ID:KCNA4_HUMAN DESCRIPTION: RecName: Full=Potassium voltage-gated channel subfamily A member 4; AltName: Full=HPCN2; AltName: Full=Voltage-gated K(+) channel HuKII; AltName: Full=Voltage-gated potassium channel HBK4; AltName: Full=Voltage-gated potassium channel HK1; AltName: Full=Voltage-gated potassium channel subunit Kv1.4; FUNCTION: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. SUBUNIT: Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4. Interacts with SIGMAR1 (By similarity). Part of a complex containing KCNA1, KCNAB1 and LGI1 (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. DOMAIN: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. DOMAIN: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. SIMILARITY: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00520 - Ion transport protein PF02214 - BTB/POZ domain PF07885 - Ion channel PF07941 - Potassium channel Kv1.4 tandem inactivation domain
ModBase Predicted Comparative 3D Structure on P22459
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005216 ion channel activity GO:0005244 voltage-gated ion channel activity GO:0005249 voltage-gated potassium channel activity GO:0005267 potassium channel activity GO:0005515 protein binding GO:0030955 potassium ion binding
Biological Process: GO:0006811 ion transport GO:0006813 potassium ion transport GO:0034765 regulation of ion transmembrane transport GO:0051260 protein homooligomerization GO:0055085 transmembrane transport GO:0071805 potassium ion transmembrane transport
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
