ID:KIF14_HUMAN DESCRIPTION: RecName: Full=Kinesin-like protein KIF14; FUNCTION: Plays an essential role in cytokinesis. SUBUNIT: Directly interacts with PRC1 within a complex also containing KIF4A, KIF20A and KIF23. Directly interacts with CIT depending on the activation state of the kinase (stronger interaction with the kinase-dead form). Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Nuclear localization observed during interphase in PubMed:16431929 or triggered by entry into mitosis in PubMed:16648480. Cytoplasmic in interphase (PubMed:16648480) and metaphase cells (PubMed:16431929). From prophase to metaphase, accumulates at the developing spindle poles and their associated microtubules. During anaphase, accumulates at the spindle midzone. Localization to the central spindle and midbody during anaphase is dependent upon PRC1 and CIT presence. In cells ready to undergo abscission, concentrates at the contractile ring. DEVELOPMENTAL STAGE: Up-regulated in cells progressing through G2/M phase. SIMILARITY: Belongs to the kinesin-like protein family. SIMILARITY: Contains 1 FHA domain. SIMILARITY: Contains 1 kinesin-motor domain. SEQUENCE CAUTION: Sequence=BAA05392.2; Type=Erroneous initiation; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/KIF14ID44138ch1q32.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15058
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001558 regulation of cell growth GO:0007018 microtubule-based movement GO:0007080 mitotic metaphase plate congression GO:0008284 positive regulation of cell proliferation GO:0010389 regulation of G2/M transition of mitotic cell cycle GO:0021685 cerebellar granular layer structural organization GO:0021693 cerebellar Purkinje cell layer structural organization GO:0021695 cerebellar cortex development GO:0021766 hippocampus development GO:0021772 olfactory bulb development GO:0021846 cell proliferation in forebrain GO:0021987 cerebral cortex development GO:0030155 regulation of cell adhesion GO:0030334 regulation of cell migration GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031641 regulation of myelination GO:0032147 activation of protein kinase activity GO:0032467 positive regulation of cytokinesis GO:0032487 regulation of Rap protein signal transduction GO:0033624 negative regulation of integrin activation GO:0034446 substrate adhesion-dependent cell spreading GO:0043066 negative regulation of apoptotic process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043523 regulation of neuron apoptotic process GO:0043524 negative regulation of neuron apoptotic process GO:0045184 establishment of protein localization GO:0051301 cell division GO:1903429 regulation of cell maturation GO:2000045 regulation of G1/S transition of mitotic cell cycle GO:0007019 microtubule depolymerization
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
