ID:IRAK2_HUMAN DESCRIPTION: RecName: Full=Interleukin-1 receptor-associated kinase-like 2; Short=IRAK-2; FUNCTION: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. SUBUNIT: Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. INTERACTION: P10398:ARAF; NbExp=2; IntAct=EBI-447733, EBI-365961; P51617:IRAK1; NbExp=3; IntAct=EBI-447733, EBI-358664; Q9Y616:IRAK3; NbExp=3; IntAct=EBI-447733, EBI-447690; Q6PDS3:Sarm1 (xeno); NbExp=2; IntAct=EBI-447733, EBI-6117196; P46977:STT3A; NbExp=2; IntAct=EBI-447733, EBI-719212; Q13148:TARDBP; NbExp=2; IntAct=EBI-447733, EBI-372899; P58753:TIRAP; NbExp=2; IntAct=EBI-447733, EBI-528644; Q9H0E2:TOLLIP; NbExp=2; IntAct=EBI-447733, EBI-74615; Q9Y4K3:TRAF6; NbExp=3; IntAct=EBI-447733, EBI-359276; Q5D1E8:ZC3H12A; NbExp=2; IntAct=EBI-447733, EBI-747793; TISSUE SPECIFICITY: Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes. DOMAIN: The protein kinase domain is predicted to be catalytically inactive. SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. SIMILARITY: Contains 1 death domain. SIMILARITY: Contains 1 protein kinase domain. CAUTION: Asn-335 is present instead of the conserved Asp which is expected to be an active site residue. This enzyme has been shown to be catalytically inactive.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O43187
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LF384170 - JP 2014500723-A/191673: Polycomb-Associated Non-Coding RNAs. BC125184 - Homo sapiens interleukin-1 receptor-associated kinase 2, mRNA (cDNA clone MGC:150550 IMAGE:40122282), complete cds. AK299033 - Homo sapiens cDNA FLJ57341 complete cds, highly similar to Interleukin-1 receptor-associated kinase-like 2. AK312841 - Homo sapiens cDNA, FLJ93282, highly similar to Homo sapiens interleukin-1 receptor-associated kinase 2 (IRAK2),mRNA. AF026273 - Homo sapiens interleukin-1 receptor-associated kinase-2 mRNA, complete cds. AB587544 - Synthetic construct DNA, clone: pF1KE0990, Homo sapiens IRAK2 gene for interleukin-1 receptor-associated kinase 2, without stop codon, in Flexi system. KJ891485 - Synthetic construct Homo sapiens clone ccsbBroadEn_00879 IRAK2 gene, encodes complete protein. AJ496794 - Homo sapiens partial mRNA for interleukin-1 receptor associated kinase-2 (IRAK-2 gene). MA619747 - JP 2018138019-A/191673: Polycomb-Associated Non-Coding RNAs. LF365186 - JP 2014500723-A/172689: Polycomb-Associated Non-Coding RNAs. MA600763 - JP 2018138019-A/172689: Polycomb-Associated Non-Coding RNAs. LF365193 - JP 2014500723-A/172696: Polycomb-Associated Non-Coding RNAs. LF365194 - JP 2014500723-A/172697: Polycomb-Associated Non-Coding RNAs. JD123173 - Sequence 104197 from Patent EP1572962. JD200575 - Sequence 181599 from Patent EP1572962. JD479411 - Sequence 460435 from Patent EP1572962. JD420597 - Sequence 401621 from Patent EP1572962. JD184962 - Sequence 165986 from Patent EP1572962. JD208517 - Sequence 189541 from Patent EP1572962. JD168644 - Sequence 149668 from Patent EP1572962. JD165950 - Sequence 146974 from Patent EP1572962. JD177300 - Sequence 158324 from Patent EP1572962. JD102897 - Sequence 83921 from Patent EP1572962. JD063097 - Sequence 44121 from Patent EP1572962. JD303356 - Sequence 284380 from Patent EP1572962. JD467119 - Sequence 448143 from Patent EP1572962. JD498323 - Sequence 479347 from Patent EP1572962. JD181497 - Sequence 162521 from Patent EP1572962. JD377348 - Sequence 358372 from Patent EP1572962. JD103885 - Sequence 84909 from Patent EP1572962. LF365195 - JP 2014500723-A/172698: Polycomb-Associated Non-Coding RNAs. JD431796 - Sequence 412820 from Patent EP1572962. JD043704 - Sequence 24728 from Patent EP1572962. JD525923 - Sequence 506947 from Patent EP1572962. JD070414 - Sequence 51438 from Patent EP1572962. JD150764 - Sequence 131788 from Patent EP1572962. JD342207 - Sequence 323231 from Patent EP1572962. JD342208 - Sequence 323232 from Patent EP1572962. JD488148 - Sequence 469172 from Patent EP1572962. JD506087 - Sequence 487111 from Patent EP1572962. JD108186 - Sequence 89210 from Patent EP1572962. JD084676 - Sequence 65700 from Patent EP1572962. JD111573 - Sequence 92597 from Patent EP1572962. JD467588 - Sequence 448612 from Patent EP1572962. MA600770 - JP 2018138019-A/172696: Polycomb-Associated Non-Coding RNAs. MA600771 - JP 2018138019-A/172697: Polycomb-Associated Non-Coding RNAs. MA600772 - JP 2018138019-A/172698: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_il1rPathway - Signal transduction through IL1R
Reactome (by CSHL, EBI, and GO)
Protein O43187 (Reactome details) participates in the following event(s):
R-HSA-166091 IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:Mal complex R-HSA-975115 IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. R-HSA-975852 IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex R-HSA-936963 IRAK2 induces TRAF6 oligomerization R-HSA-2262775 Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:Mal:p-IRAK4 complex R-HSA-936960 Activated TRAF6:p-IRAK2 interacts with TAK1 complex R-HSA-2262777 TRAF6 binds to p-IRAK2 R-HSA-937059 Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:Mal:activated TLR complex R-HSA-975861 Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex R-HSA-975160 Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 R-HSA-975185 IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments R-HSA-975097 Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975879 Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex R-HSA-936991 Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 R-HSA-975857 TRAF6 binds to hp- IRAK1 or p-IRAK2 R-HSA-975103 Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation R-HSA-975100 Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex R-HSA-975111 TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 R-HSA-168184 Activated TAK1 mediates phosphorylation of the IKK Complex R-HSA-450337 Activated TAK1 phosphorylates MKK4/MKK7 R-HSA-450346 activated human TAK1 phosphorylates MKK3/MKK6 R-HSA-9020702 Interleukin-1 signaling R-HSA-446652 Interleukin-1 family signaling R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane R-HSA-975155 MyD88 dependent cascade initiated on endosome R-HSA-975871 MyD88 cascade initiated on plasma membrane R-HSA-937042 IRAK2 mediated activation of TAK1 complex R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-449147 Signaling by Interleukins R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-168898 Toll-Like Receptors Cascades R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-168638 NOD1/2 Signaling Pathway R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450302 activated TAK1 mediates p38 MAPK activation R-HSA-168256 Immune System R-HSA-168249 Innate Immune System R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-450294 MAP kinase activation R-HSA-166166 MyD88-independent TLR4 cascade R-HSA-448424 Interleukin-17 signaling
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
