Human Gene KCNJ9 (ENST00000368088.4_4) from GENCODE V47lift37
  Description: potassium inwardly rectifying channel subfamily J member 9 (from RefSeq NM_004983.3)
Gencode Transcript: ENST00000368088.4_4
Gencode Gene: ENSG00000162728.5_7
Transcript (Including UTRs)
   Position: hg19 chr1:160,051,328-160,060,353 Size: 9,026 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr1:160,053,821-160,057,607 Size: 3,787 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:160,051,328-160,060,353)mRNA (may differ from genome)Protein (393 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: IRK9_HUMAN
DESCRIPTION: RecName: Full=G protein-activated inward rectifier potassium channel 3; Short=GIRK-3; AltName: Full=Inward rectifier K(+) channel Kir3.3; AltName: Full=Potassium channel, inwardly rectifying subfamily J member 9;
FUNCTION: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (By similarity).
SUBUNIT: Associates with GIRK1 to form a G-protein-activated heteromultimer pore-forming unit (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ9 subfamily.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: KCNJ9
Diseases sorted by gene-association score: corneal dystrophy, schnyder type (8)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 66.70 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 423.99 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -130.60274-0.477 Picture PostScript Text
3' UTR -1007.002746-0.367 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR014756 - Ig_E-set
IPR016449 - K_chnl_inward-rec_Kir
IPR003276 - K_chnl_inward-rec_Kir3.3
IPR013518 - K_chnl_inward-rec_Kir_cyto

Pfam Domains:
PF01007 - Inward rectifier potassium channel transmembrane domain
PF17655 - Inward rectifier potassium channel C-terminal domain

SCOP Domains:
81296 - E set domains
81324 - Voltage-gated potassium channels

ModBase Predicted Comparative 3D Structure on Q92806
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005242 inward rectifier potassium channel activity
GO:0005244 voltage-gated ion channel activity
GO:0005515 protein binding
GO:0015467 G-protein activated inward rectifier potassium channel activity

Biological Process:
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0010107 potassium ion import
GO:0034765 regulation of ion transmembrane transport

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  U52152 - Human inwardly rectifying potassium channel Kir3.3 mRNA, complete cds.
BC117516 - Homo sapiens cDNA clone IMAGE:40010261.
BC117517 - Homo sapiens cDNA clone IMAGE:40010263.
BC117518 - Homo sapiens cDNA clone IMAGE:40010266.
BC117519 - Homo sapiens cDNA clone IMAGE:40010267.
JD118125 - Sequence 99149 from Patent EP1572962.
AB385053 - Synthetic construct DNA, clone: pF1KB5140, Homo sapiens KCNJ9 gene for G protein-activated inward rectifier potassium channel 3, complete cds, without stop codon, in Flexi system.
BC167777 - Synthetic construct Homo sapiens clone IMAGE:100068167, MGC:195784 potassium inwardly-rectifying channel, subfamily J, member 9 (KCNJ9) mRNA, encodes complete protein.
LF205470 - JP 2014500723-A/12973: Polycomb-Associated Non-Coding RNAs.
JD497022 - Sequence 478046 from Patent EP1572962.
JD435635 - Sequence 416659 from Patent EP1572962.
JD256391 - Sequence 237415 from Patent EP1572962.
JD205939 - Sequence 186963 from Patent EP1572962.
JD446817 - Sequence 427841 from Patent EP1572962.
JD222587 - Sequence 203611 from Patent EP1572962.
JD362620 - Sequence 343644 from Patent EP1572962.
JD375496 - Sequence 356520 from Patent EP1572962.
JD253132 - Sequence 234156 from Patent EP1572962.
JD044349 - Sequence 25373 from Patent EP1572962.
JD446140 - Sequence 427164 from Patent EP1572962.
JD211675 - Sequence 192699 from Patent EP1572962.
JD214526 - Sequence 195550 from Patent EP1572962.
JD068619 - Sequence 49643 from Patent EP1572962.
JD186327 - Sequence 167351 from Patent EP1572962.
JD230644 - Sequence 211668 from Patent EP1572962.
JD217161 - Sequence 198185 from Patent EP1572962.
JD527095 - Sequence 508119 from Patent EP1572962.
JD278794 - Sequence 259818 from Patent EP1572962.
JD343759 - Sequence 324783 from Patent EP1572962.
JD343151 - Sequence 324175 from Patent EP1572962.
JD403411 - Sequence 384435 from Patent EP1572962.
JD184091 - Sequence 165115 from Patent EP1572962.
JD113220 - Sequence 94244 from Patent EP1572962.
JD231478 - Sequence 212502 from Patent EP1572962.
JD544931 - Sequence 525955 from Patent EP1572962.
JD221268 - Sequence 202292 from Patent EP1572962.
JD310808 - Sequence 291832 from Patent EP1572962.
JD176893 - Sequence 157917 from Patent EP1572962.
JD054981 - Sequence 36005 from Patent EP1572962.
JD127479 - Sequence 108503 from Patent EP1572962.
MA441047 - JP 2018138019-A/12973: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q92806 (Reactome details) participates in the following event(s):

R-HSA-1013020 Activation of GIRK/Kir3 Channels
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
R-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-991365 Activation of GABAB receptors
R-HSA-1296059 G protein gated Potassium channels
R-HSA-977444 GABA B receptor activation
R-HSA-1296065 Inwardly rectifying K+ channels
R-HSA-977443 GABA receptor activation
R-HSA-1296071 Potassium Channels
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112316 Neuronal System
R-HSA-112315 Transmission across Chemical Synapses

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000368088.1, ENST00000368088.2, ENST00000368088.3, GIRK3, KCNJ9_HUMAN, NM_004983, Q5JW75, Q92806, uc318glq.1, uc318glq.2
UCSC ID: ENST00000368088.4_4
RefSeq Accession: NM_004983.3
Protein: Q92806 (aka IRK9_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.