ID:IPO5_HUMAN DESCRIPTION: RecName: Full=Importin-5; Short=Imp5; AltName: Full=Importin subunit beta-3; AltName: Full=Karyopherin beta-3; AltName: Full=Ran-binding protein 5; Short=RanBP5; FUNCTION: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. SUBUNIT: Binds RPL23A, RPS7 and RPL5. Interacts with H2A, H2B, H3 and H4 histones (By similarity). Binds to HIV-1 Rev. INTERACTION: O95166:GABARAP; NbExp=6; IntAct=EBI-356424, EBI-712001; Q9H0R8:GABARAPL1; NbExp=4; IntAct=EBI-356424, EBI-746969; P60520:GABARAPL2; NbExp=4; IntAct=EBI-356424, EBI-720116; Q9GZQ8:MAP1LC3B; NbExp=2; IntAct=EBI-356424, EBI-373144; Q9BXW4:MAP1LC3C; NbExp=2; IntAct=EBI-356424, EBI-2603996; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Nucleus; nuclear rim. Found particularly in the nuclear rim and nucleolus. SIMILARITY: Belongs to the importin beta family. SIMILARITY: Contains 6 HEAT repeats. SIMILARITY: Contains 1 importin N-terminal domain. SEQUENCE CAUTION: Sequence=CAA70103.1; Type=Frameshift; Positions=18;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O00410
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000060 protein import into nucleus, translocation GO:0006607 NLS-bearing protein import into nucleus GO:0006610 ribosomal protein import into nucleus GO:0006886 intracellular protein transport GO:0015031 protein transport GO:0016032 viral process GO:0034260 negative regulation of GTPase activity GO:0042307 positive regulation of protein import into nucleus GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0071230 cellular response to amino acid stimulus
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
