ID:INCE_HUMAN DESCRIPTION: RecName: Full=Inner centromere protein; FUNCTION: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Probably acts through association with AURKB or AURKC. Seems to bind directly to microtubules. Controls the kinetochore localization of BUB1. SUBUNIT: Homodimer or heterodimer. Interacts with H2AFZ (By similarity). Interacts with CBX3. Interacts with tubulin beta chain. Interacts with AURKB and AURKC. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB and AURKC. Interacts with EVI5. Interacts with CDCA8 and BIRC5; interaction is direct. Interacts with CBX5; POGZ and INCENP compete for interaction with CBX5. Interacts with POGZ. Interacts with JTB. INTERACTION: Q96GD4:AURKB; NbExp=3; IntAct=EBI-307907, EBI-624291; P45973:CBX5; NbExp=6; IntAct=EBI-307907, EBI-78219; Q53HL2:CDCA8; NbExp=4; IntAct=EBI-307907, EBI-979174; SUBCELLULAR LOCATION: Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to inner kinetochore. Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with AURKB at mitotic chromosomes. PTM: Phosphorylation by AURKB at its C-terminal part is important for AURKB activation by INCENP. SIMILARITY: Belongs to the INCENP family. CAUTION: PubMed:11139336 experiments have been carried out partly in chicken and partly in human.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NQS7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK307633 - Homo sapiens cDNA, FLJ97581. BC098576 - Homo sapiens inner centromere protein antigens 135/155kDa, mRNA (cDNA clone MGC:111393 IMAGE:30924748), complete cds. AK056195 - Homo sapiens cDNA FLJ31633 fis, clone NT2RI2003407, highly similar to Inner centromere protein. AK310714 - Homo sapiens cDNA, FLJ17756. BC032678 - Homo sapiens inner centromere protein antigens 135/155kDa, mRNA (cDNA clone IMAGE:5563252). AY714053 - Homo sapiens inner centromere protein (INCENP) mRNA, complete cds. AF282265 - Homo sapiens inner centromere protein INCENP mRNA, complete cds. BC111732 - Homo sapiens inner centromere protein antigens 135/155kDa, mRNA (cDNA clone IMAGE:40035563), containing frame-shift errors. JD215520 - Sequence 196544 from Patent EP1572962. JD479650 - Sequence 460674 from Patent EP1572962. JD493496 - Sequence 474520 from Patent EP1572962. JD178312 - Sequence 159336 from Patent EP1572962. JD373079 - Sequence 354103 from Patent EP1572962. JD261928 - Sequence 242952 from Patent EP1572962. JD204524 - Sequence 185548 from Patent EP1572962. JD435966 - Sequence 416990 from Patent EP1572962. JD205393 - Sequence 186417 from Patent EP1572962. JD330587 - Sequence 311611 from Patent EP1572962. JD188807 - Sequence 169831 from Patent EP1572962. JD548969 - Sequence 529993 from Patent EP1572962. JD161995 - Sequence 143019 from Patent EP1572962. JD548632 - Sequence 529656 from Patent EP1572962. JD429957 - Sequence 410981 from Patent EP1572962. JD272464 - Sequence 253488 from Patent EP1572962. JD535962 - Sequence 516986 from Patent EP1572962. JD497292 - Sequence 478316 from Patent EP1572962. JD210211 - Sequence 191235 from Patent EP1572962. JD207352 - Sequence 188376 from Patent EP1572962. JD480360 - Sequence 461384 from Patent EP1572962. JD466679 - Sequence 447703 from Patent EP1572962. JD220652 - Sequence 201676 from Patent EP1572962. JD483623 - Sequence 464647 from Patent EP1572962. JD375838 - Sequence 356862 from Patent EP1572962. JD320332 - Sequence 301356 from Patent EP1572962. JD515740 - Sequence 496764 from Patent EP1572962. JD147528 - Sequence 128552 from Patent EP1572962. JD351178 - Sequence 332202 from Patent EP1572962. JD055603 - Sequence 36627 from Patent EP1572962. JD200767 - Sequence 181791 from Patent EP1572962. JD200065 - Sequence 181089 from Patent EP1572962. JD181206 - Sequence 162230 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9NQS7 (Reactome details) participates in the following event(s):
R-HSA-141409 Mad1 binds kinetochore R-HSA-375302 Kinetochore capture of astral microtubules R-HSA-5666129 CDC42:GTP recruits DIAPH2-2 to kinetochores R-HSA-5666169 Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 R-HSA-141431 MAD2 associates with the Mad1 kinetochore complex R-HSA-141439 Release of activated MAD2 from kinetochores R-HSA-2467811 Separation of sister chromatids R-HSA-2467809 ESPL1 (Separase) cleaves centromeric cohesin R-HSA-5666160 AURKB phosphorylates DIAPH2-2 at kinetochores R-HSA-141422 MAD2 converted to an inhibitory state via interaction with Mad1 R-HSA-1638821 PP2A-B56 dephosphorylates centromeric cohesin R-HSA-1638803 Phosphorylation of cohesin by PLK1 at centromeres R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-68877 Mitotic Prometaphase R-HSA-5663220 RHO GTPases Activate Formins R-HSA-4615885 SUMOylation of DNA replication proteins R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2467813 Separation of Sister Chromatids R-HSA-141424 Amplification of signal from the kinetochores R-HSA-68886 M Phase R-HSA-195258 RHO GTPase Effectors R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins R-HSA-68882 Mitotic Anaphase R-HSA-69618 Mitotic Spindle Checkpoint R-HSA-69278 Cell Cycle (Mitotic) R-HSA-194315 Signaling by Rho GTPases R-HSA-2990846 SUMOylation R-HSA-2555396 Mitotic Metaphase and Anaphase R-HSA-69620 Cell Cycle Checkpoints R-HSA-1640170 Cell Cycle R-HSA-162582 Signal Transduction R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
