST00000324041.4, ENST00000324041.5, hCG_1641510 , KLK4 , KLNB1 , NM_004917, uc317rou.1, uc317rou.2
UCSC ID: ENST00000324041.6_8
RefSeq Accession: NM_004917.5

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.