ID:ISY1_HUMAN DESCRIPTION: RecName: Full=Pre-mRNA-splicing factor ISY1 homolog; FUNCTION: May play a role in pre-mRNA splicing (Potential). SUBUNIT: Identified in the spliceosome C complex. SUBCELLULAR LOCATION: Nucleus (Potential). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the ISY1 family. SEQUENCE CAUTION: Sequence=BAA86474.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9ULR0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AB032986 - Homo sapiens KIAA1160 mRNA for KIAA1160 protein. AB384574 - Synthetic construct DNA, clone: pF1KA1160, Homo sapiens ISY1 gene for pre-mRNA-splicing factor ISY1 homolog, complete cds, without stop codon, in Flexi system. AK024035 - Homo sapiens cDNA FLJ13973 fis, clone Y79AA1001555. JD468922 - Sequence 449946 from Patent EP1572962. JD388662 - Sequence 369686 from Patent EP1572962. JD068746 - Sequence 49770 from Patent EP1572962. JD368860 - Sequence 349884 from Patent EP1572962. JD439819 - Sequence 420843 from Patent EP1572962. JD474980 - Sequence 456004 from Patent EP1572962. JD280540 - Sequence 261564 from Patent EP1572962. JD344121 - Sequence 325145 from Patent EP1572962. JD388440 - Sequence 369464 from Patent EP1572962. JD438203 - Sequence 419227 from Patent EP1572962. DQ579703 - Homo sapiens piRNA piR-47815, complete sequence. BC018848 - Homo sapiens cDNA clone IMAGE:3141182, **** WARNING: chimeric clone ****. BC004122 - Homo sapiens KIAA1160 protein, mRNA (cDNA clone IMAGE:3927759), partial cds. BC007409 - Homo sapiens ISY1 splicing factor homolog (S. cerevisiae), mRNA (cDNA clone MGC:2431 IMAGE:3030303), complete cds. BC019849 - Homo sapiens ISY1 splicing factor homolog (S. cerevisiae), mRNA (cDNA clone MGC:30028 IMAGE:4521880), complete cds. JD366284 - Sequence 347308 from Patent EP1572962. JD534755 - Sequence 515779 from Patent EP1572962. JD366283 - Sequence 347307 from Patent EP1572962. JD155806 - Sequence 136830 from Patent EP1572962. JD534754 - Sequence 515778 from Patent EP1572962. JD292538 - Sequence 273562 from Patent EP1572962. JD059714 - Sequence 40738 from Patent EP1572962. JD092086 - Sequence 73110 from Patent EP1572962. JD105774 - Sequence 86798 from Patent EP1572962. JD517385 - Sequence 498409 from Patent EP1572962. JD149302 - Sequence 130326 from Patent EP1572962. JD270183 - Sequence 251207 from Patent EP1572962. JD230268 - Sequence 211292 from Patent EP1572962. JD144059 - Sequence 125083 from Patent EP1572962. JD366272 - Sequence 347296 from Patent EP1572962. JD185292 - Sequence 166316 from Patent EP1572962. JD257714 - Sequence 238738 from Patent EP1572962. JD446917 - Sequence 427941 from Patent EP1572962. JD054995 - Sequence 36019 from Patent EP1572962. JD041651 - Sequence 22675 from Patent EP1572962. JD169525 - Sequence 150549 from Patent EP1572962. JD529330 - Sequence 510354 from Patent EP1572962. JD430268 - Sequence 411292 from Patent EP1572962. JD127726 - Sequence 108750 from Patent EP1572962. JD391640 - Sequence 372664 from Patent EP1572962. JD084385 - Sequence 65409 from Patent EP1572962. JD169524 - Sequence 150548 from Patent EP1572962. JD430267 - Sequence 411291 from Patent EP1572962. JD238472 - Sequence 219496 from Patent EP1572962. JD244665 - Sequence 225689 from Patent EP1572962. JD295913 - Sequence 276937 from Patent EP1572962. JD545845 - Sequence 526869 from Patent EP1572962. JD243299 - Sequence 224323 from Patent EP1572962. JD234943 - Sequence 215967 from Patent EP1572962. JD225777 - Sequence 206801 from Patent EP1572962. JD282215 - Sequence 263239 from Patent EP1572962. JD437796 - Sequence 418820 from Patent EP1572962. JD534641 - Sequence 515665 from Patent EP1572962. JD469923 - Sequence 450947 from Patent EP1572962. JD089067 - Sequence 70091 from Patent EP1572962. JD508799 - Sequence 489823 from Patent EP1572962. JD380095 - Sequence 361119 from Patent EP1572962. JD208705 - Sequence 189729 from Patent EP1572962. JD494818 - Sequence 475842 from Patent EP1572962. JD488586 - Sequence 469610 from Patent EP1572962. JD112102 - Sequence 93126 from Patent EP1572962. JD158913 - Sequence 139937 from Patent EP1572962. JD511665 - Sequence 492689 from Patent EP1572962. JD076535 - Sequence 57559 from Patent EP1572962. JD293971 - Sequence 274995 from Patent EP1572962. JD298127 - Sequence 279151 from Patent EP1572962. JD185609 - Sequence 166633 from Patent EP1572962. JD049308 - Sequence 30332 from Patent EP1572962. BC004442 - Homo sapiens ISY1 splicing factor homolog (S. cerevisiae), mRNA (cDNA clone MGC:4036 IMAGE:2820683), complete cds. DQ591844 - Homo sapiens piRNA piR-58956, complete sequence. JD106183 - Sequence 87207 from Patent EP1572962. JD358321 - Sequence 339345 from Patent EP1572962. JD535053 - Sequence 516077 from Patent EP1572962. JD147479 - Sequence 128503 from Patent EP1572962. JD385953 - Sequence 366977 from Patent EP1572962. KJ894429 - Synthetic construct Homo sapiens clone ccsbBroadEn_03823 ISY1 gene, encodes complete protein. DQ581885 - Homo sapiens piRNA piR-49997, complete sequence. DQ593067 - Homo sapiens piRNA piR-33179, complete sequence.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9ULR0 (Reactome details) participates in the following event(s):
R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-156661 Formation of Exon Junction Complex R-HSA-6782004 Assembly of the pre-incision complex in TC-NER R-HSA-6782069 UVSSA:USP7 deubiquitinates ERCC6 R-HSA-6782131 RNA Pol II backtracking in TC-NER R-HSA-6782138 ERCC5 and RPA bind TC-NER site R-HSA-6782211 DNA polymerases delta, epsilon or kappa bind the TC-NER site R-HSA-6782204 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER R-HSA-6782224 3' incision by ERCC5 (XPG) in TC-NER R-HSA-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER R-HSA-6782208 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER R-HSA-6782141 Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-6781823 Formation of TC-NER Pre-Incision Complex R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-72172 mRNA Splicing R-HSA-6782135 Dual incision in TC-NER R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-5696398 Nucleotide Excision Repair R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-73894 DNA Repair R-HSA-8953854 Metabolism of RNA
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
