ID:KAT6A_HUMAN DESCRIPTION: RecName: Full=Histone acetyltransferase KAT6A; EC=2.3.1.48; AltName: Full=MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3; Short=MYST-3; AltName: Full=Monocytic leukemia zinc finger protein; AltName: Full=Runt-related transcription factor-binding protein 2; AltName: Full=Zinc finger protein 220; FUNCTION: Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. CATALYTIC ACTIVITY: Acetyl-CoA + [histone] = CoA + acetyl- [histone]. SUBUNIT: Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. Interacts with RUNX1; phosphorylation of RUNX1 enhances the interaction. Interacts with RUNX2. INTERACTION: Q03164:MLL; NbExp=10; IntAct=EBI-948013, EBI-2638616; P61964:WDR5; NbExp=4; IntAct=EBI-948013, EBI-540834; SUBCELLULAR LOCATION: Nucleus. Note=Partially concentrated in subnuclear foci distinct from PML bodies, and excluded from the nucleoli. DOMAIN: The N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional repression. PTM: Autoacetylated. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. PTM: Autoacetylation at Lys-604 is required for proper function (By similarity). DISEASE: Note=Chromosomal aberrations involving KAT6A may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with CREBBP; translocation t(8;22)(p11;q13) with EP300. KAT6A- CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation. DISEASE: Note=A chromosomal aberration involving KAT6A is a cause of therapy-related myelodysplastic syndrome. Translocation t(2;8)(p23;p11.2) with ASXL2 generates a KAT6A-ASXL2 fusion protein. SIMILARITY: Belongs to the MYST (SAS/MOZ) family. SIMILARITY: Contains 1 C2HC-type zinc finger. SIMILARITY: Contains 1 H15 (linker histone H1/H5 globular) domain. SIMILARITY: Contains 2 PHD-type zinc fingers. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/MYST3ID25ch8p11.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q92794
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
