ID:KIF2B_HUMAN DESCRIPTION: RecName: Full=Kinesin-like protein KIF2B; FUNCTION: Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Association with kinetochore is transient. TISSUE SPECIFICITY: Highest level in lung. High level in ovary, moderate levels in heart, kidney, placenta, skeletal muscle and spleen (at protein level). Pancreas and spleen express a shorter isoform (at protein level). MISCELLANEOUS: Osteosarcoma cells (U2OS) lacking KIF2B show disorganised often monopolar mitotic spindles, severely reduced velocity of chromosome movement and blocked cytokinesis. Bipolar mitotic spindles can be restored by simultaneous depletion of KIF2B, KIFC1 and NUMA1. SIMILARITY: Belongs to the kinesin-like protein family. MCAK/KIF2 subfamily. SIMILARITY: Contains 1 kinesin-motor domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8N4N8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0007018 microtubule-based movement GO:0007019 microtubule depolymerization GO:0007049 cell cycle GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0051301 cell division GO:0051310 metaphase plate congression GO:0051983 regulation of chromosome segregation
HM005705 - Homo sapiens clone HTL-T-82P testis tissue sperm-binding protein Li 82P mRNA, complete cds. AK057272 - Homo sapiens cDNA FLJ32710 fis, clone TESTI2000699, moderately similar to KINESIN-LIKE PROTEIN KIF2. AF333335 - Homo sapiens kinesin mRNA, complete cds. JD197716 - Sequence 178740 from Patent EP1572962. JD452891 - Sequence 433915 from Patent EP1572962. BC033802 - Homo sapiens kinesin family member 2B, mRNA (cDNA clone MGC:44865 IMAGE:5170969), complete cds. JD147878 - Sequence 128902 from Patent EP1572962. AK302262 - Homo sapiens cDNA FLJ53902 complete cds, highly similar to Homo sapiens kinesin family member 2B (KIF2B), mRNA. AK308265 - Homo sapiens cDNA, FLJ98213. JD041512 - Sequence 22536 from Patent EP1572962. JD247291 - Sequence 228315 from Patent EP1572962. JD119630 - Sequence 100654 from Patent EP1572962. CU689754 - Synthetic construct Homo sapiens gateway clone IMAGE:100020003 5' read KIF2B mRNA. JF432265 - Synthetic construct Homo sapiens clone IMAGE:100073437 kinesin family member 2B (KIF2B) gene, encodes complete protein. KJ899816 - Synthetic construct Homo sapiens clone ccsbBroadEn_09210 KIF2B gene, encodes complete protein. JD067323 - Sequence 48347 from Patent EP1572962. JD362249 - Sequence 343273 from Patent EP1572962. JD156676 - Sequence 137700 from Patent EP1572962. JD092441 - Sequence 73465 from Patent EP1572962. JD559405 - Sequence 540429 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8N4N8 (Reactome details) participates in the following event(s):
R-HSA-141409 Mad1 binds kinetochore R-HSA-375302 Kinetochore capture of astral microtubules R-HSA-5666129 CDC42:GTP recruits DIAPH2-2 to kinetochores R-HSA-5666169 Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 R-HSA-990489 Kinesin-13 is a dimer R-HSA-141431 MAD2 associates with the Mad1 kinetochore complex R-HSA-141439 Release of activated MAD2 from kinetochores R-HSA-2467811 Separation of sister chromatids R-HSA-2467809 ESPL1 (Separase) cleaves centromeric cohesin R-HSA-5666160 AURKB phosphorylates DIAPH2-2 at kinetochores R-HSA-141422 MAD2 converted to an inhibitory state via interaction with Mad1 R-HSA-1638821 PP2A-B56 dephosphorylates centromeric cohesin R-HSA-1638803 Phosphorylation of cohesin by PLK1 at centromeres R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres R-HSA-983266 Kinesins bind microtubules R-HSA-6811426 Retrograde COPI vesicles bind kinesin and microtubules R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-68877 Mitotic Prometaphase R-HSA-5663220 RHO GTPases Activate Formins R-HSA-983189 Kinesins R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2467813 Separation of Sister Chromatids R-HSA-141424 Amplification of signal from the kinetochores R-HSA-68886 M Phase R-HSA-195258 RHO GTPase Effectors R-HSA-983231 Factors involved in megakaryocyte development and platelet production R-HSA-68882 Mitotic Anaphase R-HSA-69618 Mitotic Spindle Checkpoint R-HSA-69278 Cell Cycle (Mitotic) R-HSA-194315 Signaling by Rho GTPases R-HSA-109582 Hemostasis R-HSA-2555396 Mitotic Metaphase and Anaphase R-HSA-69620 Cell Cycle Checkpoints R-HSA-1640170 Cell Cycle R-HSA-162582 Signal Transduction R-HSA-2132295 MHC class II antigen presentation R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-HSA-1280218 Adaptive Immune System R-HSA-8856688 Golgi-to-ER retrograde transport R-HSA-168256 Immune System R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-199991 Membrane Trafficking R-HSA-5653656 Vesicle-mediated transport
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
