Human Gene KIF17 (ENST00000400463.8_8) from GENCODE V47lift37
  Description: kinesin family member 17, transcript variant 2 (from RefSeq NM_001122819.3)
Gencode Transcript: ENST00000400463.8_8
Gencode Gene: ENSG00000117245.13_12
Transcript (Including UTRs)
   Position: hg19 chr1:20,990,507-21,044,500 Size: 53,994 Total Exon Count: 15 Strand: -
Coding Region
   Position: hg19 chr1:20,991,077-21,044,199 Size: 53,123 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:20,990,507-21,044,500)mRNA (may differ from genome)Protein (1028 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KIF17_HUMAN
DESCRIPTION: RecName: Full=Kinesin-like protein KIF17; AltName: Full=KIF3-related motor protein;
FUNCTION: Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules (By similarity).
SUBUNIT: Interacts with LIN-10 PDZ domain. Interacts with PIWIL1 (By similarity). Interacts with TBATA (By similarity).
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (Probable).
SIMILARITY: Belongs to the kinesin-like protein family.
SIMILARITY: Contains 1 kinesin-motor domain.
SEQUENCE CAUTION: Sequence=AAD01428.1; Type=Frameshift; Positions=970, 990; Sequence=AAD01428.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part; Sequence=AAH36871.1; Type=Miscellaneous discrepancy; Note=Cloning artifact; Sequence=BAA92643.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part; Sequence=CAH73471.1; Type=Erroneous gene model prediction; Sequence=CAI23390.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: KIF17
Diseases sorted by gene-association score: sulfhemoglobinemia (10)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 30.64 RPKM in Testis
Total median expression: 110.23 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -181.10301-0.602 Picture PostScript Text
3' UTR -210.70570-0.370 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019821 - Kinesin_motor_CS
IPR001752 - Kinesin_motor_dom

Pfam Domains:
PF00225 - Kinesin motor domain
PF16796 - Microtubule binding

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q9P2E2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed

Biological Process:
GO:0007017 microtubule-based process
GO:0007018 microtubule-based movement
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0022008 neurogenesis
GO:0030030 cell projection organization
GO:0031503 protein complex localization
GO:0035735 intraciliary transport involved in cilium assembly
GO:0098971 anterograde dendritic transport of neurotransmitter receptor complex

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0005929 cilium
GO:0005930 axoneme
GO:0015630 microtubule cytoskeleton
GO:0030992 intraciliary transport particle B
GO:0032391 photoreceptor connecting cilium
GO:0032839 dendrite cytoplasm
GO:0036064 ciliary basal body
GO:0042995 cell projection
GO:1990075 periciliary membrane compartment


-  Descriptions from all associated GenBank mRNAs
  BC036871 - Homo sapiens, Similar to kinesin 17, clone IMAGE:5226131, mRNA, partial cds.
BC040639 - Homo sapiens kinesin family member 17, mRNA (cDNA clone IMAGE:5167979), containing frame-shift errors.
BC065927 - Homo sapiens kinesin family member 17, mRNA (cDNA clone MGC:70843 IMAGE:6171598), complete cds.
AB037826 - Homo sapiens KIAA1405 mRNA for KIAA1405 protein.
AB290162 - Homo sapiens mRNA for KIF17/KIAA1405 variant protein, complete cds.
AY484427 - Homo sapiens kinesin isoform KIF17B (KIF17B) mRNA, complete cds.
JD121002 - Sequence 102026 from Patent EP1572962.
JD220467 - Sequence 201491 from Patent EP1572962.
JD218908 - Sequence 199932 from Patent EP1572962.
JD326577 - Sequence 307601 from Patent EP1572962.
JD413240 - Sequence 394264 from Patent EP1572962.
JD550931 - Sequence 531955 from Patent EP1572962.
JD109394 - Sequence 90418 from Patent EP1572962.
JD464127 - Sequence 445151 from Patent EP1572962.
JD280939 - Sequence 261963 from Patent EP1572962.
AF009624 - Homo sapiens KIF3-related motor protein (KIF3X) mRNA, partial cds.
JD131708 - Sequence 112732 from Patent EP1572962.
JD445773 - Sequence 426797 from Patent EP1572962.
JD253920 - Sequence 234944 from Patent EP1572962.
JD330232 - Sequence 311256 from Patent EP1572962.
JD527936 - Sequence 508960 from Patent EP1572962.
JD193451 - Sequence 174475 from Patent EP1572962.
JD185263 - Sequence 166287 from Patent EP1572962.
AB463089 - Synthetic construct DNA, clone: pF1KA1405, Homo sapiens KIF17 gene for kinesin family member 17, without stop codon, in Flexi system.
JD520483 - Sequence 501507 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9P2E2 (Reactome details) participates in the following event(s):

R-HSA-5624951 TNPO1 binds KIF17 dimer
R-HSA-5625424 The retrograde IFT train dissociates
R-HSA-5624952 Assembly of the retrograde IFT train
R-HSA-5625421 The anterograde IFT train dissociates
R-HSA-5624949 Assembly of the anterograde IFT train
R-HSA-5620924 Intraflagellar transport
R-HSA-5617833 Cilium Assembly
R-HSA-1852241 Organelle biogenesis and maintenance

-  Other Names for This Gene
  Alternate Gene Symbols: A2A3Q7, A2A3Q8, ENST00000400463.1, ENST00000400463.2, ENST00000400463.3, ENST00000400463.4, ENST00000400463.5, ENST00000400463.6, ENST00000400463.7, KIAA1405, KIF17_HUMAN, KIF3X, NM_001122819, O95077, Q53YS6, Q5VWA9, Q6GSA8, Q8N411, Q9P2E2, uc319axe.1, uc319axe.2
UCSC ID: ENST00000400463.8_8
RefSeq Accession: NM_001122819.3
Protein: Q9P2E2 (aka KIF17_HUMAN or KF17_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.