ID:IKZF4_HUMAN DESCRIPTION: RecName: Full=Zinc finger protein Eos; AltName: Full=Ikaros family zinc finger protein 4; FUNCTION: DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. SUBUNIT: Self-associates. Interacts with other family members; IKZF1, IKZF2, IKZF3 AND IKZF5. Interacts with CTBP2, SPI1 and MITF (By similarity). SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Highly expressed in skeletal muscle, low levels of expression in heart, thymus, kidney, liver, and spleen. Expressed in the hematopoietic cell lines MOLT-4, NALM-6 and K- 562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively. DOMAIN: The N-terminal zinc fingers are involved in sequence- specific DNA binding and heterotypic associations with other family members. DOMAIN: C-terminal zinc fingers mediate homodimerization. MISCELLANEOUS: 'Eos' means 'rising sun' in Greek. SIMILARITY: Belongs to the Ikaros C2H2-type zinc-finger protein family. SIMILARITY: Contains 6 C2H2-type zinc fingers. SEQUENCE CAUTION: Sequence=AAG39221.1; Type=Erroneous initiation; Sequence=BAB47411.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H2S9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0008270 zinc ion binding GO:0019904 protein domain specific binding GO:0042803 protein homodimerization activity GO:0043425 bHLH transcription factor binding GO:0043565 sequence-specific DNA binding GO:0044212 transcription regulatory region DNA binding GO:0046872 metal ion binding GO:0046982 protein heterodimerization activity
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0045892 negative regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0051260 protein homooligomerization GO:0051291 protein heterooligomerization
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
