ID:KIF15_HUMAN DESCRIPTION: RecName: Full=Kinesin-like protein KIF15; AltName: Full=Kinesin-like protein 2; Short=hKLP2; AltName: Full=Kinesin-like protein 7; AltName: Full=Serologically defined breast cancer antigen NY-BR-62; FUNCTION: Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly (By similarity). SUBUNIT: Interacts with MKI67 and TPX2. SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Detected during the interphase in the cytoplasm as finely punctuate pattern and irregularly shaped dots. Detected during mitosis on the mitotic spindle. Colocalizes with TPX2 in mitosis. Localizes at the central spindle at anaphase (By similarity). Localizes at the sites of invaginating cell membranes, a position that corresponds to the location of the contractile actomyosin ring of dividing cells (By similarity). Colocalizes with actin in interphase (By similarity). Colocalizes in dendrites and in growth cone of axons with microtubules (By similarity). TISSUE SPECIFICITY: Expressed in testis, colon, thymus and in breast cancer. SIMILARITY: Belongs to the kinesin-like protein family. KLP2 subfamily. SIMILARITY: Contains 1 kinesin-motor domain. SEQUENCE CAUTION: Sequence=AAG48261.1; Type=Frameshift; Positions=Several;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NS87
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000278 mitotic cell cycle GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0007018 microtubule-based movement GO:0008283 cell proliferation GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
