ID:ITIH4_HUMAN DESCRIPTION: RecName: Full=Inter-alpha-trypsin inhibitor heavy chain H4; Short=ITI heavy chain H4; Short=ITI-HC4; Short=Inter-alpha-inhibitor heavy chain 4; AltName: Full=Inter-alpha-trypsin inhibitor family heavy chain-related protein; Short=IHRP; AltName: Full=Plasma kallikrein sensitive glycoprotein 120; Short=Gp120; Short=PK-120; Contains: RecName: Full=70 kDa inter-alpha-trypsin inhibitor heavy chain H4; Contains: RecName: Full=35 kDa inter-alpha-trypsin inhibitor heavy chain H4; Flags: Precursor; FUNCTION: May be involved in acute phase reactions. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Liver specific. INDUCTION: Levels increase significantly in the sera of patients after different surgical trauma. PTM: Cleaved by plasma kallikrein to yield 100 kDa and 35 kDa fragments, and the resulting 100 kDa fragment is further converted to a 70 kDa fragment. PTM: Appears to be both N- and O-glycosylated. The O-linked polysaccharides on Ser-696, Thr-701 and Ser-702 are probably the mucin type linked to GalNAc. O-linked glycosylations in the region AA 719-725 consist of core 1 or possibly core 8 glycans. SIMILARITY: Belongs to the ITIH family. SIMILARITY: Contains 1 VIT domain. SIMILARITY: Contains 1 VWFA domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00092 - von Willebrand factor type A domain PF06668 - Inter-alpha-trypsin inhibitor heavy chain C-terminus PF08487 - Vault protein inter-alpha-trypsin domain PF13519 - von Willebrand factor type A domain PF13768 - von Willebrand factor type A domain
ModBase Predicted Comparative 3D Structure on Q14624
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
