Human Gene ITPRIP (ENST00000337478.3_7) from GENCODE V47lift37

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Description: inositol 1,4,5-trisphosphate receptor interacting protein, transcript variant 3 (from RefSeq NM_001272013.2)
Gencode Transcript: ENST00000337478.3_7
Gencode Gene: ENSG00000148841.17_11
Transcript (Including UTRs)
Position: hg19 chr10:106,069,458-106,098,223 Size: 28,766 Total Exon Count: 2 Strand: -
Coding Region
Position: hg19 chr10:106,074,166-106,075,809 Size: 1,644 Coding Exon Count: 1

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr10:106,069,458-106,098,223)			mRNA (may differ from genome)		Protein (547 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: IPRI_HUMAN DESCRIPTION: RecName: Full=Inositol 1,4,5-trisphosphate receptor-interacting protein; AltName: Full=Protein DANGER; Flags: Precursor; FUNCTION: Enhances Ca(2+)-mediated inhibition of inositol 1,4,5- triphosphate receptor (ITPR) Ca(2+) release. SUBUNIT: Interacts with ITPR. SUBCELLULAR LOCATION: Cell membrane. TISSUE SPECIFICITY: Detected in brain where it is concentrated in cerebellar Purkinje cells (at protein level). SIMILARITY: Belongs to the ITPRIP family. SEQUENCE CAUTION: Sequence=BAB21845.1; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C006780 bisphenol A D016604 Aflatoxin B1 D019327 Copper Sulfate D016572 Cyclosporine D003993 Dibutyl Phthalate D004958 Estradiol C568608 PCI 5002 D011794 Quercetin D013749 Tetrachlorodibenzodioxin D015032 Zinc more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 41.38 RPKM in Skin - Sun Exposed (Lower leg) Total median expression: 621.11 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-97.10	233	-0.417	Picture	PostScript	Text
3' UTR	-1630.30	4708	-0.346	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR026250 - INOS145TPRIP
IPR024797 - IP3R-int
IPR020950 - Mab-21-rel
IPR024810 - Mab-21_dom

Pfam Domains:
PF03281 - Mab-21 protein

ModBase Predicted Comparative 3D Structure on Q8IWB1


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding Cellular Component: GO:0005886 plasma membrane GO:0016020 membrane

Descriptions from all associated GenBank mRNAs


	AK094802 - Homo sapiens cDNA FLJ37483 fis, clone BRAWH2014188. AB051541 - Homo sapiens KIAA1754 mRNA for KIAA1754 protein. BC040536 - Homo sapiens inositol 1,4,5-triphosphate receptor interacting protein, mRNA (cDNA clone MGC:39629 IMAGE:5265379), complete cds. BC070108 - Homo sapiens inositol 1,4,5-triphosphate receptor interacting protein, mRNA (cDNA clone MGC:87628 IMAGE:4837204), complete cds. AK056526 - Homo sapiens cDNA FLJ31964 fis, clone NT2RP7007617. AY189283 - Homo sapiens LP5085 protein mRNA, complete cds. AK055608 - Homo sapiens cDNA FLJ31046 fis, clone HSYRA2000347. JD260631 - Sequence 241655 from Patent EP1572962. JD206959 - Sequence 187983 from Patent EP1572962. JD069650 - Sequence 50674 from Patent EP1572962. JD378310 - Sequence 359334 from Patent EP1572962. AY358776 - Homo sapiens clone DNA69555 GTWW5826 (UNQ5826) mRNA, complete cds. JD053430 - Sequence 34454 from Patent EP1572962. JD078145 - Sequence 59169 from Patent EP1572962. JD053592 - Sequence 34616 from Patent EP1572962. AK129877 - Homo sapiens cDNA FLJ26367 fis, clone HRT05864. JD239909 - Sequence 220933 from Patent EP1572962. JD109433 - Sequence 90457 from Patent EP1572962. JD499190 - Sequence 480214 from Patent EP1572962. JD050484 - Sequence 31508 from Patent EP1572962. JD199095 - Sequence 180119 from Patent EP1572962. JD413792 - Sequence 394816 from Patent EP1572962. DQ594145 - Homo sapiens piRNA piR-60257, complete sequence. JD345418 - Sequence 326442 from Patent EP1572962. JD511283 - Sequence 492307 from Patent EP1572962. JD537837 - Sequence 518861 from Patent EP1572962. JD064948 - Sequence 45972 from Patent EP1572962. JD134250 - Sequence 115274 from Patent EP1572962. JD361876 - Sequence 342900 from Patent EP1572962. JD157852 - Sequence 138876 from Patent EP1572962. JD196727 - Sequence 177751 from Patent EP1572962. JD553535 - Sequence 534559 from Patent EP1572962. JD544965 - Sequence 525989 from Patent EP1572962. JD110351 - Sequence 91375 from Patent EP1572962. JD512876 - Sequence 493900 from Patent EP1572962. JD067693 - Sequence 48717 from Patent EP1572962. JD108246 - Sequence 89270 from Patent EP1572962. JD310973 - Sequence 291997 from Patent EP1572962. JD156954 - Sequence 137978 from Patent EP1572962. JD414389 - Sequence 395413 from Patent EP1572962. JD103191 - Sequence 84215 from Patent EP1572962. AB384287 - Synthetic construct DNA, clone: pF1KSDA1754, Homo sapiens KIAA1754 gene for KIAA1754 protein, complete cds, without stop codon, in Flexi system. KJ904934 - Synthetic construct Homo sapiens clone ccsbBroadEn_14328 ITPRIP gene, encodes complete protein.

Other Names for This Gene


	Alternate Gene Symbols: D3DRA5, DANGER, ENST00000337478.1, ENST00000337478.2, IPRI_HUMAN, KIAA1754, NM_001272013, Q5JU17, Q8IWB1, Q96MS8, Q9C0A9, uc317utw.1, uc317utw.2 UCSC ID: ENST00000337478.3_7 RefSeq Accession: NM_001272013.2 Protein: Q8IWB1 (aka IPRI_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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