Human Gene IL17RB (ENST00000288167.8_4) from GENCODE V47lift37
  Description: interleukin 17 receptor B (from RefSeq NM_018725.4)
Gencode Transcript: ENST00000288167.8_4
Gencode Gene: ENSG00000056736.10_10
Transcript (Including UTRs)
   Position: hg19 chr3:53,880,595-53,899,821 Size: 19,227 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chr3:53,880,616-53,899,335 Size: 18,720 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:53,880,595-53,899,821)mRNA (may differ from genome)Protein (502 aa)
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UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: I17RB_HUMAN
DESCRIPTION: RecName: Full=Interleukin-17 receptor B; Short=IL-17 receptor B; Short=IL-17RB; AltName: Full=Cytokine receptor-like 4; AltName: Full=IL-17 receptor homolog 1; Short=IL-17Rh1; Short=IL17Rh1; AltName: Full=Interleukin-17B receptor; Short=IL-17B receptor; Flags: Precursor;
FUNCTION: Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.
SUBUNIT: Interacts with DAZAP2.
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein.
SUBCELLULAR LOCATION: Isoform 2: Secreted.
TISSUE SPECIFICITY: Expressed in several endocrine tissues, mostly in fetal and adult liver, kidney, pancreas, testis, colon, brain and small intestine; not detected in peripheral blood leukocytes, lymphoid organs, and most cell lines.
SIMILARITY: Contains 1 SEFIR domain.
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il17rb/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: IL17RB
Diseases sorted by gene-association score: chronic mucocutaneous candidiasis (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 32.00 RPKM in Kidney - Cortex
Total median expression: 334.73 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -5.1021-0.243 Picture PostScript Text
3' UTR -73.30486-0.151 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013568 - SEFIR

Pfam Domains:
PF08357 - SEFIR domain
PF16556 - Interleukin-17 receptor, fibronectin-III-like domain 1
PF16578 - Interleukin 17 receptor D

ModBase Predicted Comparative 3D Structure on Q9NRM6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004896 cytokine receptor activity
GO:0030368 interleukin-17 receptor activity

Biological Process:
GO:0001558 regulation of cell growth
GO:0006952 defense response
GO:0050729 positive regulation of inflammatory response
GO:0097400 interleukin-17-mediated signaling pathway
GO:2000664 positive regulation of interleukin-5 secretion
GO:2000667 positive regulation of interleukin-13 secretion

Cellular Component:
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK307749 - Homo sapiens cDNA, FLJ97697.
BC000980 - Homo sapiens interleukin 17 receptor B, mRNA (cDNA clone MGC:5245 IMAGE:2985728), complete cds.
AY359122 - Homo sapiens DNA115291 IL17BR (UNQ2501) mRNA, complete cds.
AF208110 - Homo sapiens IL-17 receptor homolog precursor (EVI27) mRNA, complete cds.
AF208111 - Homo sapiens truncated IL-17 receptor homolog precursor (EVI27) mRNA, complete cds.
AF212365 - Homo sapiens IL-17B receptor (IL17BR) mRNA, complete cds.
DQ894090 - Synthetic construct Homo sapiens clone IMAGE:100008550; FLH167601.01L; RZPDo839D0189D interleukin 17 receptor B (IL17RB) gene, encodes complete protein.
DQ890929 - Synthetic construct clone IMAGE:100003559; FLH167605.01X; RZPDo839D0190D interleukin 17 receptor B (IL17RB) gene, encodes complete protein.
AF250309 - Homo sapiens putative cytokine receptor CRL4 precusor mRNA, complete cds.
JD466221 - Sequence 447245 from Patent EP1572962.
JD200432 - Sequence 181456 from Patent EP1572962.
JD424246 - Sequence 405270 from Patent EP1572962.
JD111990 - Sequence 93014 from Patent EP1572962.
JD038953 - Sequence 19977 from Patent EP1572962.
JD326633 - Sequence 307657 from Patent EP1572962.
JD343655 - Sequence 324679 from Patent EP1572962.
JD412357 - Sequence 393381 from Patent EP1572962.
JD185988 - Sequence 167012 from Patent EP1572962.
JD248591 - Sequence 229615 from Patent EP1572962.
JD056943 - Sequence 37967 from Patent EP1572962.
JD377103 - Sequence 358127 from Patent EP1572962.
JD086833 - Sequence 67857 from Patent EP1572962.
JD417409 - Sequence 398433 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9NRM6 (Reactome details) participates in the following event(s):

R-HSA-448424 Interleukin-17 signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: CRL4, ENST00000288167.1, ENST00000288167.2, ENST00000288167.3, ENST00000288167.4, ENST00000288167.5, ENST00000288167.6, ENST00000288167.7, EVI27, I17RB_HUMAN, IL17BR, NM_018725, Q9BPZ0, Q9NRL4, Q9NRM5, Q9NRM6, uc317kpc.1, uc317kpc.2, UNQ2501/PRO19612
UCSC ID: ENST00000288167.8_4
RefSeq Accession: NM_018725.4
Protein: Q9NRM6 (aka I17RB_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.