ID:KANK2_HUMAN DESCRIPTION: RecName: Full=KN motif and ankyrin repeat domain-containing protein 2; AltName: Full=Ankyrin repeat domain-containing protein 25; AltName: Full=Matrix-remodeling-associated protein 3; AltName: Full=SRC-1-interacting protein; Short=SIP; Short=SRC-interacting protein; Short=SRC1-interacting protein; FUNCTION: Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase- independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus. May be involved in promotion of cell proliferation. SUBUNIT: Interacts (phosphorylated) with NCOA1; NCOA2 AND NCOA3. Interacts with AIFM1. INTERACTION: O95831:AIFM1; NbExp=4; IntAct=EBI-6244894, EBI-356440; SUBCELLULAR LOCATION: Cytoplasm. Mitochondrion. TISSUE SPECIFICITY: Strongly expressed in cervix, colon, heart, kidney and lung. Expressed in kidney glomerular podocytes and mesangial cells (at protein level). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated by CaMK2 upon estrogen stimulation. SIMILARITY: Contains 5 ANK repeats. SEQUENCE CAUTION: Sequence=BAA92081.1; Type=Erroneous initiation; Sequence=BAA96042.2; Type=Erroneous initiation; Sequence=BAB14531.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q63ZY3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006915 apoptotic process GO:0008285 negative regulation of cell proliferation GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway GO:0043069 negative regulation of programmed cell death GO:0070563 negative regulation of vitamin D receptor signaling pathway GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
