Human Gene IL17D (ENST00000682841.1_2) from GENCODE V47lift37

JavaScript is disabled in your web browser

You must have JavaScript enabled in your web browser to use the Genome Browser

Description: interleukin 17D, transcript variant 5 (from RefSeq NM_001385224.1)
Gencode Transcript: ENST00000682841.1_2
Gencode Gene: ENSG00000172458.5_8
Transcript (Including UTRs)
Position: hg19 chr13:21,277,838-21,297,237 Size: 19,400 Total Exon Count: 2 Strand: +
Coding Region
Position: hg19 chr13:21,278,141-21,296,093 Size: 17,953 Coding Exon Count: 2

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr13:21,277,838-21,297,237)			mRNA (may differ from genome)		Protein (202 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: IL17D_HUMAN DESCRIPTION: RecName: Full=Interleukin-17D; Short=IL-17D; AltName: Full=Interleukin-27; Short=IL-27; Flags: Precursor; FUNCTION: Induces expression of IL-6, IL-8, and GM-CSF from endothelial cells. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Expressed preferentially in adipose, skeletal muscle and CNS. SIMILARITY: Belongs to the IL-17 family. WEB RESOURCE: Name=Wikipedia; Note=Interleukin-17 entry; URL="http://en.wikipedia.org/wiki/Interleukin_17";

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D000082 Acetaminophen D000111 Acetylcysteine D016604 Aflatoxin B1 D004052 Diethylnitrosamine D012906 Smoke C006780 bisphenol A C016517 indole-3-carbinol C089730 rosiglitazone C015559 trimellitic anhydride

Common Gene Haplotype Alleles


	Press "+" in the title bar above to open this section.

Microarray Expression Data


	Press "+" in the title bar above to open this section.

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-212.70	303	-0.702	Picture	PostScript	Text
3' UTR	-376.40	1144	-0.329	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR010345 - Interleukin-17
IPR020440 - Interleukin-17_chordata

Pfam Domains:
PF06083 - Interleukin-17

SCOP Domains:
57501 - Cystine-knot cytokines

ModBase Predicted Comparative 3D Structure on Q8TAD2


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005125 cytokine activity GO:0042803 protein homodimerization activity GO:0048018 receptor agonist activity Biological Process: GO:0006954 inflammatory response GO:0010469 regulation of receptor activity GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032755 positive regulation of interleukin-6 production GO:0032757 positive regulation of interleukin-8 production GO:1900017 positive regulation of cytokine production involved in inflammatory response GO:1903707 negative regulation of hemopoiesis Cellular Component: GO:0005576 extracellular region GO:0005615 extracellular space

Descriptions from all associated GenBank mRNAs


	AY078238 - Homo sapiens interleukin 27 precursor (IL27) mRNA, complete cds. BC036243 - Homo sapiens interleukin 17D, mRNA (cDNA clone MGC:39828 IMAGE:5301608), complete cds. AF458062 - Homo sapiens IL-17D mRNA, complete cds. AB590340 - Synthetic construct DNA, clone: pFN21AB5261, Homo sapiens IL17D gene for interleukin 17D, without stop codon, in Flexi system. DQ890720 - Synthetic construct clone IMAGE:100003350; FLH165449.01X; RZPDo839C06160D interleukin 17D (IL17D) gene, encodes complete protein. AF479775 - Homo sapiens IL17D precursor, mRNA, complete cds. AY359113 - Homo sapiens clone DNA173894 IL17D (UNQ3096) mRNA, complete cds. AK123964 - Homo sapiens cDNA FLJ41970 fis, clone SKMUS2006755. JD518878 - Sequence 499902 from Patent EP1572962. JD067025 - Sequence 48049 from Patent EP1572962. JD049589 - Sequence 30613 from Patent EP1572962. JD361294 - Sequence 342318 from Patent EP1572962. JD409195 - Sequence 390219 from Patent EP1572962. JD563794 - Sequence 544818 from Patent EP1572962. JD082500 - Sequence 63524 from Patent EP1572962. JD420291 - Sequence 401315 from Patent EP1572962. JD544034 - Sequence 525058 from Patent EP1572962. JD218718 - Sequence 199742 from Patent EP1572962. JD563536 - Sequence 544560 from Patent EP1572962. JD101107 - Sequence 82131 from Patent EP1572962. JD428666 - Sequence 409690 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: B1AM69, IL17D_HUMAN, NM_001385224, Q8TAD2, uc330knb.1, uc330knb.2, UNQ3096/PRO21175 UCSC ID: ENST00000682841.1_2 RefSeq Accession: NM_001385224.1 Protein: Q8TAD2 (aka IL17D_HUMAN or I17D_HUMAN)

Gene Model Information


	Click here for a detailed description of the fields of the table above.

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.