ID:I18RA_HUMAN DESCRIPTION: RecName: Full=Interleukin-18 receptor accessory protein; Short=IL-18 receptor accessory protein; Short=IL-18RAcP; AltName: Full=Accessory protein-like; Short=AcPL; AltName: Full=CD218 antigen-like family member B; AltName: Full=CDw218b; AltName: Full=IL-1R accessory protein-like; Short=IL-1RAcPL; AltName: Full=Interleukin-1 receptor 7; Short=IL-1R-7; Short=IL-1R7; AltName: Full=Interleukin-18 receptor accessory protein-like; AltName: Full=Interleukin-18 receptor beta; Short=IL-18R-beta; Short=IL-18Rbeta; AltName: CD_antigen=CD218b; Flags: Precursor; FUNCTION: Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex (By similarity). Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK. SUBUNIT: Together with IL18R1, probably belongs to the IL-18 receptor complex. Seems not to interact directly with IL-18. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). TISSUE SPECIFICITY: Strongly expressed in peripheral blood leukocytes, spleen, lung, and, to a lesser extent, in colon, but not in any other tissue tested. Strongly expressed in T-cells polarized with IL-12. Specifically coexpressed with IL18R1 in Th1 cells. INDUCTION: Induced by IFN-alpha and IL12/interleukin-12 in natural killer (NK) cells and T-cells. SIMILARITY: Belongs to the interleukin-1 receptor family. SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. SIMILARITY: Contains 1 TIR domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95256
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
