ID:KIF2A_HUMAN DESCRIPTION: RecName: Full=Kinesin-like protein KIF2A; AltName: Full=Kinesin-2; Short=hK2; FUNCTION: Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. SUBUNIT: Interacts with AURKA, PSRC1 and PLK1. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Note=Localized to the spindle microtubules and spindle poles from prophase to metaphase. Efficient targeting to spindle microtubules and spindle poles requires the kinase activity of PLK1. Recruited to mitotic spindles by interaction with PSRC1. MISCELLANEOUS: HeLa cells lacking KIF2A show asymmetric or monopolar mitotic spindles. Osteosarcoma cells (U2OS) lacking KIF2A or KIF2B show disorganised or monopolar mitotic spindles. SIMILARITY: Belongs to the kinesin-like protein family. MCAK/KIF2 subfamily. SIMILARITY: Contains 1 kinesin-motor domain. SEQUENCE CAUTION: Sequence=AAP84320.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O00139
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC047544 - Homo sapiens cDNA clone IMAGE:5298603, containing frame-shift errors. AK297347 - Homo sapiens cDNA FLJ56002 complete cds, highly similar to Kinesin-like protein KIF2. AK307880 - Homo sapiens cDNA, FLJ97828. EF560716 - Homo sapiens clone DKFZp781B0725 KIF2A protein (KIF2A) mRNA, complete cds. EF560728 - Homo sapiens clone DKFZp686D19248 KIF2A protein (KIF2A) mRNA, complete cds. EU832810 - Synthetic construct Homo sapiens clone HAIB:100067839; DKFZo008E0633 kinesin heavy chain member 2A protein (KIF2A) gene, encodes complete protein. GQ129246 - Synthetic construct Homo sapiens clone HAIB:100068500; DKFZo004E0634 kinesin heavy chain member 2A protein (KIF2A) gene, partial cds. AK315866 - Homo sapiens cDNA, FLJ79515 complete cds, highly similar to Kinesin-like protein KIF2. AK302270 - Homo sapiens cDNA FLJ55663 complete cds, highly similar to Kinesin-like protein KIF2. Y08319 - H.sapiens mRNA for kinesin-2. BC031828 - Homo sapiens kinesin heavy chain member 2A, mRNA (cDNA clone MGC:24890 IMAGE:4932771), complete cds. DQ894527 - Synthetic construct Homo sapiens clone IMAGE:100008987; FLH171275.01L; RZPDo839G0799D kinesin heavy chain member 2 (KIF2) gene, encodes complete protein. DQ891347 - Synthetic construct clone IMAGE:100003977; FLH171279.01X; RZPDo839G07100D kinesin heavy chain member 2 (KIF2) gene, encodes complete protein. CU689242 - Synthetic construct Homo sapiens gateway clone IMAGE:100018412 5' read KIF2A mRNA. AB590315 - Synthetic construct DNA, clone: pFN21AE0499, Homo sapiens KIF2A gene for kinesin heavy chain member 2A, without stop codon, in Flexi system. KJ901541 - Synthetic construct Homo sapiens clone ccsbBroadEn_10935 KIF2A gene, encodes complete protein. AY317140 - Homo sapiens kinesin heavy chain member 2 mRNA, complete cds. AY429552 - Homo sapiens KIF2 mRNA sequence; alternatively spliced. AK057153 - Homo sapiens cDNA FLJ32591 fis, clone SPLEN2000450, weakly similar to KINESIN-LIKE PROTEIN KIF2. JD043502 - Sequence 24526 from Patent EP1572962. JD390216 - Sequence 371240 from Patent EP1572962. JD206577 - Sequence 187601 from Patent EP1572962. JD473384 - Sequence 454408 from Patent EP1572962. JD083823 - Sequence 64847 from Patent EP1572962. JD386607 - Sequence 367631 from Patent EP1572962. JD372083 - Sequence 353107 from Patent EP1572962. JD292740 - Sequence 273764 from Patent EP1572962. JD527832 - Sequence 508856 from Patent EP1572962. JD470435 - Sequence 451459 from Patent EP1572962. JD300396 - Sequence 281420 from Patent EP1572962. JD220458 - Sequence 201482 from Patent EP1572962. JD545033 - Sequence 526057 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O00139 (Reactome details) participates in the following event(s):
R-HSA-141409 Mad1 binds kinetochore R-HSA-375302 Kinetochore capture of astral microtubules R-HSA-5666129 CDC42:GTP recruits DIAPH2-2 to kinetochores R-HSA-5666169 Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 R-HSA-990489 Kinesin-13 is a dimer R-HSA-141431 MAD2 associates with the Mad1 kinetochore complex R-HSA-141439 Release of activated MAD2 from kinetochores R-HSA-2467811 Separation of sister chromatids R-HSA-2467809 ESPL1 (Separase) cleaves centromeric cohesin R-HSA-5666160 AURKB phosphorylates DIAPH2-2 at kinetochores R-HSA-141422 MAD2 converted to an inhibitory state via interaction with Mad1 R-HSA-1638821 PP2A-B56 dephosphorylates centromeric cohesin R-HSA-1638803 Phosphorylation of cohesin by PLK1 at centromeres R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres R-HSA-983266 Kinesins bind microtubules R-HSA-6811426 Retrograde COPI vesicles bind kinesin and microtubules R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-68877 Mitotic Prometaphase R-HSA-5663220 RHO GTPases Activate Formins R-HSA-983189 Kinesins R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2467813 Separation of Sister Chromatids R-HSA-141424 Amplification of signal from the kinetochores R-HSA-68886 M Phase R-HSA-195258 RHO GTPase Effectors R-HSA-983231 Factors involved in megakaryocyte development and platelet production R-HSA-68882 Mitotic Anaphase R-HSA-69618 Mitotic Spindle Checkpoint R-HSA-69278 Cell Cycle (Mitotic) R-HSA-194315 Signaling by Rho GTPases R-HSA-109582 Hemostasis R-HSA-2555396 Mitotic Metaphase and Anaphase R-HSA-69620 Cell Cycle Checkpoints R-HSA-1640170 Cell Cycle R-HSA-162582 Signal Transduction R-HSA-2132295 MHC class II antigen presentation R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-HSA-1280218 Adaptive Immune System R-HSA-8856688 Golgi-to-ER retrograde transport R-HSA-168256 Immune System R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-199991 Membrane Trafficking R-HSA-5653656 Vesicle-mediated transport
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
