ID:ITAM_HUMAN DESCRIPTION: RecName: Full=Integrin alpha-M; AltName: Full=CD11 antigen-like family member B; AltName: Full=CR-3 alpha chain; AltName: Full=Cell surface glycoprotein MAC-1 subunit alpha; AltName: Full=Leukocyte adhesion receptor MO1; AltName: Full=Neutrophil adherence receptor; AltName: CD_antigen=CD11b; Flags: Precursor; FUNCTION: Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Interacts with JAM3. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Predominantly expressed in monocytes and granulocytes. DOMAIN: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. DISEASE: Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. SIMILARITY: Belongs to the integrin alpha chain family. SIMILARITY: Contains 7 FG-GAP repeats. SIMILARITY: Contains 1 VWFA domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00092 - von Willebrand factor type A domain PF00357 - Integrin alpha cytoplasmic region PF01839 - FG-GAP repeat PF08441 - Integrin alpha PF13519 - von Willebrand factor type A domain
ModBase Predicted Comparative 3D Structure on P11215
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0001851 complement component C3b binding GO:0005515 protein binding GO:0031072 heat shock protein binding GO:0046872 metal ion binding GO:0046982 protein heterodimerization activity
Biological Process: GO:0001774 microglial cell activation GO:0002376 immune system process GO:0006911 phagocytosis, engulfment GO:0007155 cell adhesion GO:0007229 integrin-mediated signaling pathway GO:0010668 ectodermal cell differentiation GO:0019221 cytokine-mediated signaling pathway GO:0030198 extracellular matrix organization GO:0032930 positive regulation of superoxide anion generation GO:0034142 toll-like receptor 4 signaling pathway GO:0043312 neutrophil degranulation GO:0043315 positive regulation of neutrophil degranulation GO:0045087 innate immune response GO:0045963 negative regulation of dopamine metabolic process GO:0050900 leukocyte migration GO:0090314 positive regulation of protein targeting to membrane GO:0097242 beta-amyloid clearance GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules GO:1901216 positive regulation of neuron death GO:1903980 positive regulation of microglial cell activation GO:2000363 positive regulation of prostaglandin-E synthase activity
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
