Human Gene IVD (ENST00000487418.8_8) from GENCODE V47lift37
  Description: isovaleryl-CoA dehydrogenase, transcript variant 1 (from RefSeq NM_002225.5)
Gencode Transcript: ENST00000487418.8_8
Gencode Gene: ENSG00000128928.10_15
Transcript (Including UTRs)
   Position: hg19 chr15:40,697,996-40,713,507 Size: 15,512 Total Exon Count: 12 Strand: +
Coding Region
   Position: hg19 chr15:40,698,029-40,710,462 Size: 12,434 Coding Exon Count: 12 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathways
Other NamesGeneReviewsModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:40,697,996-40,713,507)mRNA (may differ from genome)Protein (423 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: IVD
Diseases sorted by gene-association score: isovaleric acidemia* (1711), bone deterioration disease (19), bone structure disease (19), acute endophthalmitis (15), discitis (9), purulent endophthalmitis (9), polyradiculopathy (7), boomerang dysplasia (7), strongyloidiasis (6), degenerative disc disease (6), spondylolisthesis (6), amphetamine abuse (6), atelosteogenesis (5)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 62.75 RPKM in Thyroid
Total median expression: 773.91 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -4.9033-0.148 Picture PostScript Text
3' UTR -1104.003045-0.363 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGD    
      
      

-  Descriptions from all associated GenBank mRNAs
  AK122922 - Homo sapiens cDNA FLJ16602 fis, clone TESTI4007816, highly similar to Isovaleryl-CoA dehydrogenase, mitochondrial precursor (EC 1.3.99.10).
M34192 - Human isovaleryl-coA dehydrogenase (IVD) mRNA, complete cds.
BC017202 - Homo sapiens isovaleryl Coenzyme A dehydrogenase, mRNA (cDNA clone MGC:3496 IMAGE:3627787), complete cds.
GQ901004 - Homo sapiens clone HEL-T-116 epididymis secretory sperm binding protein mRNA, complete cds.
AK315296 - Homo sapiens cDNA, FLJ96315, Homo sapiens isovaleryl Coenzyme A dehydrogenase (IVD), nucleargene encoding mitochondrial protein, mRNA.
KJ901040 - Synthetic construct Homo sapiens clone ccsbBroadEn_10434 IVD gene, encodes complete protein.
KR710290 - Synthetic construct Homo sapiens clone CCSBHm_00011081 IVD (IVD) mRNA, encodes complete protein.
KR710291 - Synthetic construct Homo sapiens clone CCSBHm_00011098 IVD (IVD) mRNA, encodes complete protein.
KR710292 - Synthetic construct Homo sapiens clone CCSBHm_00011101 IVD (IVD) mRNA, encodes complete protein.
KU178150 - Homo sapiens isovaleryl-CoA dehydrogenase isoform 1 (IVD) mRNA, partial cds.
KU178151 - Homo sapiens isovaleryl-CoA dehydrogenase isoform 2 (IVD) mRNA, partial cds.
KU178152 - Homo sapiens isovaleryl-CoA dehydrogenase isoform 3 (IVD) mRNA, complete cds, alternatively spliced.
DQ895793 - Synthetic construct Homo sapiens clone IMAGE:100010253; FLH187699.01L; RZPDo839C03149D isovaleryl Coenzyme A dehydrogenase (IVD) gene, encodes complete protein.
BT007145 - Homo sapiens isovaleryl Coenzyme A dehydrogenase mRNA, complete cds.
DQ892577 - Synthetic construct clone IMAGE:100005207; FLH187703.01X; RZPDo839C03150D isovaleryl Coenzyme A dehydrogenase (IVD) gene, encodes complete protein.
DQ591778 - Homo sapiens piRNA piR-58890, complete sequence.
AK092168 - Homo sapiens cDNA FLJ34849 fis, clone NT2NE2011687.
AF070531 - Homo sapiens clone 24764 mRNA sequence.
AK022777 - Homo sapiens cDNA FLJ12715 fis, clone NT2RP1001185, highly similar to Human isovaleryl-coA dehydrogenase (IVD) mRNA.
JD055737 - Sequence 36761 from Patent EP1572962.
JD453017 - Sequence 434041 from Patent EP1572962.
JD398867 - Sequence 379891 from Patent EP1572962.
JD355108 - Sequence 336132 from Patent EP1572962.
JD490477 - Sequence 471501 from Patent EP1572962.
JD271193 - Sequence 252217 from Patent EP1572962.
JD484520 - Sequence 465544 from Patent EP1572962.
JD535928 - Sequence 516952 from Patent EP1572962.
JD237504 - Sequence 218528 from Patent EP1572962.
JD133620 - Sequence 114644 from Patent EP1572962.
JD420943 - Sequence 401967 from Patent EP1572962.
AY826821 - Homo sapiens cell growth-inhibiting protein 48a mRNA, complete cds.
AY826822 - Homo sapiens cell growth-inhibiting protein 48b mRNA, complete cds.
AY826823 - Homo sapiens cell growth-inhibiting protein 48c mRNA, complete cds.
JD514945 - Sequence 495969 from Patent EP1572962.
JD294137 - Sequence 275161 from Patent EP1572962.
JD421512 - Sequence 402536 from Patent EP1572962.
JD179115 - Sequence 160139 from Patent EP1572962.
JD179116 - Sequence 160140 from Patent EP1572962.
JD169296 - Sequence 150320 from Patent EP1572962.
JD321065 - Sequence 302089 from Patent EP1572962.
JD388222 - Sequence 369246 from Patent EP1572962.
JD118365 - Sequence 99389 from Patent EP1572962.
JD146094 - Sequence 127118 from Patent EP1572962.
JD551655 - Sequence 532679 from Patent EP1572962.
JD507305 - Sequence 488329 from Patent EP1572962.
JD144717 - Sequence 125741 from Patent EP1572962.
BC037304 - Homo sapiens cDNA clone IMAGE:5264866.
JD451181 - Sequence 432205 from Patent EP1572962.
DQ596676 - Homo sapiens piRNA piR-34742, complete sequence.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
LEU-DEG2-PWY - L-leucine degradation

-  Other Names for This Gene
  Alternate Gene Symbols: A0A0A0MT83, A0A0A0MT83_HUMAN, A0A0S2Z422, ENST00000487418.1, ENST00000487418.2, ENST00000487418.3, ENST00000487418.4, ENST00000487418.5, ENST00000487418.6, ENST00000487418.7, IVD , NM_002225, uc322hpt.1, uc322hpt.2
UCSC ID: ENST00000487418.8_8
RefSeq Accession: NM_002225.5

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene IVD:
isovaleric-a (Classic Isovaleric Acidemia)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.