Human Gene KIF21B (ENST00000461742.7_12) from GENCODE V47lift37
  Description: kinesin family member 21B, transcript variant 3 (from RefSeq NM_001252102.2)
Gencode Transcript: ENST00000461742.7_12
Gencode Gene: ENSG00000116852.15_15
Transcript (Including UTRs)
   Position: hg19 chr1:200,938,518-200,992,842 Size: 54,325 Total Exon Count: 35 Strand: -
Coding Region
   Position: hg19 chr1:200,942,649-200,992,511 Size: 49,863 Coding Exon Count: 35 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:200,938,518-200,992,842)mRNA (may differ from genome)Protein (1623 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KI21B_HUMAN
DESCRIPTION: RecName: Full=Kinesin-like protein KIF21B;
FUNCTION: Microtubule-binding motor protein probably involved in neuronal dendritic transport. In vitro, has a plus-end directed motor activity (By similarity).
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity).
SIMILARITY: Belongs to the kinesin-like protein family.
SIMILARITY: Contains 1 kinesin-motor domain.
SIMILARITY: Contains 7 WD repeats.
SEQUENCE CAUTION: Sequence=BAA32294.2; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: KIF21B
Diseases sorted by gene-association score: tukel syndrome (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.90 RPKM in Brain - Cortex
Total median expression: 162.77 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -187.10331-0.565 Picture PostScript Text
3' UTR -1711.104131-0.414 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019821 - Kinesin_motor_CS
IPR001752 - Kinesin_motor_dom
IPR009053 - Prefoldin
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR019775 - WD40_repeat_CS
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF00225 - Kinesin motor domain
PF00400 - WD domain, G-beta repeat
PF16796 - Microtubule binding

SCOP Domains:
48371 - ARM repeat
46579 - Prefoldin
50952 - Soluble quinoprotein glucose dehydrogenase
50956 - Thermostable phytase (3-phytase)
50960 - TolB, C-terminal domain
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
117289 - Nucleoporin domain
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
50993 - Peptidase/esterase 'gauge' domain
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - DPP6 N-terminal domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on O75037
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0016887 ATPase activity

Biological Process:
GO:0007018 microtubule-based movement

Cellular Component:
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0031410 cytoplasmic vesicle
GO:0042995 cell projection


-  Descriptions from all associated GenBank mRNAs
  BC052964 - Homo sapiens kinesin family member 21B, mRNA (cDNA clone IMAGE:5768124).
AL137395 - Homo sapiens mRNA; cDNA DKFZp434J212 (from clone DKFZp434J212).
BC031927 - Homo sapiens kinesin family member 21B, mRNA (cDNA clone IMAGE:4938073), with apparent retained intron.
BC078676 - Homo sapiens kinesin family member 21B, mRNA (cDNA clone IMAGE:5141761).
AB007918 - Homo sapiens KIAA0449 mRNA for KIAA0449 protein.
JD087444 - Sequence 68468 from Patent EP1572962.
JD479665 - Sequence 460689 from Patent EP1572962.
JD154569 - Sequence 135593 from Patent EP1572962.
JD530788 - Sequence 511812 from Patent EP1572962.
JD548732 - Sequence 529756 from Patent EP1572962.
JD112708 - Sequence 93732 from Patent EP1572962.
JD524041 - Sequence 505065 from Patent EP1572962.
JD390347 - Sequence 371371 from Patent EP1572962.
JD181982 - Sequence 163006 from Patent EP1572962.
JD312716 - Sequence 293740 from Patent EP1572962.
JD184564 - Sequence 165588 from Patent EP1572962.
JD164189 - Sequence 145213 from Patent EP1572962.
JD114468 - Sequence 95492 from Patent EP1572962.
JD424506 - Sequence 405530 from Patent EP1572962.
JD452747 - Sequence 433771 from Patent EP1572962.
JD282996 - Sequence 264020 from Patent EP1572962.
JD393577 - Sequence 374601 from Patent EP1572962.
JD391765 - Sequence 372789 from Patent EP1572962.
JD063731 - Sequence 44755 from Patent EP1572962.
JD441051 - Sequence 422075 from Patent EP1572962.
JD204646 - Sequence 185670 from Patent EP1572962.
JD540942 - Sequence 521966 from Patent EP1572962.
JD090412 - Sequence 71436 from Patent EP1572962.
JD148478 - Sequence 129502 from Patent EP1572962.
JD289950 - Sequence 270974 from Patent EP1572962.
JD483910 - Sequence 464934 from Patent EP1572962.
JD192741 - Sequence 173765 from Patent EP1572962.
JD246281 - Sequence 227305 from Patent EP1572962.
JD544887 - Sequence 525911 from Patent EP1572962.
JD108667 - Sequence 89691 from Patent EP1572962.
JD162357 - Sequence 143381 from Patent EP1572962.
JD227313 - Sequence 208337 from Patent EP1572962.
JD370785 - Sequence 351809 from Patent EP1572962.
JD088236 - Sequence 69260 from Patent EP1572962.
JD560046 - Sequence 541070 from Patent EP1572962.
JD201676 - Sequence 182700 from Patent EP1572962.
JD070821 - Sequence 51845 from Patent EP1572962.
JD199719 - Sequence 180743 from Patent EP1572962.
JD295807 - Sequence 276831 from Patent EP1572962.
JD472328 - Sequence 453352 from Patent EP1572962.
JD452907 - Sequence 433931 from Patent EP1572962.
JD130035 - Sequence 111059 from Patent EP1572962.
JD381491 - Sequence 362515 from Patent EP1572962.
JD437732 - Sequence 418756 from Patent EP1572962.
DQ580244 - Homo sapiens piRNA piR-48356, complete sequence.
JD085718 - Sequence 66742 from Patent EP1572962.
JD450432 - Sequence 431456 from Patent EP1572962.
JD117687 - Sequence 98711 from Patent EP1572962.
JD231057 - Sequence 212081 from Patent EP1572962.
JD423074 - Sequence 404098 from Patent EP1572962.
JD448825 - Sequence 429849 from Patent EP1572962.
JD303421 - Sequence 284445 from Patent EP1572962.
JD387536 - Sequence 368560 from Patent EP1572962.
JD079890 - Sequence 60914 from Patent EP1572962.
JD211456 - Sequence 192480 from Patent EP1572962.
JD504655 - Sequence 485679 from Patent EP1572962.
JD477535 - Sequence 458559 from Patent EP1572962.
JD401150 - Sequence 382174 from Patent EP1572962.
JD271790 - Sequence 252814 from Patent EP1572962.
JD340285 - Sequence 321309 from Patent EP1572962.
JD394957 - Sequence 375981 from Patent EP1572962.
JD350421 - Sequence 331445 from Patent EP1572962.
JD496642 - Sequence 477666 from Patent EP1572962.
JD560350 - Sequence 541374 from Patent EP1572962.
BC144557 - Homo sapiens kinesin family member 21B, mRNA (cDNA clone MGC:178102 IMAGE:9053085), complete cds.
BC137281 - Homo sapiens kinesin family member 21B, mRNA (cDNA clone MGC:168901 IMAGE:9021278), complete cds.
JD233227 - Sequence 214251 from Patent EP1572962.
JD337118 - Sequence 318142 from Patent EP1572962.
KJ902270 - Synthetic construct Homo sapiens clone ccsbBroadEn_11664 KIF21B gene, encodes complete protein.
AM177180 - Homo sapiens mRNA for kinesin-like protein KIF21B variant (KIF21B gene).
AB527174 - Synthetic construct DNA, clone: pF1KA0449, Homo sapiens KIF21B gene for kinesin family member 21B, without stop codon, in Flexi system.
AK131318 - Homo sapiens cDNA FLJ16314 fis, clone SPLEN2030847.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O75037 (Reactome details) participates in the following event(s):

R-HSA-983266 Kinesins bind microtubules
R-HSA-6811426 Retrograde COPI vesicles bind kinesin and microtubules
R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs
R-HSA-983189 Kinesins
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
R-HSA-8856688 Golgi-to-ER retrograde transport
R-HSA-109582 Hemostasis
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-199991 Membrane Trafficking
R-HSA-5653656 Vesicle-mediated transport

-  Other Names for This Gene
  Alternate Gene Symbols: B2RP62, B7ZMI0, ENST00000461742.1, ENST00000461742.2, ENST00000461742.3, ENST00000461742.4, ENST00000461742.5, ENST00000461742.6, KI21B_HUMAN, KIAA0449, NM_001252102, O75037, Q5T4J3, uc321ddg.1, uc321ddg.2
UCSC ID: ENST00000461742.7_12
RefSeq Accession: NM_001252102.2
Protein: O75037 (aka KI21B_HUMAN or K21B_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.