Human Gene IFNA4 (ENST00000421715.3_7) from GENCODE V47lift37

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Description: interferon alpha 4 (from RefSeq NM_021068.4)
Gencode Transcript: ENST00000421715.3_7
Gencode Gene: ENSG00000236637.5_8
Transcript (Including UTRs)
Position: hg19 chr9:21,186,617-21,187,586 Size: 970 Total Exon Count: 1 Strand: -
Coding Region
Position: hg19 chr9:21,186,961-21,187,530 Size: 570 Coding Exon Count: 1

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr9:21,186,617-21,187,586)			mRNA (may differ from genome)		Protein (189 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
Malacards	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: IFNA4_HUMAN DESCRIPTION: RecName: Full=Interferon alpha-4; Short=IFN-alpha-4; AltName: Full=Interferon alpha-4B; AltName: Full=Interferon alpha-76; AltName: Full=Interferon alpha-M1; Flags: Precursor; FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. SUBCELLULAR LOCATION: Secreted. POLYMORPHISM: Two forms exist; alpha-4a (shown here) and alpha-4b. They seem to be equally abundant. SIMILARITY: Belongs to the alpha/beta interferon family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
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Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: IFNA4 Diseases sorted by gene-association score: rabies (7)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C009505 4,4'-diaminodiphenylmethane D008070 Lipopolysaccharides D008770 Methylnitrosourea D010126 Ozone D010269 Paraquat D011794 Quercetin D014260 Triclosan C018021 cobaltous chloride C028007 nickel monoxide

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 0.00 RPKM in (null) Total median expression: 0.00 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-7.70	56	-0.138	Picture	PostScript	Text
3' UTR	-58.30	344	-0.169	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR009079 - 4_helix_cytokine-like_core
IPR012351 - 4_helix_cytokine_core
IPR015589 - Interferon_alpha
IPR000471 - Interferon_alpha/beta/delta

Pfam Domains:
PF00143 - Interferon alpha/beta domain

SCOP Domains:
47266 - 4-helical cytokines

ModBase Predicted Comparative 3D Structure on P05014


Front	Top	Side

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Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0005132 type I interferon receptor binding GO:0005515 protein binding Biological Process: GO:0002250 adaptive immune response GO:0002286 T cell activation involved in immune response GO:0002323 natural killer cell activation involved in immune response GO:0006952 defense response GO:0006959 humoral immune response GO:0007596 blood coagulation GO:0009615 response to virus GO:0010469 regulation of receptor activity GO:0019221 cytokine-mediated signaling pathway GO:0030183 B cell differentiation GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0042100 B cell proliferation GO:0043330 response to exogenous dsRNA GO:0045087 innate immune response GO:0051607 defense response to virus GO:0060337 type I interferon signaling pathway Cellular Component: GO:0005576 extracellular region GO:0005615 extracellular space

Descriptions from all associated GenBank mRNAs


	KJ891429 - Synthetic construct Homo sapiens clone ccsbBroadEn_00823 IFNA4 gene, encodes complete protein. A02076 - H.sapiens mRNA for interferon-alpha. M27318 - Human interferon (IFN-alpha-M1) mRNA, complete cds. JD323574 - Sequence 304598 from Patent EP1572962. JD136735 - Sequence 117759 from Patent EP1572962. BC113640 - Homo sapiens interferon, alpha 4, mRNA (cDNA clone MGC:142200 IMAGE:8322692), complete cds. BC113642 - Homo sapiens interferon, alpha 4, mRNA (cDNA clone MGC:142202 IMAGE:8322694), complete cds. BC074965 - Homo sapiens interferon, alpha 4, mRNA (cDNA clone MGC:104059 IMAGE:30915507), complete cds. BC074966 - Homo sapiens interferon, alpha 4, mRNA (cDNA clone MGC:103901 IMAGE:30915288), complete cds. HQ258102 - Synthetic construct Homo sapiens clone IMAGE:100072411 interferon, alpha 4 (IFNA4) gene, encodes complete protein. HQ258746 - Synthetic construct Homo sapiens clone IMAGE:100072776 interferon, alpha 4 (IFNA4) gene, encodes complete protein. KJ905791 - Synthetic construct Homo sapiens clone ccsbBroadEn_15461 IFNA4 gene, encodes complete protein. AB590745 - Synthetic construct DNA, clone: pFN21AE2100, Homo sapiens IFNA4 gene for interferon, alpha 4, without stop codon, in Flexi system. JD251961 - Sequence 232985 from Patent EP1572962. JD085789 - Sequence 66813 from Patent EP1572962. JD052345 - Sequence 33369 from Patent EP1572962. JD268800 - Sequence 249824 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein P05014 (Reactome details) participates in the following event(s): R-HSA-909720 IFN alpha/beta binds to IFNAR2 R-HSA-909732 Phosphorylation of STAT2 R-HSA-909719 Recruitment of STAT2 to p-IFNAR1 R-HSA-909726 Phosphorylation of STAT1 R-HSA-909722 Release of p-STAT2:p-STAT1 dimer R-HSA-997309 Dephosphorylation of STAT1 by SHP2 R-HSA-909724 Recruitment of IFNAR1 R-HSA-909730 Phosphorylation of INFAR1 by TYK2 R-HSA-997311 Dephosphorylation of TYK2 by PTP1B R-HSA-909729 Activation of JAK kinases R-HSA-912680 Inhibition of JAK kinase activity by SOCS1/3 R-HSA-997314 Dephosphorylation of JAK1 by SHP1 R-HSA-909718 Formation of p-STAT1 homodimer R-HSA-909733 Interferon alpha/beta signaling R-HSA-933541 TRAF6 mediated IRF7 activation R-HSA-983231 Factors involved in megakaryocyte development and platelet production R-HSA-912694 Regulation of IFNA signaling R-HSA-913531 Interferon Signaling R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-109582 Hemostasis R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-168249 Innate Immune System R-HSA-168256 Immune System

Other Names for This Gene


	Alternate Gene Symbols: ENST00000421715.1, ENST00000421715.2, IFNA4_HUMAN, NM_021068, P05014, P13358, Q14CS4, Q5VV15, uc319rcy.1, uc319rcy.2 UCSC ID: ENST00000421715.3_7 RefSeq Accession: NM_021068.4 Protein: P05014 (aka IFNA4_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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