ID:I22R2_HUMAN DESCRIPTION: RecName: Full=Interleukin-22 receptor subunit alpha-2; Short=IL-22 receptor subunit alpha-2; Short=IL-22R-alpha-2; Short=IL-22RA2; AltName: Full=Cytokine receptor class-II member 10; AltName: Full=Cytokine receptor family 2 member 10; Short=CRF2-10; AltName: Full=Cytokine receptor family type 2, soluble 1; Short=CRF2-S1; AltName: Full=Interleukin-22-binding protein; Short=IL-22BP; Short=IL22BP; AltName: Full=ZcytoR16; Flags: Precursor; FUNCTION: Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses. FUNCTION: Isoform 1 may play a role in establishing and maintaining successful pregnancy. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placenta. Isoform 2 is expressed in placenta and breast and at lower level in spleen, skin, thymus and stomach. SIMILARITY: Belongs to the type II cytokine receptor family. SIMILARITY: Contains 3 fibronectin type-III domains. SEQUENCE CAUTION: Sequence=AAQ89097.1; Type=Erroneous initiation; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il22ra2/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q969J5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0019221 cytokine-mediated signaling pathway GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO:0050728 negative regulation of inflammatory response
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
