Human Gene IGHG2 (ENST00000641095.1_10) from GENCODE V47lift37
  Description: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins- secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). (from UniProt P01859)
Gencode Transcript: ENST00000641095.1_10
Gencode Gene: ENSG00000211893.4_14
Transcript (Including UTRs)
   Position: hg19 chr14:106,105,896-106,111,127 Size: 5,232 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr14:106,107,302-106,111,127 Size: 3,826 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsGene Alleles
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:106,105,896-106,111,127)mRNA (may differ from genome)Protein (395 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldEnsemblExonPrimerGeneCardsHGNCMalacards
MGIPubMedReactomeUniProtKB

-  Comments and Description Text from UniProtKB
  ID: IGHG2_HUMAN
DESCRIPTION: RecName: Full=Ig gamma-2 chain C region;
SUBCELLULAR LOCATION: Secreted.
WEB RESOURCE: Name=IGHG2base; Note=IGHG2 mutation db; URL="http://bioinf.uta.fi/IGHG2base/";
WEB RESOURCE: Name=IMGT/GENE-DB; URL="http://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+IGHG2&species=Homo+sapiens";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: IGHG2
Diseases sorted by gene-association score: kappa light chain deficiency* (247), c2 deficiency (9)
* = Manually curated disease association

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -582.801406-0.415 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR003006 - Ig/MHC_CS
IPR003597 - Ig_C1-set

Pfam Domains:
PF07654 - Immunoglobulin C1-set domain
PF08205 - CD80-like C2-set immunoglobulin domain

SCOP Domains:
48726 - Immunoglobulin

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2QSC - X-ray


ModBase Predicted Comparative 3D Structure on P01859
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
 Gene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003823 antigen binding
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0034987 immunoglobulin receptor binding

Biological Process:
GO:0002250 adaptive immune response
GO:0002376 immune system process
GO:0006508 proteolysis
GO:0006910 phagocytosis, recognition
GO:0006911 phagocytosis, engulfment
GO:0006956 complement activation
GO:0006958 complement activation, classical pathway
GO:0030449 regulation of complement activation
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042742 defense response to bacterium
GO:0045087 innate immune response
GO:0050853 B cell receptor signaling pathway
GO:0050871 positive regulation of B cell activation

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0042571 immunoglobulin complex, circulating
GO:0070062 extracellular exosome
GO:0072562 blood microparticle


-  Descriptions from all associated GenBank mRNAs
  AK131045 - Homo sapiens cDNA FLJ29011 fis, clone DMC03382, highly similar to Ig gamma-2 chain C region.
BC025314 - Homo sapiens immunoglobulin heavy constant gamma 1 (G1m marker), mRNA (cDNA clone IMAGE:5450493).
AF184765 - Homo sapiens IgG2 heavy chain mRNA, partial cds.
AM233828 - Homo sapiens partial mRNA for immunoglobulin heavy chain variable region (IGHV5-51 gene), clone HP 75.
AM233830 - Homo sapiens partial mRNA for immunoglobulin heavy chain variable region (IGHV5-51 gene), clone HP 114.
AM233832 - Homo sapiens partial mRNA for immunoglobulin heavy chain variable region (IGHV5-51 gene), clone HP 119.
X94058 - H.sapiens mRNA for immunoglobulin heavy chain V-D-J region (clone ST IgG VH5 15).
AY393458 - Homo sapiens isolate RA129-G5-12.fa immunoglobulin heavy chain variable region mRNA, partial cds.
AY393459 - Homo sapiens isolate RA129-G5-13.fa immunoglobulin heavy chain variable region mRNA, partial cds.
AY393466 - Homo sapiens isolate RA129-G5-21.fa immunoglobulin heavy chain variable region mRNA, partial cds.
X94071 - H.sapiens mRNA for immunoglobulin heavy chain V-D-J region (clone ST IgG VH5 21).
AY393068 - Homo sapiens clone RA702-G3-30.fa immunoglobulin heavy chain mRNA, partial cds.
AY393373 - Homo sapiens isolate RA129-G1-79.fa immunoglobulin heavy chain variable region mRNA, partial cds.
X94055 - H.sapiens mRNA for immunoglobulin heavy chain V-D-J region (clone ST IgG VH5 13).
L22586 - Human immunoglobulin heavy chain (IGH@) mRNA, V region, 5' end.
X79159 - H.sapiens heavy chain variable region.
HM774234 - Homo sapiens clone P06G210 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM773990 - Homo sapiens clone P02G206 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774818 - Homo sapiens clone P12G230 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774920 - Homo sapiens clone P13G241 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM775016 - Homo sapiens clone P14G217 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774378 - Homo sapiens clone P08G213 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774923 - Homo sapiens clone P13G244 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM773968 - Homo sapiens clone P01G201 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM773995 - Homo sapiens clone P02G211 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774915 - Homo sapiens clone P13G236 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774591 - Homo sapiens clone P10G213 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774796 - Homo sapiens clone P12G207 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774808 - Homo sapiens clone P12G220 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774115 - Homo sapiens clone P04G209 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774299 - Homo sapiens clone P07G206 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774464 - Homo sapiens clone P09G224 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774708 - Homo sapiens clone P11G207 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM995768 - Homo sapiens isolate P3_Ass_3.4.16 immunoglobulin variable region mRNA, partial cds.
HM995656 - Homo sapiens isolate P3_Agg_5.2.2 immunoglobulin variable region mRNA, partial cds.
HM995525 - Homo sapiens isolate P2_Inf_1.6.10 immunoglobulin variable region mRNA, partial cds.
HM995942 - Homo sapiens isolate P3_Inf_8.1.10 immunoglobulin variable region mRNA, partial cds.
HM995174 - Homo sapiens isolate P2_Agg_1.2.3 immunoglobulin variable region mRNA, partial cds.
HM995178 - Homo sapiens isolate P2_Agg_1.2.5 immunoglobulin variable region mRNA, partial cds.
HM995450 - Homo sapiens isolate P2_Ass_2.5.5 immunoglobulin variable region mRNA, partial cds.
HM996020 - Homo sapiens isolate P5_PC23_HC immunoglobulin variable region mRNA, partial cds.
HM774774 - Homo sapiens clone P12G135 immunoglobulin gamma 1 heavy chain variable region mRNA, partial cds.
HM774007 - Homo sapiens clone P03G101 immunoglobulin gamma 1 heavy chain variable region mRNA, partial cds.
HM995076 - Homo sapiens isolate P2_Agg_5.3.4 immunoglobulin variable region mRNA, partial cds.
HM995081 - Homo sapiens isolate P2_Agg_5.3.12 immunoglobulin variable region mRNA, partial cds.
HM995353 - Homo sapiens isolate P2_Ass_1.4.5 immunoglobulin variable region mRNA, partial cds.
HM995729 - Homo sapiens isolate P3_Ass_3.2.2 immunoglobulin variable region mRNA, partial cds.
HM995928 - Homo sapiens isolate P3_Inf_6.2.13 immunoglobulin variable region mRNA, partial cds.
HM995932 - Homo sapiens isolate P3_Inf_6.3.5 immunoglobulin variable region mRNA, partial cds.
HM995866 - Homo sapiens isolate P3_Inf_2.2.4 immunoglobulin variable region mRNA, partial cds.
HM995241 - Homo sapiens isolate P2_Agg_2.3.8 immunoglobulin variable region mRNA, partial cds.
AK128421 - Homo sapiens cDNA FLJ46564 fis, clone THYMU3040746, highly similar to Ig gamma-2 chain C region.
CR749861 - Homo sapiens mRNA; cDNA DKFZp686E23209 (from clone DKFZp686E23209).
AK130609 - Homo sapiens cDNA FLJ27099 fis, clone SPL04664, highly similar to Ig gamma-2 chain C region.
AK097306 - Homo sapiens cDNA FLJ39987 fis, clone STOMA2000567, highly similar to Homo sapiens mRNA for immunoglobulin lambda heavy chain.
AK130614 - Homo sapiens cDNA FLJ27104 fis, clone SPL04981, highly similar to Ig gamma-2 chain C region.
BC062335 - Homo sapiens immunoglobulin heavy constant gamma 2 (G2m marker), mRNA (cDNA clone IMAGE:6281452).
BX640623 - Homo sapiens mRNA; cDNA DKFZp686I04196 (from clone DKFZp686I04196); complete cds.
BX640874 - Homo sapiens mRNA; cDNA DKFZp686C15213 (from clone DKFZp686C15213).
KJ904398 - Synthetic construct Homo sapiens clone ccsbBroadEn_13792 hypothetical protein, encodes complete protein.
KU951246 - Homo sapiens isolate 10E8v1 immunoglobulin heavy chain mRNA, partial cds.
KU951249 - Homo sapiens isolate 10E8v5 immunoglobulin heavy chain mRNA, partial cds.
AM183974 - Homo sapiens partial mRNA for immunoglobulin heavy chain (IGHV gene), cell line SP49.
AM183976 - Homo sapiens partial mRNA for immunoglobulin heavy chain (IGHV gene), cell line SP53, clone 2.
AB022655 - Homo sapiens mRNA for anti-Entamoeba histolytica immunoglobulin gamma heavy chain (V-CH1 region), partial cds, clone:E244-H1.
HF541904 - Homo sapiens partial mRNA for immunoglobulin heavy chain (VH3-7*01_DH4-17*01_JH5*01_C gamma2), isolate 09_22B.
AB453230 - Homo sapiens mRNA for immunoglobulin heavy chain, partial cds, clone: XEhI-20.
AB453231 - Homo sapiens mRNA for immunoglobulin heavy chain, partial cds, clone: XEhI-28.
AB453232 - Homo sapiens mRNA for immunoglobulin heavy chain, partial cds, clone: XEhI-B5.
DQ431663 - Homo sapiens immunoglobulin heavy chain Iepsilon-Cgamma fusion switch circle transcript mRNA sequence.
Z98720 - Homo sapiens mRNA for immunoglobulin heavy chain variable region, clone ToPG410.
Z98719 - Homo sapiens mRNA for immunoglobulin heavy chain variable region, clone ToPG344.
AY393011 - Homo sapiens clone RA702-G1-27.fa immunoglobulin heavy chain mRNA, partial cds.
AY393031 - Homo sapiens clone RA702-G2-17.fa immunoglobulin heavy chain mRNA, partial cds.
AY393039 - Homo sapiens clone RA702-G2-24.fa immunoglobulin heavy chain mRNA, partial cds.
DQ083946 - Homo sapiens immunoglobulin heavy chain Ialpha/Cgamma fusion switch-circle transcript mRNA, partial sequence.
AF013616 - Homo sapiens immunoglobulin heavy chain variable region (VH4) mRNA, VH4-31 allele, partial cds.
JX522547 - Homo sapiens clone HXBX-1-2 immunoglobulin gamma heavy chain mRNA, partial cds.
AM233818 - Homo sapiens partial mRNA for immunoglobulin heavy chain variable region (IGHV4-4 gene), clone HP 19.
AM233813 - Homo sapiens partial mRNA for immunoglobulin heavy chain variable region (IGHV4-31 gene), clone HP 50.
AM233820 - Homo sapiens partial mRNA for immunoglobulin heavy chain variable region (IGHV4-31 gene), clone HP 26.
AY393473 - Homo sapiens isolate RA129-G6-1.fa immunoglobulin heavy chain variable region mRNA, partial cds.
AY393476 - Homo sapiens isolate RA129-G6-13.fa immunoglobulin heavy chain variable region mRNA, partial cds.
AY393477 - Homo sapiens isolate RA129-G6-14/18/20/26.fa immunoglobulin heavy chain variable region mRNA, partial cds.
AY393484 - Homo sapiens isolate RA129-G6-23.fa immunoglobulin heavy chain variable region mRNA, partial cds.
AY393488 - Homo sapiens isolate RA129-G6-30.fa immunoglobulin heavy chain variable region mRNA, partial cds.
AY393490 - Homo sapiens isolate RA129-G6-5.fa immunoglobulin heavy chain variable region mRNA, partial cds.
AY393492 - Homo sapiens isolate RA129-G6-7.fa immunoglobulin heavy chain variable region mRNA, partial cds.
AY393354 - Homo sapiens isolate RA129-G1-45.fa immunoglobulin heavy chain variable region mRNA, partial cds.
AY393368 - Homo sapiens isolate RA129-G1-72.fa immunoglobulin heavy chain variable region mRNA, partial cds.
AY393666 - Homo sapiens clone RA130BM-G1-177 immunoglobulin heavy chain variable region mRNA, partial cds.
AY393382 - Homo sapiens isolate RA129-G2-1.fa immunoglobulin heavy chain variable region mRNA, partial cds.
AY393391 - Homo sapiens isolate RA129-G2-2.fa immunoglobulin heavy chain variable region mRNA, partial cds.
AY393392 - Homo sapiens isolate RA129-G2-21.fa immunoglobulin heavy chain variable region mRNA, partial cds.
AY393631 - Homo sapiens clone RA130BM-G1-137 immunoglobulin heavy chain variable region mRNA, partial cds.
AY393339 - Homo sapiens isolate RA129-G1-14.fa immunoglobulin heavy chain variable region mRNA, partial cds.
AY393066 - Homo sapiens clone RA702-G3-28.fa immunoglobulin heavy chain mRNA, partial cds.
AY393349 - Homo sapiens isolate RA129-G1-4.fa immunoglobulin heavy chain variable region mRNA, partial cds.
AY393375 - Homo sapiens isolate RA129-G1-83.fa immunoglobulin heavy chain variable region mRNA, partial cds.
AY393642 - Homo sapiens clone RA130BM-G1-151 immunoglobulin heavy chain variable region mRNA, partial cds.
AY393388 - Homo sapiens isolate RA129-G2-17.fa immunoglobulin heavy chain variable region mRNA, partial cds.
AY393397 - Homo sapiens isolate RA129-G2-27.fa immunoglobulin heavy chain variable region mRNA, partial cds.
AY393415 - Homo sapiens isolate RA129-G2-47.fa immunoglobulin heavy chain variable region mRNA, partial cds.
AY393428 - Homo sapiens isolate RA129-G2-6.fa nonfunctional immunoglobulin heavy chain mRNA, partial sequence.
AJ240575 - Homo sapiens mRNA for rearranged immunoglobulin G2 heavy chain, IgVH4-34-D-JH6B-Cgamma2, clone EU 74.
AJ240597 - Homo sapiens mRNA for rearranged immunoglobulin G heavy chain, IgVH4-34-D-JH3B-Cgamma, clone EU 45.
AY268373 - Homo sapiens clone CLL202 immunoglobulin heavy chain variable region mRNA, partial cds.
HM996035 - Homo sapiens isolate P5_PC36_HC immunoglobulin variable region mRNA, partial cds.
MG879981 - Homo sapiens isolate AW1_plasmablasts_Heavy_human_G5 immunoglobulin heavy chain variable region mRNA, partial cds.
AJ305231 - Homo sapiens mRNA for immunoglobulin heavy chain variable region V(D)J-rearrangement (IGHV gene), patient 10.
AY553646 - Homo sapiens clone CLL342 immunoglobulin gamma heavy chain variable region mRNA, partial cds.
HM996018 - Homo sapiens isolate P5_PC19_HC immunoglobulin variable region mRNA, partial cds.
FN562934 - Homo sapiens partial mRNA for immunoglobulin heavy chain variable region (IGHV1-18 gene), clone A, sub_clone IgM1.
FN562936 - Homo sapiens partial mRNA for immunoglobulin heavy chain variable region (IGHV1-18 gene), clone A, sub_clone IgG15.
FN562938 - Homo sapiens partial mRNA for immunoglobulin heavy chain variable region (IGHV1-18 gene), clone A, sub_clone IgG6.
FN562940 - Homo sapiens partial mRNA for immunoglobulin heavy chain variable region (IGHV1-18 gene), clone A, sub_clone IgG1.
FN562941 - Homo sapiens partial mRNA for immunoglobulin heavy chain variable region (IGHV1-18 gene), clone A, sub_clone IgG12.
FN562943 - Homo sapiens partial mRNA for immunoglobulin heavy chain variable region (IGHV1-18 gene), clone A, sub_clone IgG16.
FN562969 - Homo sapiens partial mRNA for immunoglobulin heavy chain variable region (IGHV1-18 gene), clone A, sub_clone IgM2.
FN562970 - Homo sapiens partial mRNA for immunoglobulin heavy chain variable region (IGHV1-18 gene), clone A, sub_clone IgG7.
FN562971 - Homo sapiens partial mRNA for immunoglobulin heavy chain variable region (IGHV1-18 gene), clone A, sub_clone IgG8.
FN562972 - Homo sapiens partial mRNA for immunoglobulin heavy chain variable region (IGHV1-18 gene), clone A, sub_clone IgG9.
FN562973 - Homo sapiens partial mRNA for immunoglobulin heavy chain variable region (IGHV1-18 gene), clone A, sub_clone IgG10.
FN562974 - Homo sapiens partial mRNA for immunoglobulin heavy chain variable region (IGHV1-18 gene), clone A, sub_clone IgG11.
FN562976 - Homo sapiens partial mRNA for immunoglobulin heavy chain variable region (IGHV1-18 gene), clone A, sub_clone IgG13.
FN562977 - Homo sapiens partial mRNA for immunoglobulin heavy chain variable region (IGHV1-18 gene), clone A, sub_clone IgG17.
FN562978 - Homo sapiens partial mRNA for immunoglobulin heavy chain variable region (IGHV1-18 gene), clone A, sub_clone IgG18.
FN562979 - Homo sapiens partial mRNA for immunoglobulin heavy chain variable region (IGHV1-18 gene), clone A, sub_clone IgG19.
FN562980 - Homo sapiens partial mRNA for immunoglobulin heavy chain variable region (IGHV1-18 gene), clone A, sub_clone IgG20.
FN562981 - Homo sapiens partial mRNA for immunoglobulin heavy chain variable region (IGHV1-18 gene), clone A, sub_clone IgG21.
FN562982 - Homo sapiens partial mRNA for immunoglobulin heavy chain variable region (IGHV1-18 gene), clone A, sub_clone IgG22.
FN562983 - Homo sapiens partial mRNA for immunoglobulin heavy chain variable region (IGHV1-18 gene), clone A, sub_clone IgG23.
FN564030 - Homo sapiens partial mRNA for immunoglobulin heavy chain variable region (IGHV1-18 gene), clone A, sub_clone IgG22.
AF485421 - Homo sapiens clone 023.102H immunoglobulin heavy chain variable region mRNA, partial cds.
HM774603 - Homo sapiens clone P10G227 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774885 - Homo sapiens clone P13G203 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774599 - Homo sapiens clone P10G223 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774606 - Homo sapiens clone P10G230 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774111 - Homo sapiens clone P04G205 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM773993 - Homo sapiens clone P02G209 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774454 - Homo sapiens clone P09G213 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774805 - Homo sapiens clone P12G216 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774184 - Homo sapiens clone P05G217 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774807 - Homo sapiens clone P12G219 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774884 - Homo sapiens clone P13G202 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774902 - Homo sapiens clone P13G221 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774908 - Homo sapiens clone P13G229 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774914 - Homo sapiens clone P13G235 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774917 - Homo sapiens clone P13G238 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM775020 - Homo sapiens clone P14G221 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM775023 - Homo sapiens clone P14G224 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774400 - Homo sapiens clone P08G235 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774451 - Homo sapiens clone P09G210 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774458 - Homo sapiens clone P09G217 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774802 - Homo sapiens clone P12G213 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774806 - Homo sapiens clone P12G217 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM775008 - Homo sapiens clone P14G209 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM775009 - Homo sapiens clone P14G210 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM775022 - Homo sapiens clone P14G223 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774453 - Homo sapiens clone P09G212 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774604 - Homo sapiens clone P10G228 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774809 - Homo sapiens clone P12G221 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM775011 - Homo sapiens clone P14G212 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM773987 - Homo sapiens clone P02G203_1d immunoglubulin gamma 2 heavy chain variable region-like mRNA, partial sequence.
HM774912 - Homo sapiens clone P13G233 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774594 - Homo sapiens clone P10G217 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774922 - Homo sapiens clone P13G243 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM773994 - Homo sapiens clone P02G210_1i immunoglubulin gamma 2 heavy chain variable region-like mRNA, partial sequence.
HM774369 - Homo sapiens clone P08G204_6d immunoglobulin gamma 2 heavy chain variable region-like mRNA, partial sequence.
HM774906 - Homo sapiens clone P13G227 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774045 - Homo sapiens clone P03G205 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774297 - Homo sapiens clone P07G202 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774301 - Homo sapiens clone P07G208 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774372 - Homo sapiens clone P08G207 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774385 - Homo sapiens clone P08G220 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774459 - Homo sapiens clone P09G218 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774460 - Homo sapiens clone P09G220_1d immunoglubulin gamma 2 heavy chain variable region-like mRNA, partial sequence.
HM774582 - Homo sapiens clone P10G204 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774890 - Homo sapiens clone P13G209 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM775010 - Homo sapiens clone P14G211 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774585 - Homo sapiens clone P10G207 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774174 - Homo sapiens clone P05G205 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774398 - Homo sapiens clone P08G233 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774443 - Homo sapiens clone P09G202 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774465 - Homo sapiens clone P09G225 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774792 - Homo sapiens clone P12G201 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774794 - Homo sapiens clone P12G203 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774813 - Homo sapiens clone P12G225 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774913 - Homo sapiens clone P13G234 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774595 - Homo sapiens clone P10G219 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM774705 - Homo sapiens clone P11G203 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM775028 - Homo sapiens clone P14G229 immunoglobulin gamma 2 heavy chain variable region mRNA, partial cds.
HM995562 - Homo sapiens isolate P2_Inf_2.3.1 immunoglobulin variable region mRNA, partial cds.
HM995933 - Homo sapiens isolate P3_Inf_6.3.7 immunoglobulin variable region mRNA, partial cds.
HM996279 - Homo sapiens isolate P5_nB93_HC immunoglobulin variable region mRNA, partial cds.
HM995376 - Homo sapiens isolate P2_Ass_1.8.6 immunoglobulin variable region mRNA, partial cds.
HM995814 - Homo sapiens isolate P3_Ass_5.1.1 immunoglobulin variable region mRNA, partial cds.
HM995819 - Homo sapiens isolate P3_Ass_5.1.7 immunoglobulin variable region-like mRNA, partial sequence.
HM996194 - Homo sapiens isolate P5_mB89_HC immunoglobulin variable region mRNA, partial cds.
HM995657 - Homo sapiens isolate P3_Agg_5.2.3 immunoglobulin variable region mRNA, partial cds.
HM996282 - Homo sapiens isolate P6_PC010_HC immunoglobulin variable region mRNA, partial cds.
HM995043 - Homo sapiens isolate P2_Agg_4.6.3 immunoglobulin variable region mRNA, partial cds.
HM995367 - Homo sapiens isolate P2_Ass_1.7.8 immunoglobulin variable region-like mRNA, partial sequence.
HM995385 - Homo sapiens isolate P2_Ass_1.8.15 immunoglobulin variable region-like mRNA, partial sequence.
HM995430 - Homo sapiens isolate P2_Ass_2.2.5 immunoglobulin variable region mRNA, partial cds.
HM995361 - Homo sapiens isolate P2_Ass_1.7.2 immunoglobulin variable region mRNA, partial cds.
HM995686 - Homo sapiens isolate P3_Ass_1.2.1 immunoglobulin variable region mRNA, partial cds.
HM995688 - Homo sapiens isolate P3_Ass_1.2.3 immunoglobulin variable region mRNA, partial cds.
HM995691 - Homo sapiens isolate P3_Ass_1.2.6 immunoglobulin variable region mRNA, partial cds.
HM995692 - Homo sapiens isolate P3_Ass_1.2.7 immunoglobulin variable region mRNA, partial cds.
HM995642 - Homo sapiens isolate P3_Agg_4.2.2 immunoglobulin variable region mRNA, partial cds.
HM995031 - Homo sapiens isolate P2_Agg_4.1.8 immunoglobulin variable region mRNA, partial cds.
HM996466 - Homo sapiens isolate P7_mB10_HC immunoglobulin variable region mRNA, partial cds.
HM995084 - Homo sapiens isolate P2_Agg_5.4.3 immunoglobulin variable region mRNA, partial cds.
HM995085 - Homo sapiens isolate P2_Agg_5.4.4 immunoglobulin variable region mRNA, partial cds.
HM995086 - Homo sapiens isolate P2_Agg_5.4.5 immunoglobulin variable region mRNA, partial cds.
HM995089 - Homo sapiens isolate P2_Agg_5.4.9 immunoglobulin variable region mRNA, partial cds.
HM995091 - Homo sapiens isolate P2_Agg_5.4.11 immunoglobulin variable region mRNA, partial cds.
HM995103 - Homo sapiens isolate P2_Agg_5.6.7 immunoglobulin variable region mRNA, partial cds.
HM995105 - Homo sapiens isolate P2_Agg_5.6.11 immunoglobulin variable region mRNA, partial cds.
HM996173 - Homo sapiens isolate P5_mB66_HC immunoglobulin variable region mRNA, partial cds.
HM995590 - Homo sapiens isolate P2_Inf_2.6.5 immunoglobulin variable region mRNA, partial cds.
HM995029 - Homo sapiens isolate P2_Agg_4.1.6 immunoglobulin variable region mRNA, partial cds.
HM995032 - Homo sapiens isolate P2_Agg_4.1.9 immunoglobulin variable region mRNA, partial cds.
HM995077 - Homo sapiens isolate P2_Agg_5.3.7 immunoglobulin variable region mRNA, partial cds.
HM995079 - Homo sapiens isolate P2_Agg_5.3.9 immunoglobulin variable region mRNA, partial cds.
HM995343 - Homo sapiens isolate P2_Ass_1.3.7 immunoglobulin variable region mRNA, partial cds.
HM995745 - Homo sapiens isolate P3_Ass_3.3.8 immunoglobulin variable region mRNA, partial cds.
HM995371 - Homo sapiens isolate P2_Ass_1.7.13 immunoglobulin variable region mRNA, partial cds.
HM995717 - Homo sapiens isolate P3_Ass_1.7.4 immunoglobulin variable region mRNA, partial cds.
HM995865 - Homo sapiens isolate P3_Inf_2.2.3 immunoglobulin variable region mRNA, partial cds.
HM996190 - Homo sapiens isolate P5_mB84_HC immunoglobulin variable region mRNA, partial cds.
HM995072 - Homo sapiens isolate P2_Agg_5.2.10 immunoglobulin variable region mRNA, partial cds.
HM995073 - Homo sapiens isolate P2_Agg_5.2.11 immunoglobulin variable region mRNA, partial cds.
HM774761 - Homo sapiens clone P12G121 immunoglobulin gamma 1 heavy chain variable region mRNA, partial cds.
AF165102 - Homo sapiens clone 23F.2 immunoglobulin heavy chain variable region DP-35 mRNA, partial cds.
HM774434 - Homo sapiens clone P09G122 immunoglobulin gamma 1 heavy chain variable region mRNA, partial cds.
HM995770 - Homo sapiens isolate P3_Ass_3.5.2 immunoglobulin variable region mRNA, partial cds.
HM995988 - Homo sapiens isolate P4_PC46_HC immunoglobulin variable region mRNA, partial cds.
HM995989 - Homo sapiens isolate P4_PC47_HC immunoglobulin variable region mRNA, partial cds.
HM995993 - Homo sapiens isolate P4_PC49_HC immunoglobulin variable region mRNA, partial cds.
HM994971 - Homo sapiens isolate P1_Agg_6.2.3 immunoglobulin variable region mRNA, partial cds.
HM994973 - Homo sapiens isolate P1_Agg_6.2.5 immunoglobulin variable region mRNA, partial cds.
HM994974 - Homo sapiens isolate P1_Agg_6.2.6 immunoglobulin variable region mRNA, partial cds.
HM995005 - Homo sapiens isolate P1_Agg_6.7.2 immunoglobulin variable region mRNA, partial cds.
HM995007 - Homo sapiens isolate P1_Agg_6.7.4 immunoglobulin variable region mRNA, partial cds.
HM995453 - Homo sapiens isolate P2_Ass_2.5.8 immunoglobulin variable region mRNA, partial cds.
HM995840 - Homo sapiens isolate P3_Inf_1.3.7 immunoglobulin variable region mRNA, partial cds.
HM995689 - Homo sapiens isolate P3_Ass_1.2.4 immunoglobulin variable region mRNA, partial cds.
HM995014 - Homo sapiens isolate P1_Agg_6.8.4 immunoglobulin variable region mRNA, partial cds.
HM995392 - Homo sapiens isolate P2_Ass_1.9.4 immunoglobulin variable region mRNA, partial cds.
HM995832 - Homo sapiens isolate P3_Ass_5.3.15 immunoglobulin variable region mRNA, partial cds.
HM994988 - Homo sapiens isolate P1_Agg_6.4.6 immunoglobulin variable region mRNA, partial cds.
HM995261 - Homo sapiens isolate P2_Agg_2.6.2 immunoglobulin variable region mRNA, partial cds.
HM995262 - Homo sapiens isolate P2_Agg_2.6.3 immunoglobulin variable region mRNA, partial cds.
HM995263 - Homo sapiens isolate P2_Agg_2.6.4 immunoglobulin variable region mRNA, partial cds.
HM995264 - Homo sapiens isolate P2_Agg_2.6.5 immunoglobulin variable region mRNA, partial cds.
HM995390 - Homo sapiens isolate P2_Ass_1.9.1 immunoglobulin variable region mRNA, partial cds.
HM995436 - Homo sapiens isolate P2_Ass_2.3.3 immunoglobulin variable region mRNA, partial cds.
HM995030 - Homo sapiens isolate P2_Agg_4.1.7 immunoglobulin variable region mRNA, partial cds.
HM995337 - Homo sapiens isolate P2_Ass_1.3.1 immunoglobulin variable region mRNA, partial cds.
HM995394 - Homo sapiens isolate P2_Ass_1.9.7 immunoglobulin variable region mRNA, partial cds.
HM995816 - Homo sapiens isolate P3_Ass_5.1.3 immunoglobulin variable region mRNA, partial cds.
HM995867 - Homo sapiens isolate P3_Inf_2.2.6 immunoglobulin variable region mRNA, partial cds.
HM995321 - Homo sapiens isolate P2_Ass_1.1.7 immunoglobulin variable region mRNA, partial cds.
AJ222554 - Homo sapiens mRNA for IgG, clone GA4.
MN178250 - Homo sapiens clone H1244 immunoglobulin heavy chain variable region mRNA, partial cds.
MK417336 - Homo sapiens clone KD102G1 immunoglobulin heavy chain variable region mRNA, partial cds.
MK416309 - Homo sapiens clone KD11H4 immunoglobulin heavy chain variable region mRNA, partial cds.
BC040042 - Homo sapiens cDNA clone IMAGE:5207605, partial cds.
HQ829365 - Homo sapiens immunoglobulin gamma heavy chain-like mRNA, complete sequence.
AJ294731 - Homo sapiens partial mRNA for immunoglobulin heavy chain constant region gamma 2 (IGHG2 gene).
JD022093 - Sequence 3117 from Patent EP1572962.
JD033333 - Sequence 14357 from Patent EP1572962.
AY180384 - Homo sapiens immunoglobulin heavy chain variable and constant region mRNA, partial cds.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P01859 (Reactome details) participates in the following event(s):

R-HSA-1861621 Cross-linking of FCGRIIA with IgG-coated Ag
R-HSA-2029455 Cross-linking of FCGRIA with IgG-coated Ag
R-HSA-2029457 Cross-linking of FCGRIIIA with IgG-coated Ag
R-HSA-8852481 Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates
R-HSA-173626 Activation of C1r
R-HSA-8852266 C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s
R-HSA-173631 Activation of C1s
R-HSA-2029452 Recruitment of SYK to phosphorylated ITAMs
R-HSA-9021306 C1-Inh binds and inactivates C1r, C1s
R-HSA-2029449 Phosphorylation of SYK by Src kinases
R-HSA-2029270 Recruitment of PLCgamma to membrane
R-HSA-2029273 PI3K binds to p-6Y-SYK
R-HSA-2029458 Recruitment of VAV1 to p-6Y-SYK
R-HSA-2197697 Recruitment of CRKII:DOCK180:ELMO complex to FCGR
R-HSA-2029272 Release of PLCG from FCGR
R-HSA-166753 Conversion of C4 into C4a and C4b
R-HSA-166792 Conversion of C2 into C2a and C2b
R-HSA-2029453 Phosphorylation of VAV
R-HSA-2029268 Phosphorylation and activation of PLCG
R-HSA-2029467 Activation of RAC1 by CRKII:DOCK180:ELMO
R-HSA-2029451 Activation of RAC1 by VAV
R-HSA-2029271 PI3K phosphorylates PIP2 to PIP3
R-HSA-2029481 FCGR activation
R-HSA-977606 Regulation of Complement cascade
R-HSA-173623 Classical antibody-mediated complement activation
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
R-HSA-166658 Complement cascade
R-HSA-166786 Creation of C4 and C2 activators
R-HSA-2029485 Role of phospholipids in phagocytosis
R-HSA-168249 Innate Immune System
R-HSA-166663 Initial triggering of complement
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: A0A286YEY4, A6NE66, AK128421, IGHG2 , IGHG2_HUMAN, P01859, uc328gxz.1
UCSC ID: ENST00000641095.1_10
RefSeq Accession: NM_000014.6
Protein: P01859 (aka IGHG2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.