Human Gene KIR3DL1 (ENST00000391728.8_6) from GENCODE V47lift37

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Description: killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1 (from HGNC KIR3DL1)
Gencode Transcript: ENST00000391728.8_6
Gencode Gene: ENSG00000167633.18_9
Transcript (Including UTRs)
Position: hg19 chr19:55,327,923-55,342,233 Size: 14,311 Total Exon Count: 9 Strand: +
Coding Region
Position: hg19 chr19:55,327,956-55,341,730 Size: 13,775 Coding Exon Count: 9

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr19:55,327,923-55,342,233)			mRNA (may differ from genome)		Protein (444 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
Malacards	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: KIR3DL1 Diseases sorted by gene-association score: hiv-1* (960), birdshot chorioretinopathy (8), graft-versus-host disease, protection against (8), microscopic polyangiitis (8), hematopoietic stem cell transplantation (7), cytomegalovirus infection (5), hematologic cancer (3), behcet syndrome (1), sezary's disease (1) * = Manually curated disease association

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C009505 4,4'-diaminodiphenylmethane D000643 Ammonium Chloride D001151 Arsenic D001374 Azacitidine D015032 Zinc

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 2.68 RPKM in Whole Blood Total median expression: 4.48 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-11.60	33	-0.352	Picture	PostScript	Text
3' UTR	-112.70	503	-0.224	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub
IPR013151 - Immunoglobulin

Pfam Domains:
PF00047 - Immunoglobulin domain
PF13895 - Immunoglobulin domain

SCOP Domains:
48726 - Immunoglobulin

ModBase Predicted Comparative 3D Structure on Q5UCE2


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Cellular Component: GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	AF262973 - Homo sapiens killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1) mRNA, KIR3DL100701 allele, complete cds. U30274 - Human KIR (cl-11) NK receptor precursor protein mRNA, complete cds. AY366236 - Homo sapiens natural killer cell inhibitory receptor (KIR3DL1) mRNA, KIR3DL101502 allele, complete cds. AF262974 - Homo sapiens killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1) mRNA, KIR3DL100801 allele, complete cds. AY366253 - Homo sapiens natural killer cell inhibitory receptor (KIR3DL1/2V) mRNA, KIR3DL1/2Vc allele, complete cds. AY366255 - Homo sapiens natural killer cell inhibitory receptor (KIR3DL1/2V) mRNA, KIR3DL1/2Vd allele, complete cds. AY366254 - Homo sapiens natural killer cell inhibitory receptor (KIR3DL1/2V) mRNA, KIR3DL1/2Vb allele, complete cds. BC028206 - Homo sapiens killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1, mRNA (cDNA clone MGC:39948 IMAGE:5215674), complete cds. AY366250 - Homo sapiens natural killer cell inhibitory receptor (KIR3DL1) mRNA, KIR3DL1016 allele, complete cds. L41269 - Homo sapiens natural killer-associated transcript 3 (NKAT3), complete cds. AY789065 - Homo sapiens natural killer cell inhibitory receptor (KIR3DL1) mRNA, KIR3DL1007 allele, complete cds. BC101540 - Homo sapiens killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1, mRNA (cDNA clone MGC:126589 IMAGE:8069046), complete cds. BC101542 - Homo sapiens killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1, mRNA (cDNA clone MGC:126591 IMAGE:8069048), complete cds. U31416 - Homo sapiens killer cell Ig-like receptor (KIR3DL1) mRNA, complete cds. U33328 - Homo sapiens killer cell Ig-like receptor variant (KIR3DL1) mRNA, complete cds. BC143618 - Homo sapiens cDNA clone IMAGE:9052131. BC143616 - Homo sapiens cDNA clone IMAGE:9052129. L76664 - Homo sapiens nkat3-delta-Ig1 mRNA, complete cds. KJ904494 - Synthetic construct Homo sapiens clone ccsbBroadEn_13888 KIR2DS4-like gene, encodes complete protein. DQ891079 - Synthetic construct clone IMAGE:100003709; FLH169130.01X; RZPDo839G1094D killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 (KIR3DL1) gene, encodes complete protein. DQ894261 - Synthetic construct Homo sapiens clone IMAGE:100008721; FLH169126.01L; RZPDo839G1093D killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 (KIR3DL1) gene, encodes complete protein. AB590425 - Synthetic construct DNA, clone: pFN21AE2286, Homo sapiens KIR3DL1 gene for killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1, without stop codon, in Flexi system. U30273 - Human KIR (cl-2) NK receptor precursor protein mRNA, complete cds. KJ897095 - Synthetic construct Homo sapiens clone ccsbBroadEn_06489 KIR3DL1 gene, encodes complete protein. X94262 - H.sapiens mRNA for HLA-Bw4 specific inhibitory NK cell receptor. AY366252 - Homo sapiens natural killer cell inhibitory receptor (KIR3DL1) mRNA, KIR3DL1018 allele, partial cds. AF103010 - Homo sapiens JME clone 1 KIR3DL1-like natural killer cell receptor mRNA, complete cds. AF103011 - Homo sapiens JME clone 2 KIR3DL1-like natural killer cell receptor mRNA, complete cds. AF103012 - Homo sapiens JME clone 3 KIR3DL1-like natural killer cell receptor mRNA, complete cds. AF103013 - Homo sapiens JME clone 4 KIR3DL1-like natural killer cell receptor mRNA, complete cds. AY789066 - Homo sapiens natural killer cell inhibitory receptor (KIR3DL1) mRNA, KIR3DL1020 allele, complete cds. AY789072 - Homo sapiens natural killer cell inhibitory receptor (KIR3DL1) mRNA, KIR3DL1005 allele, complete cds. LS974087 - Homo sapiens mRNA for KIR3DL1 protein (KIR3DL1 gene), isolate 37, 39, allele Del294bp_(ex5)_hKIR3DL1_00501. LS974088 - Homo sapiens mRNA for KIR3DL1 protein (KIR3DL1 gene), isolate 85, allele Del594bp_(ex4+5)_hKIR3DL1. LS974100 - Homo sapiens mRNA for KIR3DL1 protein (KIR3DL1 gene), isolate 07, 72, allele Ins170bp_(3ss)_hKIR3DL1_019. LS974110 - Homo sapiens mRNA for KIR3DL1 protein (KIR3DL1 gene), isolate 72, 37, allele Del294_(3-5ss)_hKIR3DL1_00501. AF022049 - Homo sapiens natural killer cell inhibitory receptor KIR3DL1 variant mRNA, complete cds. AY760050 - Homo sapiens KIR3DL1 (KIR3DL1) mRNA, KIR3DL1-3DL1022 allele, complete cds. DQ178659 - Homo sapiens KIR3DL1 (KIR3DL1) mRNA, KIR3DL1-s24 allele, complete cds. AY366251 - Homo sapiens natural killer cell inhibitory receptor (KIR3DL1) mRNA, KIR3DL1017 allele, complete cds. AY366249 - Homo sapiens natural killer cell inhibitory receptor (KIR3DL1) mRNA, KIR3DL101501 allele, complete cds. AJ417556 - Homo sapiens partial mRNA for killer cell immunoglobulin receptor (KIR3DL1 gene), strain 3321. AJ417557 - Homo sapiens partial mRNA for killer cell immunoglobulin receptor (KIR3DL1 gene), strain 4053. AF208688 - Homo sapiens clone 3 p70 killer cell inhibitory receptor mRNA, partial cds. AF208689 - Homo sapiens clone 22 p70 killer cell inhibitory receptor mRNA, partial cds. AY059417 - Homo sapiens killer-cell immunoglobulin-like receptor KIR3DL1/2v mRNA, partial cds. EF462885 - Homo sapiens KIR3DL1 (KIR3DL1) mRNA, KIR3DL1-N5 allele, partial cds. EF472674 - Homo sapiens killer cell immunoglobulin-like receptor (KIR3DL1) mRNA, KIR3DL1N6 allele, partial cds. EF472675 - Homo sapiens killer cell immunoglobulin-like receptor (KIR3DL1) mRNA, KIR3DL1N7 allele, partial cds. EF472676 - Homo sapiens killer cell immunoglobulin-like receptor (KIR3DL1) mRNA, KIR3DL1N8 allele, partial cds. EF472677 - Homo sapiens killer cell immunoglobulin-like receptor (KIR3DL1) mRNA, KIR3DL1N9 allele, partial cds. EF472678 - Homo sapiens killer cell immunoglobulin-like receptor (KIR3DL1) mRNA, KIR3DL1N10 allele, partial cds. EF472679 - Homo sapiens killer cell immunoglobulin-like receptor (KIR3DL1) mRNA, KIR3DL1N11 allele, partial cds. AF262968 - Homo sapiens killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1) mRNA, KIR3DL100102 allele, partial cds. AF262969 - Homo sapiens killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1) mRNA, KIR3DL100401 allele, partial cds. AF262970 - Homo sapiens killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1) mRNA, KIR3DL100402 allele, partial cds. AF262971 - Homo sapiens killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1) mRNA, KIR3DL100501 allele, partial cds. AF262972 - Homo sapiens killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1) mRNA, KIR3DL1*00601 allele, partial cds. JD036258 - Sequence 17282 from Patent EP1572962. JD098050 - Sequence 79074 from Patent EP1572962. JD094365 - Sequence 75389 from Patent EP1572962. JD525272 - Sequence 506296 from Patent EP1572962. JD291661 - Sequence 272685 from Patent EP1572962. JD533385 - Sequence 514409 from Patent EP1572962. JD359368 - Sequence 340392 from Patent EP1572962. JD184336 - Sequence 165360 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A0A0C4ZLV3, ENST00000391728.1, ENST00000391728.2, ENST00000391728.3, ENST00000391728.4, ENST00000391728.5, ENST00000391728.6, ENST00000391728.7, KIR3DL1 , NM_013289, Q5UCE2, Q5UCE2_HUMAN, uc318unx.1, uc318unx.2 UCSC ID: ENST00000391728.8_6 Representative RNA: NM_013289 Protein: Q5UCE2

Gene Model Information


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Methods, Credits, and Use Restrictions


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