Human Gene KLC3 (ENST00000391946.7_8) from GENCODE V47lift37
  Description: kinesin light chain 3 (from RefSeq NM_177417.3)
Gencode Transcript: ENST00000391946.7_8
Gencode Gene: ENSG00000104892.17_14
Transcript (Including UTRs)
   Position: hg19 chr19:45,844,008-45,854,777 Size: 10,770 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg19 chr19:45,848,800-45,854,615 Size: 5,816 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:45,844,008-45,854,777)mRNA (may differ from genome)Protein (504 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KLC3_HUMAN
DESCRIPTION: RecName: Full=Kinesin light chain 3; AltName: Full=KLC2-like; AltName: Full=kinesin light chain 2;
FUNCTION: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.
SUBUNIT: Oligomer composed of two heavy chains and two light chains. Associates with microtubulin in an ATP-dependent manner. Interacts with KIF5C and ODF1 (By similarity).
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (Probable). Note=Elongating spermatid tail midpiece, localized in outer dense fibers (ODFs) and associates with mitochondria (By similarity).
DOMAIN: The heptad repeat (HR) motif is sufficient for interaction with kinesin heavy (KHL) chains and ODF1. The TPR region is involved in mitochondrial binding (By similarity).
SIMILARITY: Belongs to the kinesin light chain family.
SIMILARITY: Contains 5 TPR repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: KLC3
Diseases sorted by gene-association score: spoan syndrome (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 31.02 RPKM in Skin - Not Sun Exposed (Suprapubic)
Total median expression: 83.19 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -51.60105-0.491 Picture PostScript Text
3' UTR -68.00162-0.420 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002151 - Kinesin_light
IPR015390 - Rabaptin_Rab5-bd_dom
IPR001440 - TPR-1
IPR013026 - TPR-contain_dom
IPR011990 - TPR-like_helical
IPR019734 - TPR_repeat

Pfam Domains:
PF00515 - Tetratricopeptide repeat
PF01535 - PPR repeat
PF07721 - Tetratricopeptide repeat
PF13176 - Tetratricopeptide repeat
PF13181 - Tetratricopeptide repeat
PF13374 - Tetratricopeptide repeat
PF13424 - Tetratricopeptide repeat
PF17874 - MalT-like TPR region

SCOP Domains:
81901 - HCP-like
48439 - Protein prenylyltransferase
48445 - 14-3-3 protein
48452 - TPR-like
116846 - MIT domain
58050 - N-terminal coiled coil domain from apc
57997 - Tropomyosin

ModBase Predicted Comparative 3D Structure on Q6P597
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003777 microtubule motor activity
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0019894 kinesin binding

Biological Process:
GO:0008088 axo-dendritic transport

Cellular Component:
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0031514 motile cilium
GO:0035253 ciliary rootlet
GO:0043005 neuron projection


-  Descriptions from all associated GenBank mRNAs
  BC025318 - Homo sapiens kinesin light chain 3, mRNA (cDNA clone IMAGE:4310027), with apparent retained intron.
BC062998 - Homo sapiens kinesin light chain 3, mRNA (cDNA clone MGC:74597 IMAGE:5172274), complete cds.
JD125407 - Sequence 106431 from Patent EP1572962.
BC073841 - Homo sapiens kinesin light chain 3, mRNA (cDNA clone MGC:90195 IMAGE:5190809), complete cds.
JD454147 - Sequence 435171 from Patent EP1572962.
AK092481 - Homo sapiens cDNA FLJ35162 fis, clone PLACE6011881, highly similar to Rattus norvegicus kinesin light chain KLCt mRNA.
AX747564 - Sequence 1089 from Patent EP1308459.
BC126418 - Homo sapiens kinesin light chain 3, mRNA (cDNA clone MGC:161696 IMAGE:8992134), complete cds.
BC133037 - Homo sapiens kinesin light chain 3, mRNA (cDNA clone MGC:164668 IMAGE:40147059), complete cds.
HQ258275 - Synthetic construct Homo sapiens clone IMAGE:100072584 kinesin light chain 3 (KLC3) gene, encodes complete protein.
KJ900255 - Synthetic construct Homo sapiens clone ccsbBroadEn_09649 KLC3 gene, encodes complete protein.
KJ906433 - Synthetic construct Homo sapiens clone ccsbBroadEn_16103 KLC3 gene, encodes complete protein.
CU692968 - Synthetic construct Homo sapiens gateway clone IMAGE:100021812 5' read KLC3 mRNA.
KJ903847 - Synthetic construct Homo sapiens clone ccsbBroadEn_13241 KLC3 gene, encodes complete protein.
LF207546 - JP 2014500723-A/15049: Polycomb-Associated Non-Coding RNAs.
LF366981 - JP 2014500723-A/174484: Polycomb-Associated Non-Coding RNAs.
JD214355 - Sequence 195379 from Patent EP1572962.
JD356057 - Sequence 337081 from Patent EP1572962.
MA602558 - JP 2018138019-A/174484: Polycomb-Associated Non-Coding RNAs.
MA443123 - JP 2018138019-A/15049: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q6P597 (Reactome details) participates in the following event(s):

R-HSA-983194 Kinesin-1 is a heterotetramer
R-HSA-5672083 KTN1 binds Kinesin-1
R-HSA-983266 Kinesins bind microtubules
R-HSA-6811426 Retrograde COPI vesicles bind kinesin and microtubules
R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs
R-HSA-983189 Kinesins
R-HSA-5625970 RHO GTPases activate KTN1
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
R-HSA-195258 RHO GTPase Effectors
R-HSA-109582 Hemostasis
R-HSA-2132295 MHC class II antigen presentation
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-194315 Signaling by Rho GTPases
R-HSA-1280218 Adaptive Immune System
R-HSA-8856688 Golgi-to-ER retrograde transport
R-HSA-162582 Signal Transduction
R-HSA-168256 Immune System
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-199991 Membrane Trafficking
R-HSA-5653656 Vesicle-mediated transport

-  Other Names for This Gene
  Alternate Gene Symbols: A0AVM3, A2RUT6, ENST00000391946.1, ENST00000391946.2, ENST00000391946.3, ENST00000391946.4, ENST00000391946.5, ENST00000391946.6, KLC2, KLC2L, KLC3_HUMAN, NM_177417, Q6GMU2, Q6P597, Q8NAL1, Q8WWJ9, uc318usj.1, uc318usj.2
UCSC ID: ENST00000391946.7_8
RefSeq Accession: NM_177417.3
Protein: Q6P597 (aka KLC3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.