ID:KI20B_HUMAN DESCRIPTION: RecName: Full=Kinesin-like protein KIF20B; AltName: Full=Cancer/testis antigen 90; Short=CT90; AltName: Full=Kinesin-related motor interacting with PIN1; AltName: Full=M-phase phosphoprotein 1; Short=MPP1; FUNCTION: Plus-end-directed motor enzyme that is required for completion of cytokinesis. SUBUNIT: Interacts with PIN1. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Localizes mainly in the nucleus during interphase although it is also detected in the cytoplasm without clear association with microtubules. A 2-3 fold expression increase is seen as cells progress from G1 to G2/M phase. During prophase and metaphase it is found throughout the cytoplasm and at anaphase accumulates at the midplan of the cell and forms a distinct band extending across the spindle midzone. At anaphase it is concentrated in the mid-body. TISSUE SPECIFICITY: Brain, ovary, kidney and testis. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the kinesin-like protein family. SIMILARITY: Contains 1 kinesin-motor domain. SEQUENCE CAUTION: Sequence=AAH46134.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAH58913.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAH93089.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAI08689.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAB15043.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=CAI12885.1; Type=Erroneous gene model prediction; Sequence=CAI16829.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96Q89
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001843 neural tube closure GO:0007018 microtubule-based movement GO:0007049 cell cycle GO:0007050 cell cycle arrest GO:0007088 regulation of mitotic nuclear division GO:0008284 positive regulation of cell proliferation GO:0032467 positive regulation of cytokinesis GO:0035372 protein localization to microtubule GO:0048812 neuron projection morphogenesis GO:0051301 cell division GO:0070201 regulation of establishment of protein localization GO:0090316 positive regulation of intracellular protein transport GO:1903438 positive regulation of mitotic cytokinetic process GO:2000114 regulation of establishment of cell polarity GO:2001222 regulation of neuron migration GO:2001224 positive regulation of neuron migration
AY282406 - Homo sapiens clone 1C12 M-phase phosphoprotein 1 (MPHOSPH1) mRNA, partial cds. AL117496 - Homo sapiens mRNA; cDNA DKFZp434B0435 (from clone DKFZp434B0435). AB033337 - Homo sapiens KRMP1 mRNA for mitotic kinesin-related protein, complete cds. BC042130 - Homo sapiens, Similar to M-phase phosphoprotein 1, clone IMAGE:4856992, mRNA. BC005221 - Homo sapiens M-phase phosphoprotein 1, mRNA (cDNA clone IMAGE:3685397), partial cds. AL137392 - Homo sapiens mRNA; cDNA DKFZp434I152 (from clone DKFZp434I152). AY282407 - Homo sapiens clone 1L9 M-phase phosphoprotein 1 (MPHOSPH1) mRNA, partial cds. AK290439 - Homo sapiens cDNA FLJ75531 partial cds. BC012585 - Homo sapiens cDNA clone IMAGE:4332982, containing frame-shift errors. BC108688 - Homo sapiens kinesin family member 20B, mRNA (cDNA clone IMAGE:3893085), partial cds. BC058913 - Homo sapiens kinesin family member 20B, mRNA (cDNA clone IMAGE:4536502), partial cds. BC093089 - Homo sapiens kinesin family member 20B, mRNA (cDNA clone IMAGE:30353122), partial cds. BC046134 - Homo sapiens kinesin family member 20B, mRNA (cDNA clone IMAGE:5786770), partial cds. AK074336 - Homo sapiens cDNA FLJ23756 fis, clone HEP17607, highly similar to M-phase phosphoprotein 1. AK024959 - Homo sapiens cDNA: FLJ21306 fis, clone COL02125. U93121 - Homo sapiens M-phase phosphoprotein-1 mRNA, partial cds. AY739715 - Homo sapiens M-phase phosphoprotein 1 (MPHOSPH1) mRNA, partial cds. L16782 - Human putative M phase phosphoprotein 1 (MPP1) mRNA, partial cds. AK025628 - Homo sapiens cDNA: FLJ21975 fis, clone HEP05866. JD274042 - Sequence 255066 from Patent EP1572962. JD244747 - Sequence 225771 from Patent EP1572962. JD093641 - Sequence 74665 from Patent EP1572962. JD197310 - Sequence 178334 from Patent EP1572962. JD491259 - Sequence 472283 from Patent EP1572962. JD492745 - Sequence 473769 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q96Q89 (Reactome details) participates in the following event(s):
R-HSA-983266 Kinesins bind microtubules R-HSA-6811426 Retrograde COPI vesicles bind kinesin and microtubules R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs R-HSA-983189 Kinesins R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-HSA-983231 Factors involved in megakaryocyte development and platelet production R-HSA-8856688 Golgi-to-ER retrograde transport R-HSA-109582 Hemostasis R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-199991 Membrane Trafficking R-HSA-5653656 Vesicle-mediated transport
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
