Human Gene IL18BP (ENST00000393703.9_10) from GENCODE V47lift37

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Description: interleukin 18 binding protein, transcript variant F (from RefSeq NM_001039660.2)
Gencode Transcript: ENST00000393703.9_10
Gencode Gene: ENSG00000137496.19_13
Transcript (Including UTRs)
Position: hg19 chr11:71,709,955-71,713,850 Size: 3,896 Total Exon Count: 6 Strand: +
Coding Region
Position: hg19 chr11:71,711,031-71,712,907 Size: 1,877 Coding Exon Count: 5

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr11:71,709,955-71,713,850)			mRNA (may differ from genome)		Protein (194 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	Reactome
UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: I18BP_HUMAN DESCRIPTION: RecName: Full=Interleukin-18-binding protein; Short=IL-18BP; AltName: Full=Tadekinig-alfa; Flags: Precursor; FUNCTION: Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. SUBCELLULAR LOCATION: Secreted (Potential). TISSUE SPECIFICITY: Strongly expressed in heart, lung, placenta and spleen. PTM: N- and O-glycosylated. O-glycosylated with core 1-like and core 2-like glycans. O-glycan heterogeneity at Ser-53: HexHexNAc (major) and Hex2HexNAc2 (minor). N-glycan heterogeneity at Asn- 103: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major) and Hex6HexNAc5 (minor); N-glycan at Asn-147: dHex1Hex5HexNAc4. SIMILARITY: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. SEQUENCE CAUTION: Sequence=AAD17187.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAD17188.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAD17189.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAD17190.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAD17191.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAD17192.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAF31697.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: IL18BP Diseases sorted by gene-association score: molluscum contagiosum (8), gillessen-kaesbach-nishimura syndrome (6), crohn's disease (5), wegener granulomatosis (2)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C070046 1,2-dioleoyloxy-3-(trimethylammonium)propane C009505 4,4'-diaminodiphenylmethane D000643 Ammonium Chloride D001564 Benzo(a)pyrene D002784 Cholesterol D003042 Cocaine D004997 Ethinyl Estradiol D005419 Flavonoids D007213 Indomethacin D010634 Phenobarbital D053260 Soot D013749 Tetrachlorodibenzodioxin C044887 beta-methylcholine C008261 lead acetate C016030 pantogab C006253 pirinixic acid

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 11.22 RPKM in Spleen Total median expression: 172.51 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-47.90	169	-0.283	Picture	PostScript	Text
3' UTR	-272.20	943	-0.289	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like

SCOP Domains:
48726 - Immunoglobulin

ModBase Predicted Comparative 3D Structure on O95998


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0042007 interleukin-18 binding GO:0048019 receptor antagonist activity Biological Process: GO:0032496 response to lipopolysaccharide GO:0035655 interleukin-18-mediated signaling pathway GO:0042088 T-helper 1 type immune response GO:0070301 cellular response to hydrogen peroxide GO:0071345 cellular response to cytokine stimulus GO:0071356 cellular response to tumor necrosis factor GO:1900116 extracellular negative regulation of signal transduction Cellular Component: GO:0005576 extracellular region GO:0005615 extracellular space GO:0070062 extracellular exosome

Descriptions from all associated GenBank mRNAs


	AK098255 - Homo sapiens cDNA FLJ40936 fis, clone UTERU2007267, highly similar to Homo sapiens interleukin 18 binding protein (IL18BP), transcript variant A, mRNA. LF207800 - JP 2014500723-A/15303: Polycomb-Associated Non-Coding RNAs. AF215907 - Homo sapiens interleukin-18 binding protein d (IL18BP) mRNA, complete cds. BC044215 - Homo sapiens interleukin 18 binding protein, mRNA (cDNA clone MGC:49873 IMAGE:5755934), complete cds. JD507107 - Sequence 488131 from Patent EP1572962. JD560182 - Sequence 541206 from Patent EP1572962. AF110801 - Homo sapiens interleukin-18 binding protein c precursor (IL18BP) mRNA, complete cds. AF122906 - Homo sapiens MC51L-53L-54L homolog mRNA, complete cds. JD253235 - Sequence 234259 from Patent EP1572962. JD124460 - Sequence 105484 from Patent EP1572962. AF110799 - Homo sapiens interleukin-18 binding protein a precursor (IL18BP) mRNA, complete cds. AF110800 - Homo sapiens interleukin-18 binding protein b precursor (IL18BP) mRNA, complete cds. JD173771 - Sequence 154795 from Patent EP1572962. CU692186 - Synthetic construct Homo sapiens gateway clone IMAGE:100021281 5' read IL18BP mRNA. AB590783 - Synthetic construct DNA, clone: pFN21AE1681, Homo sapiens IL18BP gene for interleukin 18 binding protein, without stop codon, in Flexi system. HQ448621 - Synthetic construct Homo sapiens clone IMAGE:100072060; CCSB011365_01 interleukin 18 binding protein (IL18BP) gene, encodes complete protein. AB019504 - Homo sapiens mRNA for interleukin-18 binding protein, complete cds. JD195280 - Sequence 176304 from Patent EP1572962. JD042708 - Sequence 23732 from Patent EP1572962. JD192669 - Sequence 173693 from Patent EP1572962. JD132311 - Sequence 113335 from Patent EP1572962. JD149176 - Sequence 130200 from Patent EP1572962. JD370378 - Sequence 351402 from Patent EP1572962. JD068198 - Sequence 49222 from Patent EP1572962. JD186706 - Sequence 167730 from Patent EP1572962. JD206226 - Sequence 187250 from Patent EP1572962. JD039545 - Sequence 20569 from Patent EP1572962. JD399070 - Sequence 380094 from Patent EP1572962. JD411617 - Sequence 392641 from Patent EP1572962. JD460366 - Sequence 441390 from Patent EP1572962. JD290324 - Sequence 271348 from Patent EP1572962. JD058181 - Sequence 39205 from Patent EP1572962. JD096126 - Sequence 77150 from Patent EP1572962. JD324841 - Sequence 305865 from Patent EP1572962. JD156687 - Sequence 137711 from Patent EP1572962. JD424799 - Sequence 405823 from Patent EP1572962. AF086560 - Homo sapiens full length insert cDNA clone ZE16A02. JD259563 - Sequence 240587 from Patent EP1572962. JD261208 - Sequence 242232 from Patent EP1572962. JD126173 - Sequence 107197 from Patent EP1572962. JD276372 - Sequence 257396 from Patent EP1572962. JD484424 - Sequence 465448 from Patent EP1572962. JD123212 - Sequence 104236 from Patent EP1572962. JD355226 - Sequence 336250 from Patent EP1572962. JD114087 - Sequence 95111 from Patent EP1572962. JD121981 - Sequence 103005 from Patent EP1572962. JD445564 - Sequence 426588 from Patent EP1572962. JD102710 - Sequence 83734 from Patent EP1572962. JD205473 - Sequence 186497 from Patent EP1572962. JD539030 - Sequence 520054 from Patent EP1572962. JD039131 - Sequence 20155 from Patent EP1572962. JD343430 - Sequence 324454 from Patent EP1572962. JD436174 - Sequence 417198 from Patent EP1572962. MA443377 - JP 2018138019-A/15303: Polycomb-Associated Non-Coding RNAs.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein O95998 (Reactome details) participates in the following event(s): R-HSA-8848392 IL18BP binds IL18 R-HSA-9008587 IL37, IL37(?-218) binds IL18BP R-HSA-9012546 Interleukin-18 signaling R-HSA-9008059 Interleukin-37 signaling R-HSA-446652 Interleukin-1 family signaling R-HSA-449147 Signaling by Interleukins R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-168256 Immune System

Other Names for This Gene


	Alternate Gene Symbols: B3KUZ0, B7WPK4, ENST00000393703.1, ENST00000393703.2, ENST00000393703.3, ENST00000393703.4, ENST00000393703.5, ENST00000393703.6, ENST00000393703.7, ENST00000393703.8, I18BP_HUMAN, NM_001039660, O95993, O95998, O96027, Q9NZA9, Q9UBR7, uc318wbk.1, uc318wbk.2 UCSC ID: ENST00000393703.9_10 RefSeq Accession: NM_001039660.2 Protein: O95998 (aka I18BP_HUMAN or I18B_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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