Human Gene IFIT5 (ENST00000371795.5_4) from GENCODE V47lift37
  Description: interferon induced protein with tetratricopeptide repeats 5 (from RefSeq NM_012420.3)
Gencode Transcript: ENST00000371795.5_4
Gencode Gene: ENSG00000152778.10_13
Transcript (Including UTRs)
   Position: hg19 chr10:91,174,325-91,180,754 Size: 6,430 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr10:91,174,556-91,178,405 Size: 3,850 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:91,174,325-91,180,754)mRNA (may differ from genome)Protein (482 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
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MGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: IFIT5_HUMAN
DESCRIPTION: RecName: Full=Interferon-induced protein with tetratricopeptide repeats 5; Short=IFIT-5; AltName: Full=Interferon-induced 58 kDa protein; AltName: Full=Retinoic acid- and interferon-inducible 58 kDa protein; Short=P58;
FUNCTION: IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication (By similarity).
INDUCTION: By interferons.
SIMILARITY: Belongs to the IFIT family.
SIMILARITY: Contains 8 TPR repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.36 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 238.59 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -103.70231-0.449 Picture PostScript Text
3' UTR -490.202349-0.209 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024125 - Interferon_induced_IFIT5
IPR001440 - TPR-1
IPR013026 - TPR-contain_dom
IPR011990 - TPR-like_helical
IPR013105 - TPR_2
IPR019734 - TPR_repeat

Pfam Domains:
PF07719 - Tetratricopeptide repeat
PF13176 - Tetratricopeptide repeat
PF13181 - Tetratricopeptide repeat
PF13374 - Tetratricopeptide repeat
PF13424 - Tetratricopeptide repeat

SCOP Domains:
81901 - HCP-like
48439 - Protein prenylyltransferase
48452 - TPR-like

ModBase Predicted Comparative 3D Structure on Q13325
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000049 tRNA binding
GO:0000339 RNA cap binding
GO:0003690 double-stranded DNA binding
GO:0003723 RNA binding
GO:0003727 single-stranded RNA binding
GO:0005515 protein binding
GO:0008266 poly(U) RNA binding

Biological Process:
GO:0002376 immune system process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response
GO:0051607 defense response to virus

Cellular Component:
GO:0005886 plasma membrane
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0032587 ruffle membrane
GO:0042995 cell projection
GO:0043231 intracellular membrane-bounded organelle
GO:0045177 apical part of cell
GO:0008385 IkappaB kinase complex


-  Descriptions from all associated GenBank mRNAs
  LP895792 - Sequence 656 from Patent EP3253886.
BC025786 - Homo sapiens interferon-induced protein with tetratricopeptide repeats 5, mRNA (cDNA clone MGC:34385 IMAGE:5229306), complete cds.
U34605 - Human retinoic acid- and interferon-inducible 58K protein RI58 mRNA, complete cds.
AK312358 - Homo sapiens cDNA, FLJ92678, highly similar to Homo sapiens interferon-induced protein with tetratricopeptide repeats 5 (IFIT5), mRNA.
AK293346 - Homo sapiens cDNA FLJ53857 complete cds, highly similar to Interferon-induced protein with tetratricopeptide repeats 5.
CU693072 - Synthetic construct Homo sapiens gateway clone IMAGE:100017352 5' read IFIT5 mRNA.
KJ898541 - Synthetic construct Homo sapiens clone ccsbBroadEn_07935 IFIT5 gene, encodes complete protein.
CR457031 - Homo sapiens full open reading frame cDNA clone RZPDo834A0218D for gene IFIT5, interferon-induced protein with tetratricopeptide repeats 5; complete cds, incl. stopcodon.
JD348021 - Sequence 329045 from Patent EP1572962.
JD501926 - Sequence 482950 from Patent EP1572962.
JD356743 - Sequence 337767 from Patent EP1572962.
JD490181 - Sequence 471205 from Patent EP1572962.
JD526820 - Sequence 507844 from Patent EP1572962.
JD159547 - Sequence 140571 from Patent EP1572962.
JD410975 - Sequence 391999 from Patent EP1572962.
JD318696 - Sequence 299720 from Patent EP1572962.
JD454193 - Sequence 435217 from Patent EP1572962.
JD352324 - Sequence 333348 from Patent EP1572962.
JD184810 - Sequence 165834 from Patent EP1572962.
JD551369 - Sequence 532393 from Patent EP1572962.
JD477611 - Sequence 458635 from Patent EP1572962.
JD178746 - Sequence 159770 from Patent EP1572962.
JD468339 - Sequence 449363 from Patent EP1572962.
JD236100 - Sequence 217124 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2R5X9, B4DDV1, ENST00000371795.1, ENST00000371795.2, ENST00000371795.3, ENST00000371795.4, IFIT5_HUMAN, ISG58, NM_012420, Q13325, Q5T7I9, Q6IAX3, RI58, uc318jkh.1, uc318jkh.2
UCSC ID: ENST00000371795.5_4
RefSeq Accession: NM_012420.3
Protein: Q13325 (aka IFIT5_HUMAN or IFT5_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.