Human Gene IMP3 (ENST00000403490.3_5) from GENCODE V47lift37 |
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 Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: IMP3_HUMAN
DESCRIPTION: RecName: Full=U3 small nucleolar ribonucleoprotein protein IMP3; Short=U3 snoRNP protein IMP3; AltName: Full=BRMS2;
FUNCTION: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
SUBUNIT: Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with MPHOSPH10.
SUBCELLULAR LOCATION: Nucleus, nucleolus.
SIMILARITY: Belongs to the ribosomal protein S4P family.
SIMILARITY: Contains 1 S4 RNA-binding domain.
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Primer design for this transcript
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MalaCards Disease Associations
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MalaCards Gene Search: IMP3
Diseases sorted by gene-association score: enchondroma (4)
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Comparative Toxicogenomics Database (CTD)
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 Common Gene Haplotype Alleles
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Press "+" in the title bar above to open this section.
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure
IPR022801 - Ribosomal_S4/S9
IPR002942 - S4_RNA-bd
Pfam Domains:
PF00163 - Ribosomal protein S4/S9 N-terminal domain
PF01479 - S4 domain
SCOP Domains:
55174 - Alpha-L RNA-binding motif
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on Q9NV31
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Descriptions from all associated GenBank mRNAs
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AK057531 - Homo sapiens cDNA FLJ32969 fis, clone TESTI2008835, highly similar to U3 small nucleolar ribonucleoprotein protein IMP3.
BC020557 - Homo sapiens IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast), mRNA (cDNA clone IMAGE:3448061), with apparent retained intron.
BC006487 - Homo sapiens IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast), mRNA (cDNA clone MGC:910 IMAGE:3546883), complete cds.
LF208508 - JP 2014500723-A/16011: Polycomb-Associated Non-Coding RNAs.
AK223121 - Homo sapiens mRNA for U3 snoRNP protein 3 homolog, clone: KAT09342.
AY050497 - Homo sapiens BRMS2 mRNA, complete cds.
BC070348 - Homo sapiens cDNA clone IMAGE:4048797, partial cds.
AL136913 - Homo sapiens mRNA; cDNA DKFZp586L0118 (from clone DKFZp586L0118).
BC011745 - Homo sapiens IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast), mRNA (cDNA clone MGC:19665 IMAGE:3344519), complete cds.
AK001830 - Homo sapiens cDNA FLJ10968 fis, clone PLACE1000863, moderately similar to PUTATIVE MITOCHONDRIAL 40S RIBOSOMAL PROTEIN YHR148W.
JD498918 - Sequence 479942 from Patent EP1572962.
JD488824 - Sequence 469848 from Patent EP1572962.
JD151150 - Sequence 132174 from Patent EP1572962.
JD172315 - Sequence 153339 from Patent EP1572962.
JD042124 - Sequence 23148 from Patent EP1572962.
JD473217 - Sequence 454241 from Patent EP1572962.
JD119423 - Sequence 100447 from Patent EP1572962.
JD271899 - Sequence 252923 from Patent EP1572962.
KJ906224 - Synthetic construct Homo sapiens clone ccsbBroadEn_15894 IMP3 gene, encodes complete protein.
CU675427 - Synthetic construct Homo sapiens gateway clone IMAGE:100020629 5' read IMP3 mRNA.
KJ899108 - Synthetic construct Homo sapiens clone ccsbBroadEn_08502 IMP3 gene, encodes complete protein.
AB463774 - Synthetic construct DNA, clone: pF1KB7092, Homo sapiens IMP3 gene for IMP3, U3 small nucleolar ribonucleoprotein, homolog, without stop codon, in Flexi system.
AM393583 - Synthetic construct Homo sapiens clone IMAGE:100002103 for hypothetical protein (IMP3 gene).
LF377184 - JP 2014500723-A/184687: Polycomb-Associated Non-Coding RNAs.
CU680036 - Synthetic construct Homo sapiens gateway clone IMAGE:100020632 5' read IMP3 mRNA.
LF377183 - JP 2014500723-A/184686: Polycomb-Associated Non-Coding RNAs.
MA444085 - JP 2018138019-A/16011: Polycomb-Associated Non-Coding RNAs.
MA612761 - JP 2018138019-A/184687: Polycomb-Associated Non-Coding RNAs.
MA612760 - JP 2018138019-A/184686: Polycomb-Associated Non-Coding RNAs.
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Biochemical and Signaling Pathways
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Reactome (by CSHL, EBI, and GO)
Protein Q9NV31 (Reactome details) participates in the following event(s):
R-HSA-6790906 EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-8868773 rRNA processing in the nucleus and cytosol
R-HSA-72312 rRNA processing
R-HSA-8953854 Metabolism of RNA
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Other Names for This Gene
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Alternate Gene Symbols: B3KQ67, C15orf12, ENST00000403490.1, ENST00000403490.2, IMP3 , IMP3_HUMAN, MRPS4, NM_018285, Q53G10, Q9NV31, uc319cgf.1, uc319cgf.2
UCSC ID: ENST00000403490.3_5
RefSeq Accession: NM_018285.4
Protein: Q9NV31
(aka IMP3_HUMAN)
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Gene Model Information
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Click here
for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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Click here
for details on how this gene model was made and data restrictions if any.
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US Server
